Frailty syndrome: an overview

Chen, Xujiao; Mao, Genxiang; Leng, Sean X.

doi:10.2147/cia.s45300

Cited by 515 publications

(447 citation statements)

References 93 publications

Supporting

Mentioning

420

Contrasting

Unclassified

Order By: Relevance

“…Our observation of positive associations of CRP with risk of frailty is consistent with previous observations from both cross-sectional and longitudinal studies [10,31,32,33] and supports the suggestion that chronic inflammation may be one of the key pathways leading to frailty [34]. As illustrated in our analyses and elsewhere [31,35], inflammation may often go along with increased OS.…”

Section: Discussionsupporting

confidence: 92%

Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

et al. 2015

View full text Add to dashboard Cite

Background: Oxidative stress (OS) and inflammatory biomarkers have been postulated to be important factors in the development of age-related diseases. While causes of frailty are complex and multidimensional based on the interaction of genetic, biological, physical, and environmental factors, the biological basis of frailty has been difficult to establish. Objective: In this study, we aimed to assess the possible association between different OS and inflammatory biomarkers and frailty. Methods: This cross-sectional analysis was performed among 2,518 subjects participating in a large population-based cohort study on aging conducted in Germany. Frailty was assessed as proposed by Fried et al. [J Gerontol A Biol Sci Med Sci 2001;56:M146-M156]. OS biomarkers, biological antioxidant potential (BAP), derivate of reactive oxygen metabolites (d-ROM) and total thiol levels (TTL), and an established biomarker of inflammation C-reactive protein (CRP) were measured by spectrophotometry and immunoturbidimetry. Logistic regression models were performed to assess the relationship between the OS biomarkers and frailty status. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to quantify the associations. Results: Mean levels of d-ROM, TTL, and CRP differed between frail and non-frail participants (p values <0.0001). Comparing highest and lowest quartiles of the biomarkers, statistically significant positive associations with frailty were observed for d-ROM (OR: 2.02, 95% CI: 1.25-3.25) and CRP (OR: 3.15, 95% CI: 2.00-4.96), respectively, after controlling for age and sex. An inverse statistically significant association with frailty was observed for TTL (OR: 0.42, 95% CI: 0.25-0.69). Conclusion: The strong associations with OS biomarkers and CRP support a major role of OS and inflammation in the development of frailty, which should be followed up in further longitudinal studies on frailty.

show abstract

Section: Discussionsupporting

confidence: 92%

Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…cia (Chen et al, 2014). Nesta trajetória existe maior potencial de reversibilidade em situações de pré-fragilidade, sendo que a síndrome atinge um ponto de difícil retorno após a instalação da incapacidade/ dependência (Strandberg et al, 2011).…”

Section: Enquadramentounclassified

Frailty and associated risk factors in independent older people living in rural areas

Preto

Conceição

Amaral³

et al. 2018

Rev. Enf. Ref.

View full text Add to dashboard Cite

Fragilidade e fatores de risco associados em pessoas idosas independentes residentes em meio ruralFrailty and associated risk factors in independent older people living in rural areas Fragilidad y factores de riesgo asociados en personas ancianas independientes residentes en el medio rural AbstractBackground: The diagnosis of the frailty syndrome is essential in the planning of elderly health interventions. Objective: To assess the prevalence of frailty among older people living in rural communities and its associated factors. Methodology: A cross-sectional study was conducted with 435 elderly subjects who were classified according to the frailty phenotype. The following instruments were also applied: Short Portable Mental Status Questionnaire (SPMSQ), Charlson Comorbidity Index (CCI), Barthel Index (BI), and Lawton And Brody Instrumental Activities Of Daily Living (IADL) Scale. Association tests, mean comparison tests, and correlation analysis (p < 0.05) were used. Results: The sample (74.3 ± 7.1 years) was predominantly female (62.3%) and showed prevalence rates of 33.3% for non-frailty, 46.2% for pre-frailty, and 20.5% for frailty. Frailty was associated with self-perceived health, pain intensity, use of walking aids, and sensory problems. Frail older people were more dependent on activities of daily living. Conclusion: Stronger correlations were found between frailty and the CCI and ELB scores, age, and number of medications per day, in this order.

show abstract

“…46 Although no multi-centre studies exist that demonstrate differences in care for frail patients, the group certainly deserves more attention. As these patients are at a higher risk of complications following invasive procedures and of adverse effects from medication, they should be managed with extra caution.…”

Section: Care For Frail Patientsmentioning

confidence: 99%

Hypertension and Frailty Syndrome in Old Age: Current Perspectives

Uchmanowicz

Chudiak

Jankowska‐Polańska

et al. 2017

Cardiac Failure Review

View full text Add to dashboard Cite

Hypertension is considered the most common disorder in the general population. It is both a health and a financial problem worldwide.The Writing Group of the American Society of Hypertension defines hypertension as a cardiovascular syndrome resulting from a number of interconnected factors. 1 Therefore, a comprehensive evaluation is required, involving both the cardiovascular system and other risk factors. In the global population, the prevalence of hypertension is 26.4 %, which is expected to increase to one-third of the population by 2025. 2 The elderly comprise a special group of hypertensive patients because of ageing-related processes. In accordance with data from the Framingham study, 58.9 % of people aged ≥65 and 70 % of those aged ≥80 years are hypertensive. 3 Most patients in the group have isolated systolic hypertension, with normal diastolic blood pressure (DBP) valuesbelow 90 mmHg. In the elderly population, systolic blood pressure (SBP) is a more significant risk factor for cardiovascular complications than DBP. Chronic high SBP leads to left ventricular hypertrophy, as decreased elasticity of large blood vessels -particularly the aortaputs extra strain on the heart. 4 The ageing process involves a number of changes contributing to the development of hypertension. Besides decreased blood vessel elasticity, these include increased collagen content in the extracellular matrix, decreased numbers of elastic fibres, increased vessel wall thickness, and decreased vessel lumen.In the elderly, the lower number of elastic fibres in the vessel wall contributes to increased SBP. AbstractHypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged ≥80 years. In the elderly population, isolated systolic hypertension is quite common. High systolic blood pressure is associated with an increased risk of cardiovascular disease, cerebrovascular disease, peripheral artery disease, cognitive impairment and kidney disease. Considering the physiological changes resulting from ageing alongside multiple comorbidities, treatment of hypertension in elderly patients poses a significant challenge to treatment teams. Progressive disability with regard to the activities of daily life, more frequent hospitalisations and low quality of life are often seen in elderly patients. There is discussion in the literature regarding frailty syndrome associated with old age. Frailty is understood to involve decreased resistance to stressors, depleted adaptive and physiological reserves of a number of organs, endocrine dysregulation and immune dysfunction. The primary dilemma concerning frailty is whether it should only be defined on the basis of physical factors, or whether psychological and social factors should also be included. Proper nutrition and motor rehabilitation should be prioritised in care for frail pa...

show abstract

Frailty syndrome: an overview

Cited by 515 publications

References 93 publications

Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

Frailty and associated risk factors in independent older people living in rural areas

Hypertension and Frailty Syndrome in Old Age: Current Perspectives

Contact Info

Product

Resources

About