Advances in the Preclinical Study of Ischemic Stroke 2012
DOI: 10.5772/32367
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Frameless Stereotaxy in Sheep - Neurosurgical and Imaging Techniques for Translational Stroke Research

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Cited by 6 publications
(6 citation statements)
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“…First, it is useful to allocate coordinates of distinct anatomical structures to experimental findings, for example for electrophysiological (Gierthmuehlen et al, 2014 ) or functional MRI data. Second, it offers a more objective and highly standardized reference system for stereotaxic targeting of anatomical structures (Dreyer et al, 2012 ; Staudacher et al, 2014 ) due to the normalization of the created template. Third, the template provides the ground for subsequent creation of a highly precise ovine brain atlas based on a higher sample population.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…First, it is useful to allocate coordinates of distinct anatomical structures to experimental findings, for example for electrophysiological (Gierthmuehlen et al, 2014 ) or functional MRI data. Second, it offers a more objective and highly standardized reference system for stereotaxic targeting of anatomical structures (Dreyer et al, 2012 ; Staudacher et al, 2014 ) due to the normalization of the created template. Third, the template provides the ground for subsequent creation of a highly precise ovine brain atlas based on a higher sample population.…”
Section: Discussionmentioning
confidence: 99%
“…Of note, all MR imaging (MRI) data sets were obtained from studies conducted for different purposes (animal license numbers TVV33/09, TVV09/11, TVV33/12, and W04/19). For those studies, sheep were subjected to stereotactic surgery using a frameless stereotactic device (Rogue Research Ltd., Canada, Dreyer et al, 2012 ). The procedures required structural/anatomical MRI data sets for neuronavigation which were used for the herein presented study.…”
Section: Methodsmentioning
confidence: 99%
“…Experimental ruminants (sheep, goats) are predominantly used to simulate acute cerebrovascular pathologies such as ischaemic stroke [3234] and cerebral haemorrhage [35]. In domestic dogs, hypercaloric or unbalanced diet, lack of physical exercise and dyslipidemia are prevalent [36].…”
Section: Introductionmentioning
confidence: 99%
“…Baseline MR imaging (1.5T Phillips MRI, Gyroscan Intera; Philips, Koninklijke, The Netherlands) was performed prior to experimentation in each animal to prepare stereotaxic neurosurgery using a frameless device. 13 An array of three MR-sensitive fiducial markers defining individual positions of the scanned head were installed just prior to imaging. The arrays were adopted on an individualized tooth bar (Rogue Research Inc., Canada) and mounted to the individual maxillary dent profiles using hydroplastic (TAK Systems, US).…”
Section: Methodsmentioning
confidence: 99%