‘Frank’s sign: dermatological marker for coronary artery disease’

Elawad, Omer Ali Mohamed Ahmed; Albashir, Ahmed Abdalazim Dafallah

doi:10.1093/omcr/omab089

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…As DELC has been recommended as a marker for generalized atherosclerosis, researchers have looked at whether people with DELC have a shorter telomere, which is linked to faster cell turnover and early aging, which can lead to atherosclerosis [8]. DELC has also been proposed as a valuable dermatological indicator of accelerated aging, as seen by excessive telomere loss, as well as an indirect marker of high-risk metabolic syndrome patients [9].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Diagonal Earlobes Crease and Ischemic Stroke Risk

Temeecharoentaworn

Tiamkao

Ienghong

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Diagonal earlobe crease has been shown as the association between atherosclerotic disease. AIM: To examine the relationship between diagonal earlobes crease (DELC) and ischemic stroke. METHODS: This prospective study recruited 175 consecutive acute ischemic stroke patients admitted to the Stroke Unit of Srinagarind Hospital, Faculty of Medicine, Khon Kaen University between May 2021 and August 2021. Clinical data included age, gender, underlying disease, clinical presentation, vital signs, brain computed tomography and DELC assessed for both ears. The study was approved by the Human Ethics Research Committee of Khon Kaen University, Thailand. RESULTS: patients were assessed on clinical presentation and brain computed tomography (CT) findings. There were 31 patients with transient ischemic attacks (17.7% of the patients) and 144 patients with cerebral infarction (82.3%). In all participants were male 58.9% and 72 were female (41.1%). The top three clinical presentations were hemiparesis (29.6%), dysarthria (27.0%), and facial palsy (17.5%). One hundred and thirty-one patients (74.9%) had underlying diseases; hypertension (24.2%), diabetic mellitus (14.4%), atrial fibrillation (4.9%), chronic kidney disease (2.0%), dyslipidemia (8.0%), valvular heart disease (2.3%), coronary heart disease (2.6%), previous stroke (8.1%), and other diseases (8.4%). Only 44 patients (25.1%) had no underlying disease. Frank’s sign (DELC) was present in only 13 patients (7.4%). There were similar proportions of major underlying conditions, hypertension, and diabetic mellitus for both groups, and no differences apparent for gender or old age. On CT scans both DELC and non-DELC patients showed lacunar infarction as the major source of ischemic stroke. CONCLUSIONS: Due to our very small sample of DELC patients, we could draw no conclusions about the relationship between DELC and ischemic stroke and its predictive utility as a biomarker for ischemic stroke. Given the much higher proportions of DELC patients reported in international literature we raise the possibility of physiological, genetic, or ethnic differences in Thai, or Asian samples, for future research.

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Section: Introductionmentioning

confidence: 99%

Relationship between Diagonal Earlobes Crease and Ischemic Stroke Risk

Temeecharoentaworn

Tiamkao

Ienghong

et al. 2022

Open Access Maced J Med Sci

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Cardiodermatology: the heart of the connection between the skin and cardiovascular disease

Gelfand,

Song,

Langan

et al. 2024

Nat Rev Cardiol

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Earlobe Crusade as Useful Screening for Coronary Artery Disease in Low- and Middle-Income Countries of Asian; Bring the Ear-Heart Axis to the Spotlight in Cardiology: Systematic Review and Implications for Clinical Practice

Laksono¹,

Ramadhan

Salsabila

2023

Apollo Medicine

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Background: Asia has the highest cardiovascular disease mortality worldwide, with most of these deaths occurring in low-income developing countries (lower- and middle-income countries [LMIC]). When compounded with issues in LMICs, such as minimal health resources and inadequate access to health facilities, these challenges make early detection efforts utilizing sophisticated diagnostic tools challenging. Earlobe crusade (ELC), an atherosclerosis marker, is the solution. Objective: This research assessed the relationship between ELC and coronary artery disease (CAD) evidenced by coronary angiography (CAD-CAG-confirmed) in LMIC Asian populations. Methods: This study followed the Preferred Reporting Items for Systematic Review and Meta-Analysis approach to identify studies on the connection between ELC and CAD-CAG-confirmed in LMIC Asian populations. LMIC classification in Asia based on World Bank statistical data through 2021. This study searched MEDLINE, Embase, ProQuest, and Scopus using population, intervention, comparison, and outcome criteria. Then, the risk of bias and diagnostic value was evaluated. Results: This systematic review found six articles with 1657 participants. All studies showed a significant relationship between the presence of ELC and CAD. ELC diagnostic values for CAD, sensitivity 74%–98%, and specificity 52.5%–91.49%. Several multivariate regression analysis studies showed that ELC was independently associated with CAD. Conclusion: The ELC examination is the best option for CAD screening in countries with limited resources and health facilities. ELC is straightforward, affordable, and valuable as a CAD diagnostic marker.

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‘Frank’s sign: dermatological marker for coronary artery disease’

Cited by 3 publications

References 2 publications

Relationship between Diagonal Earlobes Crease and Ischemic Stroke Risk

Relationship between Diagonal Earlobes Crease and Ischemic Stroke Risk

Cardiodermatology: the heart of the connection between the skin and cardiovascular disease

Earlobe Crusade as Useful Screening for Coronary Artery Disease in Low- and Middle-Income Countries of Asian; Bring the Ear-Heart Axis to the Spotlight in Cardiology: Systematic Review and Implications for Clinical Practice

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