Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux

He, Bin; Zhang, Wenkan; He, Jiaming

doi:10.3389/fphar.2021.653212

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Excessive autophagy has been well documented during ischemia/reperfusion injury, where it can lead to the destruction of essential molecules and organelles, so as to favor cell death [ 27 , 28 ]. Excessive autophagy has also been shown to induce cell death in tumor cells [ 29 ]. In this paper, excessive autophagy was associated with enhanced cytotoxicity of NCTD on BC cells in acidic culture.…”

Section: Discussionmentioning

confidence: 99%

Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture

et al. 2022

IJMS

View full text Add to dashboard Cite

The acidic tumor microenvironment stands as a major obstacle to the efficient elimination of tumor cells. Norcantharidin (NCTD) is a powerful antitumor agent with multiple bioactivities. However, the effect of NCTD under acidic conditions is still unclear. Here, we report that NCTD can efficiently kill bladder cancer (BC) cells in acidic culture, and more intriguingly, NCTD can induce immunogenic cell death (ICD), thereby promoting antitumor immunity. In NCTD-treated BC cells, the surface-exposed calreticulin (ecto-CALR) was significantly increased. Consistently, co-culture with these cells promoted dendritic cell (DC) maturation. The NCTD-induced ICD is autophagy dependent, as autophagy inhibition completely blocked the NCTD-induced ecto-CALR and DC maturation. In addition, the DC showed a distinct maturation phenotype (CD80high CD86low) in acidic culture, as compared to that in physiological pH (CD80 high CD86high). Finally, the NCTD-induced ICD was validated in a mouse model. NCTD treatment significantly increased the tumor-infiltrating T lymphocytes in MB49 bladder cancer mice. Immunizing mice with NCTD-treated MB49 cells significantly increased tumor-free survival as compared to control. These findings demonstrate that NCTD could induce ICD in an acidic environment and suggest the feasibility to combine NCTD with anticancer immunotherapy to treat BC.

show abstract

Section: Discussionmentioning

confidence: 99%

Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…This natural product has been shown to inhibit the growth as well as the migration of osteosarcoma cells HOS and MG63. Studies show that its anti-cancer activity stems from promoting excessive autophagy flux (He et al 2021). Fraxinellone ( 24) has also exhibited anticancer activity by inhibiting programmed cell death-ligand 1 (PD-L1) expression when it was assayed in in vivo studies (Xing et al 2018).…”

Section: Anticancer Activitymentioning

confidence: 99%

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

et al. 2023

View full text Add to dashboard Cite

Phytochemical studies on the roots, twigs and leaves of Meliaceae and Rutaceae family plants have revealed the presence of non-complex terpenes derived from limonoid fragmentation. The occurrence and chemical structure of these degraded limonoids isolated from 1930 to March 2022 are reported in this review. Particular attention is given to the degradation levels in these compounds and their absolute configuration to discover presumable deconstruction pathways from more complex limonoids. Plausible intermediates have been postulated for most of them that would explain their origin from limonoids. The total or semi-synthesis of the most isolated degraded limonoids or analogues remains undescribed. This review focuses on the bioactivity of these fragmented limonoids and their synthesized analogues. Based on pharmacological and agrochemical studies, degraded limonoids appear to be excellent structural leads to consider for the total or semi-synthesis of more potent derivatives with the aim of discovering new hits and clarifying their modes of action.

show abstract

Herbs and their Bioactive Compound’s Role in the Management of Rheumatoid Arthritis and Related Inflammatory Conditions

Bharati,

Singh,

Singh

et al. 2024

The Chemistry Inside Spices &Amp; Herbs: Research and Development

View full text Add to dashboard Cite

Arthritis is the medical term for swelling or inflammation of one or more joints, ligaments, and surrounding tissues. Rheumatoid arthritis (RA) is an inflammatory autoimmune arthritis that is one of the 100 forms of arthritis. Currently, this autoimmune inflammatory arthritis is incurable. Still, treatment is done on an individual basis of symptoms with the primary goal of minimising joint discomfort and inflammation, improving joint performance, and preventing cartilage damage and distortion. Pharmacotherapy of Rheumatoid arthritis includes nonsteroidal antiinflammatory drugs (paracetamol, naproxen sodium, ketoprofen, diclofenac), biological agents (rituximab, adalimumab, tocilizumab), and disease-modifying anti-rheumatic drugs (penicillamine, sulfasalazine, gold), immunosuppressants (methotrexate, cyclophosphamide), and corticosteroids (prednisolone and methylprednisolone) along with physical therapy. The inability to achieve complete remission from chronic diseases, as well as the expensive cost of new treatments, and the long-term side effects and risks of modern medicine, have all contributed to a rise in public interest in alternative medicine in recent years and different approaches to treating arthritis are continually being researched. Dietary changes, nutritional supplements, and the use of botanicals and phytochemicals are some of the more popular alternative treatment options for RA. Dietary phenolic compounds, terpenoids, saponins, flavonoids, carotenoids, and alkaloids have effectively slowed the progression of arthritic disease because of their ability to alter pro-oxidant and pro-inflammatory pathways. In addition to whole herbs and spices and their extract, many isolated phytoconstituents have been discovered to have healing capability in the treatment of rheumatoid arthritis. These compounds include aconite, brucine, kaempferol, tamaractam, andrographolide, artemisinin, asiaticoside A, bufalin, hecogenin, curcumin, swertiamarin, resveratrol, cardamonin celastrol, lapachol, brazilin, thymoquinone, asperosaponin VI, liquiritin, βelemene, oleanolic acid acetate, ellipticine, hesperidin, and sinomenime. The current review outlines the role of medicinal plants, herbs, dietary supplements, and isolated bioactive compounds from plants in the treatment and management of rheumatoid arthritis, as well as their mechanism of pharmacological action.

show abstract

Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux

Cited by 3 publications

References 36 publications

Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture

Norcantharidin Induces Immunogenic Cell Death of Bladder Cancer Cells through Promoting Autophagy in Acidic Culture

Degraded limonoids: biologically active limonoid fragments re-enhancing interest in Meliaceae and Rutaceae sources

Herbs and their Bioactive Compound’s Role in the Management of Rheumatoid Arthritis and Related Inflammatory Conditions

Contact Info

Product

Resources

About