Frecuencia de aparición y validez predictiva de la disfunción olfatoria y del gusto en pacientes con infección por SARS-CoV-2

Torres, Luis Ángel Pérula de; González-Lama, Jesús; García, Celia Jiménez; Montero, Rosa Sánchez; Garrido, Faustino Rider; López, Yolanda Ortega; Conde, Diego Pajares; Baena, Miguel Ramírez; Martínez, Ignacio Párraga; Romero‐Rodríguez, Esperanza

doi:10.1016/j.medcli.2020.12.015

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…A variety of Spanish studies (4,5), as well as some international studies (6, 7), addressed the clinical characteristics of the COVID-19 disease. Fever, dry cough, tiredness or fatigue, dyspnea, pharyngeal pain, chills, and diarrhea are the symptoms that appear most frequently in the acute phase of the disease, but the symptomatology can be prolonged over time, leading to persistent COVID-19.…”

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confidence: 99%

Hospital admission and vaccination as predictive factors of long COVID-19 symptoms

et al. 2022

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BackgroundSince the beginning of the COVID-19 pandemic, a great variability of symptoms that affect all organs and systems of the body has been identified in patients with SARS-CoV-2 infection; this symptomatology can sometimes persist over time, giving rise to the so-called long COVID or post-COVID. The aim of this study is to delve into the clinical characterization of these patients, as well as to take into account the influence of factors such as hospitalization, admission to ICU, history of pneumonia, or vaccination status on the persistence of symptoms.Material and methodsAn observational, descriptive, multicenter, and retrospective study was designed with a series of cases of people who presented long COVID, which includes univariate, bivariate, and multivariate analyses. Data were obtained from an online ad hoc questionnaire, and statistical analysis was performed using SPSS Software Version 25 (IBM-Inc., Chicago, IL, USA).ResultsHospitalization, ICU admission, history of pneumonia, and vaccination were predictive factors (positive or negative) for the following long-COVID symptoms: headache, menstrual disorders, joint pain, cough, chills, nasal congestion, back pain, abdominal pain, weight loss, eye discomfort, facial erythema, itching, tremors, dizziness, seizures, sleeping difficulty, dry eyes, palpitations, fatigue, paresthesia, dyspnea, aphonia, chest pain, high blood pressure, vomiting, memory loss, brain fog, hypothermia, low blood pressure, sputum or phlegm, lack of concentration, hair loss, and erectile dysfunction.ConclusionThis study provides evidence on the clinical characterization of patients suffering from long COVID in order to offer them the most appropriate treatments.

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Section: Introductionmentioning

confidence: 99%

Hospital admission and vaccination as predictive factors of long COVID-19 symptoms

et al. 2022

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Evaluación de la prueba diagnóstica de detección rápida de antígeno de covid-19 (Panbio Covid rapid test) en atención primaria

Rubio

Zamora

Aracil

et al. 2021

Medicina de Familia. SEMERGEN

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Objetivo: La infección por covid-19 requiere un diagnóstico temprano, siendo la PCR la prueba gold estándar. Los protocolos propugnan el uso de pruebas antigénicas rápidas que precisan de evaluación en la práctica clínica real. El objetivo fue evaluar la prueba diagnóstica de detección rápida de antígeno, Panbio Covid rapid test, comparada con la PCR, en los pacientes con clínica de 5 o menos días de evolución y con alta sospecha de infección por covid-19 en un centro de salud. Materiales y Métodos: 103 pacientes mayores de 14 años que acudieron a un centro de salud urbano ubicado en el Distrito de Usera de Madrid, con alta sospecha de infección por covid-19, en los primeros 5 días de evolución desde el inicio de los síntomas durante el mes de noviembre de 2020. Intervenciones: se realizan las pruebas diagnósticas de Covid-19: antígeno y PCR. Resultados: La prevalencia de la enfermedad fue del 24.3% según la prueba PCR y 17.5% según el test antigénico rápido. La sensibilidad fue de 72% (IC al 95%: 54.3-89.6%). La especificidad fue del 100%. Los valores predictivos positivo y negativo fueron del 100% y del 91.8% respectivamente. En el análisis bivariante, no hubo relación entre los síntomas y la presencia de enfermedad, excepto para las mialgias (p=0.030). En el análisis multivariado se encontró relación entre la tos, la disnea, la fiebre, las mialgias, la anosmia/ageusia y los síntomas oculares y la presencia de enfermedad. Conclusiones: la sensibilidad y la especificidad para el test de antígeno rápido Panbio son similares a otros estudios realizados en atención primaria. En prevalencia alta de enfermedad y con síntomas de alta sospecha, los resultados positivos del test se pueden considerar definitivos, pero los resultados negativos requerirán confirmación. Las mialgias, la fiebre, la disnea, la anosmia/ageusia y los síntomas oculares se pueden relacionar más con la presencia de covid-19.

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RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

et al. 2022

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Chemosensory scientists have been skeptical that reports of COVID-19 taste loss are genuine, in part because before COVID-19 taste loss was rare and often confused with smell loss. Therefore, to establish the predicted prevalence rate of taste loss in COVID-19 patients, we conducted a systematic review and meta-analysis of 376 papers published in 2020–2021, with 241 meeting all inclusion criteria. Drawing on previous studies and guided by early meta-analyses, we explored how methodological differences (direct vs. self-report measures) may affect these estimates. We hypothesized that direct measures of taste are at least as sensitive as those obtained by self-report and that the preponderance of evidence confirms taste loss is a symptom of COVID-19. The meta-analysis showed that, among 138,897 COVID-19-positive patients, 39.2% reported taste dysfunction (95% confidence interval: 35.34%–43.12%), and the prevalence estimates were slightly but not significantly higher from studies using direct (n = 18) versus self-report (n = 223) methodologies (Q = 0.57, df = 1, P = 0.45). Generally, males reported lower rates of taste loss than did females, and taste loss was highest among middle-aged adults. Thus, taste loss is likely a bona fide symptom of COVID-19, meriting further research into the most appropriate direct methods to measure it and its underlying mechanisms.

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Frecuencia de aparición y validez predictiva de la disfunción olfatoria y del gusto en pacientes con infección por SARS-CoV-2

Cited by 6 publications

References 28 publications

Hospital admission and vaccination as predictive factors of long COVID-19 symptoms

Hospital admission and vaccination as predictive factors of long COVID-19 symptoms

Evaluación de la prueba diagnóstica de detección rápida de antígeno de covid-19 (Panbio Covid rapid test) en atención primaria

RETRACTED AND REPLACED: Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis

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