Free and Zeolite-Immobilized Probiotic Mixture Versus Sodium Valproate in Prevention of Oxidative Stress and Modulation of the L-Arginine Intracellular Metabolic Pathways in  the Rat Brain and Blood Following Dexamphetamine-Induced Bipolar D

Alchujyan, N. Kh.; Hovhannisyan, Margarita; Movsesyan, N. H.; Madoyan, R.; Sargsyan, H. H.; Aghababova, A. A.; Minasyan, G. H.; Hairapetyan, H. L.; Kevorkian, R. G.; Chailyan, S. G.; Kevorkian, G. A.

doi:10.17628/ecb.2018.7.42-51

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…One study showed that probiotic treatment reduced the hippocampal oxidative stress (Chunchai et al, 2018). Five studies reported that probiotic supplementations attenuated oxidative enzymes (Sun et al, 2016;Alchujyan et al, 2018;Xu et al, 2018;Ramalho et al, 2019;Salami et al, 2019). Consistently, 4 studies showed that probiotic administration increases antioxidant activity (Divyashri et al, 2015;Huang et al, 2018;Ho et al, 2019;Roy Sarkar et al, 10.3389/fnins.2022.1065995 2020.…”

Section: Oxidant and Anti-oxidant Factorsmentioning

confidence: 92%

The microbiota-gut- hippocampus axis

Saifeddine

Soheili

2022

Front. Neurosci.

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IntroductionIt is well known that the intestinal bacteria substantially affect physiological processes in many body organs. Especially, through a bidirectional communication called as gut-microbiota-brain axis, the gut microbiota deeply influences development and function of the nervous system. Hippocampus, as a part of medial temporal lobe, is known to be involved in cognition, emotion, and anxiety. Growing evidence indicates that the hippocampus is a target of the gut microbiota. We used a broad search linking the hippocampus with the gut microbiota and probiotics.MethodsAll experimental studies and clinical trials published until end of 2021 were reviewed. Influence of the gut microbiota on the behavioral, electrophysiological, biochemical and histological aspects of the hippocampus were evaluated in this review.ResultsThe effect of disrupted gut microbiota and probiotic supplements on the microbiota-hippocampus link is also considered. Studies show that a healthy gut microbiota is necessary for normal hippocampus dependent learning and memory and synaptic plasticity. The known current mechanisms are production and modulation of neurotrophins, neurotransmitters and receptors, regulation of intracellular molecular processes, normalizing the inflammatory/anti-inflammatory and oxidative/antioxidant factors, and histological stability of the hippocampus. Activity of the hippocampal neuronal circuits as well as behavioral functions of the hippocampus positively respond to different mixtures of probiotic bacteria.DiscussionGrowing evidence from animal researches indicate a close association between the hippocampus with the gut microbiota and probiotic bacteria as well. However, human studies and clinical trials verifying such a link are scant. Since the most of papers on this topic have been published over the past 3 years, intensive future research awaits.

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Section: Oxidant and Anti-oxidant Factorsmentioning

confidence: 92%

The microbiota-gut- hippocampus axis

Saifeddine

Soheili

2022

Front. Neurosci.

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Targeting Underlying Inflammation in Carcinoma Is Essential for the Resolution of Depressiveness

Borovcanin

Vesić

Arsenijević

et al. 2023

Cells

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In modern clinical practice and research on behavioral changes in patients with oncological problems, there are several one-sided approaches to these problems. Strategies for early detection of behavioral changes are considered, but they must take into account the specifics of the localization and phase in the course and treatment of somatic oncological disease. Behavioral changes, in particular, may correlate with systemic proinflammatory changes. In the up-to-date literature, there are a lot of useful pointers on the relationship between carcinoma and inflammation and between depression and inflammation. This review is intended to provide an overview of these similar underlying inflammatory disturbances in both oncological disease and depression. The specificities of acute and chronic inflammation are considered as a basis for causal current and future therapies. Modern therapeutic oncology protocols may also cause transient behavioral changes, so assessment of the quality, quantity, and duration of behavioral symptoms is necessary to prescribe adequate therapy. Conversely, antidepressant properties could be used to ameliorate inflammation. We will attempt to provide some impetus and present some unconventional potential treatment targets related to inflammation. It is certain that only an integrative oncology approach is justifiable in modern patient treatment.

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Free and Zeolite-Immobilized Probiotic Mixture Versus Sodium Valproate in Prevention of Oxidative Stress and Modulation of the L-Arginine Intracellular Metabolic Pathways in the Rat Brain and Blood Following Dexamphetamine-Induced Bipolar D

Abstract: Institute of fine organic chemistry (FOC) of scientific technological center of organic and pharmaceutical chemistry NAS, Republic of Armenia EXPERIMENTAL Materials Depakine, containing sodium valproate (VPA) (Sanofi-Aventis U.S. LLC) as an active substance, d-amphetamine

Cited by 2 publications

References 45 publications

The microbiota-gut- hippocampus axis

The microbiota-gut- hippocampus axis

Targeting Underlying Inflammation in Carcinoma Is Essential for the Resolution of Depressiveness

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