Free androgen index and Irisin in polycystic ovary syndrome

Li, H.; Xu, Xiangdong; Wang, X.; Liao, Xin; Li, L.; Yang, Gangyi; Gao, Lin

doi:10.1007/s40618-015-0403-7

Cited by 47 publications

(52 citation statements)

References 34 publications

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“…After metformin therapy, authors observed significantly decreased irisin levels and improved insulin resistance in PCOS women. Recently, similar results were obtained by Li et al [58], who noted significantly increased irisin levels in overweight and obese PCOS women with high free androgen index (FAI) with an evident increase in insulin resistance and hyperandrogenemia, suggesting that elevated irisin levels predict insulin resistance, metabolic syndrome and hyperandrogenemia.…”

Section: New Markers: Structure Action and Role In Insulin Resistancesupporting

confidence: 79%

New markers of insulin resistance in polycystic ovary syndrome

Polak

Czyźyk

Simoncini

et al. 2016

J Endocrinol Invest

189

127

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Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in women of reproductive age. The diagnostic criteria include two out of three features: hyperandrogenism, polycystic ovaries on ultrasound and menstrual irregularities (Rotterdam Criteria 2003). PCOS patients are more vulnerable to develop diabetes, cardiovascular diseases and metabolic syndrome. Insulin resistance (IR) is prevalent in women with PCOS independently of obesity and is critically involved in reproductive and metabolic complications of the syndrome. Several tests have been developed to measure IR, some very reliable but complex like the hyperinsulinemic euglycemic glucose clamp and others less precise but easier and less invasive like HOMA-IR. New markers are needed to reach a more reliable assessment of insulin resistance. To date, several surrogate markers have been proposed in the literature to facilitate and improve the determination of IR. Many new proteins are strongly involved with PCOS physiopathology and IR, such as some adipocytokines (adiponectin, visfatin, vaspin and apelin), copeptin, irisin, PAI-1 and zonulin. Many other proteins have been proposed as potential new markers of IR in PCOS, such as resistin, leptin, RBP4, kisspetin and ghrelin, but their role is still controversial. In this review, we provide a short characterization of these new markers, recently studied as indicators of metabolic state.

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Section: New Markers: Structure Action and Role In Insulin Resistancesupporting

confidence: 79%

New markers of insulin resistance in polycystic ovary syndrome

Polak

Czyźyk

Simoncini

et al. 2016

J Endocrinol Invest

189

127

View full text Add to dashboard Cite

show abstract

“…In other studies, a worse metabolic profile in PCOS patients was associated with higher testosterone concentrations [13]. In turn, Li et al showed that higher FAI in patients with PCOS correlates with higher BMI, %fat, TC, DHEA-S and HOMA-IR [14]. Recently, Münz-ker et al suggested that increased TT/DHT ratio is a good predictor of unfavorable metabolic profile in this group of patients [4].…”

Section: Discussionmentioning

confidence: 90%

Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients

et al. 2017

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Objectives: Total testosterone/dihydrotestosterone ratio (TT/DHT) was found to determine metabolic risk in polycystic ovary syndrome (PCOS). The aim of this study was to analyze whether (TT/DHT) may be helpful in predicting metabolic risk not only in PCOS patients but also in healthy women. Material and methods:Total testosterone (TT), dihydrotestosterone (DHT), androstendione and dehydroepiandrosterone sulphate (DHEA-S) were measured by LC-MS/MS in 36 women with PCOS and in 29 age-matched controls without clinical hyperandrogenism. In all participants, anthropometric data, lipids, adipose tissue percent (%fat), HOMA-IR were also assessed. Results:The studied groups were not different in terms of age, BMI, waist circumference, %fat and HOMA-IR. In the patients group, mean TT and androstendione levels were significantly higher as compared to controls (1.4 nmol/L vs. 1.0 nmol/L, P < 0.001) and (6.6 nmol/L vs. 4.9 nmol/L, P < 0.01), respectively. In the patients group, mean TT/DHT ratio was significantly higher compared to controls (3.6 vs. 2.7, P < 0.01) and correlated with BMI (r = 0.37, P < 0.05), waist circumference (r = 0.44, P < 0.01), %fat (r = 0.30, P < 0.05), as well as with insulin levels (r = 0.38, P < 0.05) and HOMA-IR (r = 0.44, P < 0.05). The association between TT/DHT ratio and unfavorable metabolic parameters was also seen in controls. Conclusion:Total testosterone/dihydrotestosterone ratio assessed by LC-MS/MS correlates with a worse metabolic profile not only in PCOS patients, but also in healthy women.

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“…Data on the association of serum irisin with androgens in women are scarce as well. 2 Chinese studies (n = 269 and n = 301) reported a positive association between circulating irisin and androgens in women with polycystic ovary syndrome [27,28]. Circulating irisin levels have been shown to be reduced in subjects with T2DM and MS and to be inversely associated with FPG, insulin, and lipids [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Irisin and Testosterone in Men with Metabolic Syndrome

et al. 2017

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The beneficial effects of testosterone on the metabolism and body composition of men are well established but the exact mechanisms of these effects are not clearly understood. A potential explanation might lie in the hormones, secreted from skeletal muscles, named "myokines". One such myokine, irisin, has been shown to also have potential beneficial metabolic effects. The aim of this pilot study was to evaluate the association of serum testosterone with circulating serum irisin levels in men with metabolic syndrome. A total 128 men with metabolic syndrome (MS) based on the IDF criteria participated in the study. Irisin serum concentration was determined by means of ELISA. Mean age±SD of the study participants was 51.8±8.3 years. Seventy percent of the subjects had type 2 diabetes mellitus. Circulating irisin was inversely associated with serum testosterone (r=-0.279, p<0.01) and was significantly higher in subjects with hypogonadism - mean±SD 252.0±147.1 vs.172.9±92.2 ng/ml (p=0.002). ROC analysis of serum irisin value was determined for distinguishing subjects with hypogonadism (AUC=0.670). In a multiple linear regression model with BMI, FPG, age, and irisin, only BMI (β=-0.228, p=0.004) and irisin (β=-0.170, p=0.045) were variables independently associated with testosterone concentrations. Irisin is negatively associated with serum testosterone in our population sample of men with MS. This might suggest a possible involvement of myokines and testosterone with regards to the human metabolism. As no such data on this association has been reported in the literature thus far, further prospective studies are required to elucidate this correlation.

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Free androgen index and Irisin in polycystic ovary syndrome

Abstract: The elevated Irisin levels in PCOS women were associated with androgen excess. Circulating Irisin is a primary predictor of hyperandrogenism, MetS and IR in PCOS women.

Cited by 47 publications

References 34 publications

New markers of insulin resistance in polycystic ovary syndrome

New markers of insulin resistance in polycystic ovary syndrome

Total testosterone to dihydrotestosterone ratio assessed by LC-MS/MS predicts a worse metabolic profile not only in PCOS patients

Irisin and Testosterone in Men with Metabolic Syndrome

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