Free radical detoxifying systems in human colorectal cancer

Hoffman, C; Webster, Nigel R.; Wiggins, Paul A.; Chisholm, E M; Giles, G. R.; Leveson, Stephen H.

doi:10.1038/bjc.1985.18

Cited by 31 publications

(9 citation statements)

References 11 publications

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“…In the past, several studies have been performed on SOD in human colorectal carcinomas, but they almost exclusively evaluated only the activity of the enzymes. These studies provided variable results, with normal, increased, and decreased activity levels being found for both Mn-SOD and Cu/Zn-SOD in the carcinomas versus normal mucosa (Baur and Wendel 1980;Homan et al 1985;Nelson 1988;BenÄ o et al 1995). In addition, chemically induced large-bowel tumors in the rat and mouse were found to have elevated Cu/Zn-SOD levels and reduced Mn-SOD activities as compared with normal intestinal tissue (Oberley and Buettner 1979;Loven et al 1980;Sun et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Superoxide dismutases in the human colorectal cancer sequence

Janssen¹,

Bosman²,

Kruidenier³

et al. 1999

Journal of Cancer Research and Clinical Oncology

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Section: Discussionmentioning

confidence: 99%

Superoxide dismutases in the human colorectal cancer sequence

Janssen¹,

Bosman²,

Kruidenier³

et al. 1999

Journal of Cancer Research and Clinical Oncology

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“…Difficulties can arise owing to differences in the assay system, caused by variable experimental conditions, that might also be confused by SOD's species and tissue specificity (5). Such species and tissue specificity is responsible for the different SOD activities in similar disorders in different tissues, making it difficult to clarify the physiological role of each enzyme in various tissues and the relation between the two enzymes (8,20,21). In this study, the cellular localiza¬ tion and concentration of both SODs were investigated in various thyroid disorders by an immunocytochemical technique and a sensitive enzyme immunoassay system using highly purified anti-human SOD antibodies (10,11,14).…”

Section: Discussionmentioning

confidence: 99%

“…Superoxide dismutase is reported to suppress the promotion of neoplasms (7,21), but elevated SOD activity in tumors is thought to be an accommodation for the increase of Superoxide radicals produced during tumor growth (20). Irradiation or anticancer drugs also are thought to have an effect on tumors through tissue damage by Superoxide radical formation (18,19,22).…”

Section: Discussionmentioning

confidence: 99%

Localization of Cu/Zn and Mn superoxide dismutase in various thyroid disorders

Iwase

Nagasaka²,

Kato³

et al. 1993

Acta Endocrinologica

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The intracellular localization of Cu/Znand Mn-superoxide dismutases (SOD), which catalyze the dismutation of superoxide radicals (O2\m=-\) to O2 and H2O2, was studied in the thyroid tissue of various thyroid disorders by an immunohistochemical technique. The concentrations of both SODs in those tissues were measured also by a sandwich enzyme immunoassay technique.Copper/zinc-SOD in thyroid tissues were identified by immunocytochemical staining in most cases of papillary carcinoma and in some cases of other thyroid disorders. In normal follicular cells this enzyme is localized in the perinuclear cytoplasm, whereas in thyroid tumor or hyperplastic follicular cells it exists homogenously in cytoplasm. Manganese-SOD stained strongly in papillary carcinoma and papillary-growing cells in the thyroid tissue of adenoma and Graves' disease. The concentrations of Cu/ Znand Mn-SOD in thyroid tumor tissues and hyperplastic follicular disorders were significantly higher than those in normal thyroid tissue when they were compared as a function of protein or deoxyribonucleic acid contents. The ratio of Mn-SOD to Cu/Zn-SOD was significantly higher only in papillary carcinoma, except for other thyroid disorders, as compared with that in the normal thyroid. In conclusion. SOD seems to be related to cell proliferation and differentiation in the thyroid follicular cell because Cu/Zn-SOD changes its localization in tumor and hyperplastic follicular cells and because the Mn-SOD concentration is increased in papillary carcinoma or papillary-growing cells.

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“…of these enzymes in various tissues [2,3,16,17]. In the present study, the cellular distribution and the concentration of each SOD was determined in several benign adrenal tumors by an immunohistochemical technique and a sensitive enzyme immunoassay system using highly purified antihuman Cu/Zn-and Mn-SOD antibodies [11][12][13].…”

Section: Discussionmentioning

confidence: 99%