Free radical processes in the piglets organism under the humic supplements

Buchko, O.

doi:10.15407/animbiol15.01.027

Cited by 4 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In HS-added weaned pigs, reduced T-AOC and MDA were observed [63]. In piglets born from HS-added sows 2 weeks before and 1 week after farrowing, reduced TBAactive products concentration, lipid hydroperoxides, and protein carbonyl groups and increased SOD and catalase activity were found; after re-feeding HS in the older piglets, reinforced positive impact on the antioxidant defense system and free-radical processes were reported [64]. In HS-added weaning pigs, a decrease in oxidative stress was also reported after a challenge with an Escherichia (E.) coli LPS [65].…”

Section: Antioxidant Statusmentioning

confidence: 86%

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Angeles¹,

Gómez-Rosales²,

Téllez–Isaías³

2022

Humus and Humic Substances - Recent Advances

View full text Add to dashboard Cite

A review of the latest research on the addition of humic substances (HSs) in the drinking water or feed of farm animals including poultry, pigs, dairy cows and calves, goats, and rabbits was carried out. The results reinforces the promoted protective action of HS on the digestive mucosa, their antioxidant properties, immunomodulatory, and anti-inflammatory attributes, the suggested microbial shift to a probiotic-type bacteria in the gut, including antiparasitic and antifungal effects, as well as their influence on the higher efficient of minerals, proteins, and lipids utilization within the body. The outstanding improvements in health, productivity, and meat and milk quality obtained from animals supplemented with HS are common features in the majority of available research. The main benefits in the gastrointestinal tract stem from the formation of protective barriers on the epithelial mucosa due to its colloidal properties and stimulation of mucin production. HS also promotes the development of probiotic microbiota and positive changes in bacterial fermentation patterns, which results in improved intestinal health and integrity. As a result, a cascade of benefits is derived within the body, reinforcing antioxidant protection responses, immunomodulation, and anti-inflammation mechanisms, as well as improving nutrient utilization efficiency. However, the truly molecular mechanisms of action of HS in the intestine and throughout the body remain unknown.

show abstract

Section: Antioxidant Statusmentioning

confidence: 86%

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Angeles¹,

Gómez-Rosales²,

Téllez–Isaías³

2022

Humus and Humic Substances - Recent Advances

View full text Add to dashboard Cite

show abstract

“…The higher DPPH in serum found at three and seven days postweaning agree with previous research, in which reduced active TBA product concentrations and increased serum superoxide dismutase and catalase activity of HS-fed weaning pigs was reported. (24) In HS-fed weaned pigs, LPS-challenged, increased serum glutathione and reduced glutathione peroxidase was reported. (25) Reduced serum biomarkers of oxidative stress (8-iso PGE 2 and 8-iso PGF 2α ) in HS-fed weaned pigs have been also found.…”

Section: Discussionmentioning

confidence: 99%

“…(2) In piglets born from HS-added sows, reduced TBA products concentration, lipid hydroperoxides, and protein carbonyl groups and increased superoxide dismutase and catalase activity were found. (24) In weaning pigs fed a commercial source of HS and challenged with an Escherichia (E.) coli LPS, higher glutathione concentrations and lower glutathione peroxidase activities were also reported. (25) In pigs, the possibility that HS from vermicompost may improve the antioxidant response in piglets experiencing the weaning stress has not been evaluated either.…”

Section: Introductionmentioning

confidence: 99%

The addition of humic substances extracted from vermicompost enhances the growth performance and the antioxidant status of weaning pigs

Jonathan Alexander,

Gomez-Rosales,

Angeles

et al. 2023

Vet Mex OA

View full text Add to dashboard Cite

The aim of the study was to assess the effect of humic substances (HS) extracted from vermicompost on the growth performance, fecal score, bone ash content and antioxidant status in muscles and blood serum of weaned pigs from 1-42 days postweaning. Two-hundred 22-day weaned pigs were assigned to four treatments: 1= Positive control diet with colistin (PC), 2= Negative control diet without antibiotic or HS (NC), 3 and 4= Diets with 2 500 and 5 000 ppm of HS, respectively. Growth performance, fecal consistency, dry matter and ashes of metatarsus and the 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, iron reducing ability and thiobarbituric acid reactive substances in muscles and blood were registered. Results were subjected to ANOVA and regression analysis. Linear increasing responses (P < 0.05) were found in the body weight at 42 days postweaning, the ADG from 1-7, 8-21, 22-42 and 1-42 and the gain:feed ratio from 1-7, 22-42 and 1-42 days postweaning, whilst the fecal score decreased linearly (P < 0.01) from 1-7, 8-21 and 1-42 days postweaning due to the increasing dietary HS concentration. The antioxidant potential of 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity (P < 0.05) in loin muscle and blood serum at three and seven days, and in fillet muscle at seven days postweaning increased linearly due to the increasing dietary HS concentration. It is concluded that the addition of HS improved the growth performance from 1-42 days postweaning and the antioxidant status in muscles and blood serum of weaned pigs at three and seven days postweaning.

show abstract

“…Така реакція властива для багатьох біологічно активних речовин. Хоча спроби ідентифікації гормонів у складі гумінових речовин досі не увінчалися успіхом, гормоноподібна активність як природних, так і промислових препаратів не залишає сумнівів (Khristeva, 1973;Perminova, 2008;Buchko, 2011;Buchko and Maksimovic, 2011;Buchko 2013). Незважаючи на широке використання гуматів у різних галузях господарства, впровадження цих речовин у медичну та фармакологічну галузь триває.…”

Section: вступunclassified

“…За таких умов підвищується проникність мітохондрільної мембрани (Demin et al, 2008;Maltsev et al, 2010;Shmarakov et al, 2014;Donghong, 2015), внаслідок чого підвищується концентрація цитохрому С у цитозолі та знижується інтенсивність клітинного дихання, перетворення супероксиданіона на молекулярний оксиген за його участю та життєздатність клітини в цілому. Біологічно активна кормова добавка Гумілід активізує функціонування захисних систем печінки та стимулює адаптаційні процеси Buchko, 2011Buchko, , 2013, а аскорбінова кислота виступає додатковим фактором їх стимуляції та захищає гумінові кислоти від окиснення.…”

Section: результати та їх обговоренняunclassified

Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus)

2016

View full text Add to dashboard Cite

One important reason for non-use of medicinal drugs is their hepatotoxicity. The search for new natural biologically active substances with hepatoprotective properties and which are cost-effective is an important task today. This article presents the data on the impact of the fodder-dietary supplement Humilid alone and in combination with ascorbic acid, and Eco-Impulse on the liver of Mongolian gerbils (Meriones unguiculatus Milne-Edwards, 1867). Hepatomodulation of properties of humic substances in the Humilid confirmed that stimulation of the activity of the enzyme transaminase increases the total amount of protein, especially in combination with ascorbic acid. There was inhibition of accumulation of oxidized products in the cell due to activation of catalase and superoxidedismutase. Intensification of catalase is regarded as one of the important mechanisms of adaptation of the cell under the influence of xenobiotics. Addition of ascorbic acid to the solution Humilid increased the antioxidant action of its active ingredients both through its own antioxidant properties and protection of humic acids from oxidation. Formation of response in liver cells of gerbils receiving active ingredients of the drug Eco-Impulse was accompanied by an increase in the number of TBA-active products and cytochrome C, which indicates the development of oxidative stress, which is accompanied by increased permeability of mitochondrial membranes. The results indicate the hepatoprotective properties of the active ingredients of the drug Humilid, alone and in combination with ascorbic acid, and the need for correcting the concentration of the drug Eco-Impulse for use in clinical practice.

show abstract

Free radical processes in the piglets organism under the humic supplements

Abstract: 18. Czauderna M., Kowalczyk J., Niedźwiedzka K. M., Wąsowska I., Pająk J. J., Bulska E., Ruszczyńska A. The effect of linseed oil and selenium on the content of fatty acids and some elements in the liver and selected tissues of sheep.

Cited by 4 publications

References 5 publications

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

The addition of humic substances extracted from vermicompost enhances the growth performance and the antioxidant status of weaning pigs

Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus)

Contact Info

Product

Resources

About