Free Radical Scavenging Effect and Oxidative Stress Protective Activity of Domestic Processed Polygoni Multiflori Radix

김현영,; 김준영,; 조은주,; 최지명,; 황정은,; 이희율,; 안민주,; 이진환,; 김윤근,; 고건희,; 구영민,; 오경렬,; 조계만,

doi:10.3746/jkfn.2015.44.6.809

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…특히 2,3,5,4'-tetrahydroxystilbene-2-0-α-glucoside 화합물은 하수 오의 성분 중 가장 많은 양이 함유되어 있다고 보고되어 있다 [6]. 또한 하수오의 항산화 활성 등과 같은 여러 효능 외에도 chrysophanol, rhein, physcion 및 emodin과 이들 화합물의 배 당체 형태인 2,3,5,4'-tetrahydroxystilbene-2-0-α-glucoside 등의 화합물로부터 기인하여 생성되는 효과는 콜레스테롤 감소 [2], 혈 당강하작용 [2], 멜라닌 생성 억제에 의한 미백 개선효과 [7], 산 화 스트레스 개선효과 [8], 식중독 미생물(황색포도상구균) 저해 효과 [9] [16]. 또한 유산 발효의 경우 유 산균이 생성하는 대사산물에 의해 유리아미노산, 유기산 등 다 양한 물질을 생성하여 발효물의 pH 감소 및 산도 증가에 영향 을 주는 것으로 판단된다 [17].…”

Section: 서 론unclassified

Comprehensive comparison of the primary and secondary metabolites and antioxidant activity of Polygoni multiflori Radix by processing methods

Lee

Hwang²,

Hwa

et al. 2022

JABC

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This study investigated the changes in the physiochemical property, phytochemical content, nutritional content and antioxidant activity of Polygoni multiflori Radix by steam, aging, and fermentation. After processing Polygoni multiflori Radix (PMR), pH slightly decreased, while acidity increased (pH 5.70 →4.78, acidity 0.23→0.29%). The reducing sugar content increased after aging and fermentation from 1.19 mg/g (PMR) to 1.40 (fermented PMR, FPMR), 1.30 (red PMR, RPMR), 1.53 (fermented red PMR, FRPMR), 1.99 (black PMR, BPMR), and 2.33 mg/g (fermented black PMR, FBPMR). Total phenolic content was highest in PMR (6.05 mg/g) and total flavonoids and maillard product were increased after aging and fermentation of PMR, and were the highest in BPMR (1.60 mg/g) and FBPMR (2.76 O.D.), respectively. The major phytochemical was 2,3,5,4ʹtetrahydroxystilbene-2-0-α-glucoside, which were highest in PMR (64.9 mg/g) with 46.47 mg/g at FPMR, 33.94 mg/g at RPMR, 48.76 mg/g at FRPMR, 36.68 mg/g at BPMR and 34.35 mg/g at FBPMR. The main fatty acids and free amino acids were detected as palmitic acid (C16:0) and proline, respectively. Generally, 2,2diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical scavenging activities and FRAP reducing powers were shown high in PMR (39.06%, 98.32%, and 2.61 O.D. in extracts concentration 1.0 mg/ mL), then were decreased after aging and fermentation.

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Section: 서 론unclassified

Comprehensive comparison of the primary and secondary metabolites and antioxidant activity of Polygoni multiflori Radix by processing methods

Lee

Hwang²,

Hwa

et al. 2022

JABC

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“…The TSG compound accounted for approximately 96% of PPM. Several researchers have reported that the TSG compound accounts for >95% of PPM [16,18].…”

Section: Phytochemical Contents Of Ppmmentioning

confidence: 99%

“…Hence, PPM is considered relatively safe and has attracted increasing attention as a promising therapeutic agent instead of PM [13,15]. Moreover, 2,3,5,4′-tetrahydroxystilbene-2-O-β-glucoside (TSG), a monomer of stilbene, is an important component isolated from PPM [16]. Therefore, we used TSG in the present study as a standard constituent of PPM.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Processed Polygoni multiflori Radix and Its Major Substance during Scopolamine-Induced Cognitive Dysfunction

Kim

et al. 2021

Processes

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Alzheimer’s disease (AD) is the most common cognitive disorder in the elderly population. However, effective pharmacological agents targeting AD have not been developed. The processed Polygoni multiflori Radix (PPM) and its main active substance, 2,3,5,4′-tetrahydroxystilbene-2-O-β-glucoside (TSG), has received considerable attention, majorly due to its neuroprotective activities against multiple biological activities within the human body. In this study, we provide new evidence on the therapeutic effect of PPM and TSG during cognitive impairment by evaluating the ameliorative potential of PPM and TSG in scopolamine-induced amnesia in ICR mice. PPM (100 or 200 mg/kg) was orally administered during the experimental period (days 1–15), and scopolamine was intraperitoneally injected to induce cognitive deficits during the behavioural test periods (days 8–15). The administration of PPM and TSG significantly improved memory loss and cognitive dysfunction in behavioural tests and regulated the cholinergic function, brain-derived neurotrophic factor, and neural apoptosis. The present study suggests that PPM and TSG improved scopolamine-induced cognitive dysfunction, but further study has to be supported for the clinical application of PPM and TSG for AD prevention and treatment.

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“…Furthermore, antioxidative compounds can be derived from chrysophanol, rhein, physcion, emodin, and TSG. Apart from their antioxidative activities, these compounds have been shown to reduce cholesterol [ 4 ] and blood sugar [ 4 , 15 ] levels, have a whitening improvement effect by inhibiting melanin production [ 15 , 16 ], and reduce oxidative stress [ 17 ]. They also inhibit microorganisms that cause food poisoning, such as Staphylococcus aureus [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Verification of the Field Productivity and Bioequivalence of a Medicinal Plant (Polygonum multiflorum) Developed Using an In Vitro Culture Method

Kim

Komakech

Jeong

et al. 2020

Plants

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Polygonum multiflorum Thunb. is a perennial plant that belongs to Polygonaceae. Root tissues are the main plant parts used as medicinal herbs in Korean oriental medicine. The P. multiflorum tuber is well known for its medicinal properties in Korean oriental medicine, and it contains a number of useful substances (secondary metabolites of emodin, 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), etc.) that are increasing in demand, as several studies show that they have beneficial effects on the human body. In this study, the production volumes and useful material content differences between cultured P. multiflorum seedlings (culture seedlings: CSs), which had been grown using a tissue culture technique under optimized conditions, and existing varieties in circulation (seed seedlings: SSs) were determined using a long-term field test. The growth characteristics of the underground parts were investigated by harvesting the tuberous roots (medicinal parts) after 1 year, and the results showed that the fresh and dry weights of the CS tubers were higher than those of the SS tubers. However, the SS rootlets had higher fresh and dry weights than the CS rootlets. A liquid chromatography-mass spectrometry component analysis of the P. multiflorum tubers and a Fourier transform near-infrared spectrophotometer analysis of the roots were undertaken. The results showed that the levels of TSG, which is a medicinal substance produced by P. multiflorum, were higher in the CSs than in the SSs, but the differences were not significant. The CS results from this study will inform future studies on the mass production of P. multiflorum in the field because the medicinal area was greater in CSs than in SSs.

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Free Radical Scavenging Effect and Oxidative Stress Protective Activity of Domestic Processed Polygoni Multiflori Radix

Cited by 8 publications

References 41 publications

Comprehensive comparison of the primary and secondary metabolites and antioxidant activity of Polygoni multiflori Radix by processing methods

Comprehensive comparison of the primary and secondary metabolites and antioxidant activity of Polygoni multiflori Radix by processing methods

Protective Effect of Processed Polygoni multiflori Radix and Its Major Substance during Scopolamine-Induced Cognitive Dysfunction

Verification of the Field Productivity and Bioequivalence of a Medicinal Plant (Polygonum multiflorum) Developed Using an In Vitro Culture Method

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