Free Triiodothyronine Level Indicates the Degree of Myocardial Injury in Patients with Acute Myocardial Infarction

doi:10.20431/2455-7153.0301003

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“…In line with these results, a recent study with patients attending a cardiac rehabilitation program after an acute coronary syndrome also reported an association between lower T3 levels and all-cause mortality (96). In patients with myocardial injury, lower T3 levels have been correlated with increased serum levels of cardiac biomarkers such as troponin T and N-terminal pro-brain natriuretic peptide and with lower left ventricular ejection fraction (97). T3 levels may represent a predictor of the potential recovery of ventricular function (94).…”

Section: The Impact Of Thyroid Hormone Dysfunction On Myocardial Ischmentioning

confidence: 99%

The impact of thyroid hormone dysfunction on ischemic heart disease

Hafe

Neves

Vale

et al. 2019

Endocrine Connections

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Thyroid hormones have a central role in cardiovascular homeostasis. In myocardium, these hormones stimulate both diastolic myocardial relaxation and systolic myocardial contraction, have a pro-angiogenic effect and an important role in extracellular matrix maintenance. Thyroid hormones modulate cardiac mitochondrial function. Dysfunction of thyroid axis impairs myocardial bioenergetic status. Both overt and subclinical hypothyroidism are associated with a higher incidence of coronary events and an increased risk of heart failure progression. Endothelial function is also impaired in hypothyroid state, with decreased nitric oxide-mediated vascular relaxation. In heart disease, particularly in ischemic heart disease, abnormalities in thyroid hormone levels are common and are an important factor to be considered. In fact, low thyroid hormone levels should be interpreted as a cardiovascular risk factor. Regarding ischemic heart disease, during the late post-myocardial infarction period, thyroid hormones modulate left ventricular structure, function and geometry. Dysfunction of thyroid axis might even be more prevalent in the referred condition since there is an upregulation of type 3 deiodinase in myocardium, producing a state of local cardiac hypothyroidism. In this focused review, we summarize the central pathophysiological and clinical links between altered thyroid function and ischemic heart disease. Finally, we highlight the potential benefits of thyroid hormone supplementation as a therapeutic target in ischemic heart disease.

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Section: The Impact Of Thyroid Hormone Dysfunction On Myocardial Ischmentioning

confidence: 99%