Free-water diffusion tensor imaging detects occult periependymal abnormality in the AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

Kim, Min‐Chul; Choi, Kyu Sung; Hyun, Ryoo Chang; Hwang, In-Kyeong; Yun, Tae Jin; Kim, Sung Min; Kim, Ji-Hoon

doi:10.1038/s41598-021-04490-3

Cited by 2 publications

(1 citation statement)

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“…Regarding tSNR, a method used to quickly screen the overall data quality, the participants’ lowest value was 7.57, which is above the suggested cutoff value (6.47) for poor data (Roalf et al, 2016 ). Free‐water corrected DTI maps were calculated using an in‐house MATLAB script that was previously used in this study cohort (Bergamino et al, 2017 ; Bergamino et al, 2021 ; Kim et al, 2022 ). Finally, we acquired the mean of the FW index of each participants’ white matter skeleton (Andica et al, 2023 ) (Figure 2 ).…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging

Kim,

Hwang,

Park

et al. 2024

Human Brain Mapping

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ObjectiveThe glymphatic system is a glial‐based perivascular network that promotes brain metabolic waste clearance. Glymphatic system dysfunction has been observed in both multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), indicating the role of neuroinflammation in the glymphatic system. However, little is known about how the two diseases differently affect the human glymphatic system. The present study aims to evaluate the diffusion MRI‐based measures of the glymphatic system by contrasting MS and NMOSD.MethodsThis prospective study included 63 patients with NMOSD (n = 21) and MS (n = 42) who underwent DTI. The fractional volume of extracellular‐free water (FW) and an index of diffusion tensor imaging (DTI) along the perivascular space (DTI–ALPS) were used as indirect indicators of water diffusivity in the interstitial extracellular and perivenous spaces of white matter, respectively. Age and EDSS scores were adjusted.ResultsUsing Bayesian hypothesis testing, we show that the present data substantially favor the null model of no differences between MS and NMOSD for the diffusion MRI‐based measures of the glymphatic system. The inclusion Bayes factor (BF10) of model‐averaged probabilities of the group (MS, NMOSD) was 0.280 for FW and 0.236 for the ALPS index.ConclusionTogether, these findings suggest that glymphatic alteration associated with MS and NMOSD might be similar and common as an eventual result, albeit the disease etiologies differ.Practitioner Points Previous literature indicates important glymphatic system alteration in MS and NMOSD. We explore the difference between MS and NMOSD using diffusion MRI‐based measures of the glymphatic system. We show support for the null hypothesis of no difference between MS and NMOSD. This suggests that glymphatic alteration associated with MS and NMOSD might be similar and common etiology.

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Section: Methodsmentioning

confidence: 99%

Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging

Kim,

Hwang,

Park

et al. 2024

Human Brain Mapping

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Patterns of Adult Neuromyelitis Optica Spectrum Disorder Patients Compared to Multiple Sclerosis: A Systematic Review and Meta-Analysis

Alqwaifly,

Althobaiti,

AlAibani

et al. 2023

Cureus

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Neuromyelitis optica spectrum disorders (NMOSDs) are central nervous system inflammatory conditions, now recognized to involve the brain, often identified by aquaporin-4 (AQP4) antibodies. We aimed to summarize the characteristics of adult NMOSD patients compared to multiple sclerosis (MS). A computerized search was conducted on MEDLINE via PubMed, Web of Science, and ProQuest using the relevant keywords. Three independent reviewers performed two-stage screening and data extraction. The Review Manager 5.4 program (Cochrane Collaboration, Windows, London, UK) was used for the analysis. The Joanna Briggs Institute (JIB) tool was used for the quality of included studies. Twenty-three articles were included. NMOSD patients were associated with older age at presentation and higher Expanded Disability Status Scale (MD = 3.88, 95% CI: 1.80 to 5.97, P = 0.0003) and (MD = 1.15, 95% CI: 0.58 to 1.72, P < 0.0001), respectively. The risk of NMOSD in females was significantly higher than MS (OR = 2.21, 95% CI: 1.41 to 3.46, P = 0.0005). Patients with NMOSD were associated with a lower risk of extrapyramidal symptoms (OR = 0.26, 95% CI: 0.11 to 0.60, P < 0.01), brainstem involvement symptoms (OR = 0.32, 95% CI: 0.16 to 0.64, P < 0.01), and developing brain lesions compared to MS (OR = 0.08, 95% CI: 0.03 to 0.18, P < 0.00001). The current evidence suggests that both NMOSD and MS have different demographic, clinical, and lesion characteristics. There is a need for additional validation of the identified differences compared with MS due to the lack of long-term systematic imaging investigations in NMOSD.

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Free-water diffusion tensor imaging detects occult periependymal abnormality in the AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

Cited by 2 publications

References 45 publications

Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging

Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging

Patterns of Adult Neuromyelitis Optica Spectrum Disorder Patients Compared to Multiple Sclerosis: A Systematic Review and Meta-Analysis

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