Frequency and distribution of HPV genotypes in 800 genital samples of Ecuadorian men and women from the city of Guayaquil

Muentes, Gustavo David García; García, Marcia Adelaida Mendoza; Galárraga, Ramiro Israel Burgos; Ollague, Kleber; Wachter, Cynthia Vargas; Cabezas, J.

doi:10.1590/s1678-9946201961041

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…In a study carried out on men with partners who presented cervical intraepithelial lesions, 41.9% of positive samples were found [ 98 ], while in another study carried out on young men under 25 years, the positive samples reached 51.8%; these last data are somewhat related to reports in women of the same age range in whom the percentage of positivity is higher too [ 85 ]. Similar data were reported in a study in Ecuador in which the percentage of positive men was approximately 63.5%, much higher than what was reported in women in the same study (39.5%) and, although they did not analyze the prevalence by age and sex, it can be seen that the percentage of positive samples is higher in the 18–30-year-old group [ 97 ].…”

Section: Hpv and Cervical Cancer In Latin Americasupporting

confidence: 87%

“…The male population plays a fundamental role in the development of CC since it has been seen that men present a higher percentage of positive samples compared to women. In addition, it has been seen that they present many genotypes that cover current vaccines [ 97 , 98 ], so including them in the vaccination plan could be a favorable situation in the fight against CC.…”

Section: Future Directions and Recommendationsmentioning

confidence: 99%

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HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

Hernández-Silva,

Ramírez de Arellano,

Pereira-Suárez

et al. 2024

Viruses

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Cervical cancer is primarily caused by Human Papillomavirus (HPV) infection and remains a significant public health concern, particularly in Latin American regions. This comprehensive narrative review addresses the relationship between Human Papillomavirus (HPV) and cervical cancer, focusing on Latin American women. It explores molecular and immunological aspects of HPV infection, its role in cervical cancer development, and the epidemiology in this region, highlighting the prevalence and diversity of HPV genotypes. The impact of vaccination initiatives on cervical cancer rates in Latin America is critically evaluated. The advent of HPV vaccines has presented a significant tool in combating the burden of this malignancy, with notable successes observed in various countries, the latter due to their impact on immune responses. The review synthesizes current knowledge, emphasizes the importance of continued research and strategies for cervical cancer prevention, and underscores the need for ongoing efforts in this field.

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Section: Hpv and Cervical Cancer In Latin Americasupporting

confidence: 87%

Section: Future Directions and Recommendationsmentioning

confidence: 99%

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

Hernández-Silva,

Ramírez de Arellano,

Pereira-Suárez

et al. 2024

Viruses

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“…Comparatively in Ecuador, prevalence by strain contributing to invasive cervical cancer ranks HPV 16, 58, 52, 31, 59, 39 in decreasing frequency (21). Another study carried out in Cañar, a region of the Ecuadorian highlands, confirms a shift in infection patterns towards hrHPV 31, 58, 59, and 66 in around 20% of the infected women (22). A study conducted in the city of Guayaquil between 2015-2018 in 800 participants from the Ecuadorian coast found a high percentage of infection by non 16-18 HPV strains in men and women (51.38%) (23).…”

Section: Discussionmentioning

confidence: 89%

Biological, demographic, and health factors associated with HPV infection in Ecuadorian women

Roman,

Andrade,

Hernández

et al. 2023

Front. Public Health

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ObjectivesThe study aims to identify the correlation between human papillomavirus (HPV) infection and sociodemographic and sexual reproductive health factors in Ecuadorian women from March to August 2019.Methods120 women were randomly selected from two gynecological clinics to complete a questionnaire and provide a biospecimen. PCR-Hybridization was used to genotype 37 HPV serotypes in samples obtained by endo-cervical brushing for liquid-based cytology. Sociodemographic and sexual health data were collected through a validated questionnaire during a medical consultation. Mathematical modeling of HPV infection was done using bivariate logistic regression.Results65.0% of the women sampled had an HPV infection; 74.3% of these women had co-infections with other HPV genotypes. Out of the women who were HPV positive, 75.6% were diagnosed with high-risk genotypes from HPV strains 18, 35, 52, and 66. Parity, immunosuppression, and use of oral contraception/intrauterine devices (IUDs) were identified as associated variables. The explanatory model had a sensitivity of 89.5% and a specificity of 73.8%.ConclusionThe predominant strains of HPV among Ecuadorian women are diverse. The risk of HPV infection is a complex phenomenon where biological and psychosocial variables are integrated into a model. In populations with limited access to health services, low socioeconomic status, and negative sociocultural beliefs about sexually transmitted infections (STIs), surveys can be used as a pre-screening step for HPV infections. The diagnostic value of the model should be tested in multicenter studies that include women from all over the country.

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“…Ahora bien, al considerar a la prevalencia en Ecuador y aunque los artículos publicados son pocos en el país, sin embargo, los autores (Muentes et al, 2019), en la investigación transversal que realizaron en el Instituto Oncológico Nacional de la Sociedad de Lucha Contra el Cáncer en Guayaquil, lograron identificar que de las 400 mujeres, las muestras positivas del AND del VPH fueron del 39,50% destacando los genotipos en orden de mayor a menor de prevalencia el 39, 16, 6 y 58. Es decir, que predominaron los genotipos de alto riesgo.…”

Section: Discussionunclassified

Virus del papiloma humano, prevalencia, factores de riesgo y diagnóstico en mujeres adultas

Mera-Álava,

Velásquez-Pinargote,

Castro-Jalca

2024

MQRInvestigar

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El Virus de Papiloma Humano es conocido como aquel que causa alteraciones en las células e infecta a las mucosas genitales y sexuales, su transmisión es principalmente sexual con una amplia genotificación denominados virus de papiloma humano de alto riesgo y bajo riesgo, asimismo es el principal causante de anomalías en el cuello uterino o cáncer en la mujer. El estudio tuvo como objetivo analizar la prevalencia, factores de riesgo y el diagnóstico del virus de papiloma humano en las mujeres adultas, con metodología de diseño documental narrativo de tipo descriptivo en bases de datos internacionales y nacionales. La prevalencia identificada a nivel mundial en los estudios mantiene variaciones en sus cifras, en donde se identificó el 78% en Brasil y el 10,2% en Croacia, predominando los tipos de alto riesgo (16, 18, 58 y 59). En Ecuador en otros estudios esta prevalencia fue de 39,50% hasta el 79% (Guayaquil y Cuenca respectivamente). Se identificó la existencia de algunos factores incidentes, predominando aquellos de conducta sexual, mantener varias parejas o que esta no sea estable, el nivel educativo, civil o por otras enfermedades que debilitan el sistema inmunológico. El diagnóstico de laboratorio se basa en técnicas de citología y moleculares (Papanicolaou, Reacción en Cadena de la Polimerasa, Hibridación). Se puede concluir que este virus sigue manteniendo su prevalencia, en algunos países es más alta, siendo conveniente seguir realizando investigaciones con un enfoque epidemiológico, identificando factores e incentivando a su vez los controles rutinarios en las mujeres adultas para su prevención.

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Frequency and distribution of HPV genotypes in 800 genital samples of Ecuadorian men and women from the city of Guayaquil

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 7 publications

References 28 publications

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women

Biological, demographic, and health factors associated with HPV infection in Ecuadorian women

Virus del papiloma humano, prevalencia, factores de riesgo y diagnóstico en mujeres adultas

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