Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus

Ferreira, Vera S. G.; Pernambuco, Ricardo B.; Lopes, Edmundo Pessoa; Morais, Clarice Neuenschwander Lins de; Rodrigues, Marbiana C.; Arruda, Maria Juliana; Silva, Lidiane Moura e; Vilar, Lúcio

doi:10.1590/s0004-27302010000400004

Cited by 37 publications

(28 citation statements)

References 40 publications

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“…Almost half of patients with type 2 diabetes mellitus were found to have NAFLD, and they have more elevated BMI, as well as higher levels of aminotransferases, γ-GT, uric acid, TNF-α, insulin and HOMA-IR than subjects without NAFLD (36) . A possible pathogenic link between diabetes and NASH involves advanced glycation end products.…”

Section: Diabetesmentioning

confidence: 99%

Metabolic syndrome and risk factors for non-alcoholic fatty liver disease

Souza

Diniz

Medeiros-Filho

et al. 2012

Arq. Gastroenterol.

181

128

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-Context -Non-alcoholic fatty liver disease (NAFLD), hepatic manifestation of metabolic syndrome, has been considered the most common liver disease nowadays, which is also the most frequent cause of elevated transaminases and cryptogenic cirrhosis. The greatest input of fatty acids into the liver and consequent increased beta-oxidation contribute to the formation of free radicals, release of inflammatory cytokines and varying degrees of hepatocytic aggression, whose histological expression may vary from steatosis (HS) to non-alcoholic steatohepatitis (NASH). The differentiation of these forms is required by the potential risk of progression to cirrhosis and development of hepatocellular carcinoma. Objective -To review the literature about the major risk factors for NAFLD in the context of metabolic syndrome, focusing on underlying mechanisms and prevention. Method -PubMed, MEDLINE and SciELO data basis analysis was performed to identify studies describing the link between risk factors for metabolic syndrome and NAFLD. A combination of descriptors was used, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, metabolic syndrome and risk factors. At the end, 96 clinical and experimental studies, cohorts, meta-analysis and systematic reviews of great impact and scientific relevance to the topic, were selected. Results -The final analysis of all these data, pointed out the central obesity, type 2 diabetes, dyslipidemia and hypertension as the best risk factors related to NAFLD. However, other factors were highlighted, such as gender differences, ethnicity, genetic factors and the role of innate immunity system. How these additional factors may be involved in the installation, progression and disease prognosis is discussed. Conclusion -Risk factors for NAFLD in the context of metabolic syndrome expands the prospects to 1) recognize patients with metabolic syndrome at high risk for NAFLD, 2) elucidate pathways common to other co-morbidities, 3) determine risk factors associated with a worse prognosis, 4) develop therapeutic strategies with goal of reducing risk factors, 5) apply acquired knowledge in public health policies focusing on preventive strategies. HEADINGS -Metabolic syndrome X. Fatty liver, non-alcoholic. Risk factors.

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Section: Diabetesmentioning

confidence: 99%

Metabolic syndrome and risk factors for non-alcoholic fatty liver disease

Souza

Diniz

Medeiros-Filho

et al. 2012

Arq. Gastroenterol.

181

128

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“…Some parameters such as the presence of diabetes mellitus (DM), overweight, obesity, insulin resistance (IR), and liver enzyme abnormalities may suggest the existence of NAFLD (12,22,24) . Coronary artery disease (CAD) and they have been associated with the severity, progression and mortality in patients with NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease in Patients With Coronary Disease From a Brazil Northeast Area

Vilar

Cotrim

Florentino

et al. 2015

Arq. Gastroenterol.

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“…Insulin resistance plays a central role in the net retention of lipids, particularly triglycerides by the hepatocyte. Insuline resistance has consequences in the metabolism of fatty acids and carbohydrates, resulting in fatty liver, changes that, in turn, lead to the aggravation of insuline resistance [13][14][15].…”

Section: Nutritional and Intestinal Disordersmentioning

confidence: 99%

Is the Non-Alcoholic Fatty Liver Disease Part of Metabolic Syndrome?

Sur¹,

Aurelia²,

Donca³

et al. 2015

J Diabetes Metab

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Non-alcoholic fatty liver disease (NAFLD) is caused by fatty infiltration of the liver in the absence of alcohol consumption. The incidence of NAFLD in general population is 30-40%. NAFLD is considered by some authors to be the liver manifestation of the metabolic syndrome and by other authors is considered to be a separate entity. The pathogenesis of NAFLD and metabolic syndrome seems to have common pathophysiological mechanisms, with focus on insulin resistance as a key factor. Insulin resistance seems to explain the accumulation of triglycerides in the liver, being the main pathogenetic link involved in the onset and progression of NAFLD. The natural evolution is not well known, and there is some controversy about the progression from NAFL to NASH and fibrosis. Current data on epidemiology, pathophysiology and diagnostic supports the association of non-alcoholic fatty liver disease as a possible component in the cluster of metabolic syndrome. Clinical, experimental and epidemiological studies argue that NAFLD may be the hepatic manifestation of metabolic syndrome.

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Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus

Cited by 37 publications

References 40 publications

Metabolic syndrome and risk factors for non-alcoholic fatty liver disease

Metabolic syndrome and risk factors for non-alcoholic fatty liver disease

Nonalcoholic Fatty Liver Disease in Patients With Coronary Disease From a Brazil Northeast Area

Is the Non-Alcoholic Fatty Liver Disease Part of Metabolic Syndrome?

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