Frequency and Risk Factors for Barrett’s Esophagus in Taiwanese Patients: A Prospective Study in a Tertiary Referral Center

Kuo, Chia Jung; Lin, Cheng Hui; Liu, Nai Jen; Wu, Ren‐Chin; Tang, Jui Hsiang; Cheng, Ching‐Yi

doi:10.1007/s10620-009-0872-7

Cited by 32 publications

(44 citation statements)

References 31 publications

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“…In a multicentre prospective Korean study, male gender (OR 1.82; 95% CI 1.32 to 2.50) and older age (>60 vs <40 years) (OR 1.81; 95% CI 1.07 to 3.09) were significant risk factors 141. In a prospective study from Taiwan, Kuo et al 150 reported that GORD duration longer than 5 years (OR 4.2; 95% CI 1.2 to 4.8) was an independent risk factor for BO. Abdominal obesity has been implicated as a risk factor for BO both in the Western world and in Asia 151 152.…”

Section: Resultsmentioning

confidence: 96%

“…Rajendra et al 149 reported that within Malaysia, a multi-ethnic Asian country, BO was significantly more common in Indians than in Chinese and Malays. Similar to the Western world, older age, male gender and long duration of reflux symptoms have been associated with BO 136 138 141 145 150. In a multicentre prospective Korean study, male gender (OR 1.82; 95% CI 1.32 to 2.50) and older age (>60 vs <40 years) (OR 1.81; 95% CI 1.07 to 3.09) were significant risk factors 141.…”

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus

Fock

Talley

Goh

et al. 2016

Gut

157

214

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 97%

Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus

Fock

Talley

Goh

et al. 2016

Gut

157

214

View full text Add to dashboard Cite

“…We assessed the quality of each study and found that: 1) only 1 study was population based 68 ; 2) no study had an unbiased sampling frame; 3) all studies had >200 subjects); 4) all studies used standard measures for BE definition; 5) no study used outcomes evaluated by unbiased assessors; 6) only 2 studies reported the response rate, and in both it was >70% 41, 51 ; 7) all studies reported or calculated the 95% CI, and performed subgroup analyses; and 8) all but 2 studies 56 described study subjects. The overall study quality measure ranged from a score of 3 to a score of 5 (of a maximum of 8), with a mean of 4.0.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Barrett’s Esophagus in Asian Countries: A Systematic Review and Meta-analysis

Shiota

Singh

Anshasi

et al. 2015

Clinical Gastroenterology and Hepatology

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Background & Aims The prevalence and risk factors of Barrett’s esophagus (BE) in Asian countries are unclear. Studies report a wide range of BE prevalence in Asian countries. We conducted a systematic review and meta-analysis to examine the prevalence of BE, its temporal changes and risk factors in Asian countries. Methods Two investigators performed independent literature searches using PubMed and EMBASE databases, and subsequent data abstraction for studies had to meet several set inclusion and exclusion criteria. Pooled BE prevalence was calculated using a random-effect model. Estimates of relative risk for possible risk or protective factors were also calculated. Results A total of 51 studies (N = 453,147), mainly from Eastern Asia, were included. The pooled prevalence of endoscopic BE was 7.8% (95% CI = 5.0 – 12.1; 23 studies) and of histologically confirmed BE was 1.3% (95% CI = 0.7 – 2.2; 28 studies). Most (82.1%) of histologic BE was short-segment BE (<3 cm). There was a trend toward an increase in prevalence of BE over time from 1991 to 2014, especially in Eastern Asian countries. Within BE cohorts, pooled prevalence of low-grade dysplasia, high-grade dysplasia and esophageal adenocarcinoma was 6.9%, 3.0% and 2.0%, respectively. Reflux symptoms, male sex, hiatus hernia, and smoking were associated with a significantly increased risk of histologic BE in patients with BE compared with patients without BE. However, half of the patients with histologic BE did not have reflux symptoms. Conclusions BE is not uncommon in Asian countries and seems to share similar risk factors and potential for neoplastic progression to that seen in Western countries.

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“…[23] Other previous studies, to our knowledge, have analyzed the association of these medications only with the development of esophageal adenocarcinoma[7,9] or have used convenience samples and endoscopy controls, without population controls. [16,24–26]…”

Section: Discussionmentioning

confidence: 99%

Aspirin and Nonsteroidal Anti-Inflammatory Drug Use and the Risk of Barrett’s Esophagus

2014

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Background The use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the risk of esophageal adenocarcinoma; however, it is unknown where these agents may act in the proposed pathway from normal mucosa to Barrett’s esophagus to esophageal adenocarcinoma. Aim To evaluate the association between aspirin and NSAID use and Barrett’s esophagus in a case-control study within a large community-based population. Methods We conducted a case-control study of aspirin/NSAID use and Barrett’s esophagus within the Kaiser Permanente Northern California population. Cases had a new diagnosis of Barrett’s esophagus between October 2002 and September 2005; controls were members without a diagnosis of Barrett’s esophagus. Aspirin/NSAID “users” were persons with at least weekly use of either aspirin or NSAIDs in the year prior to the index date. Results Persons with Barrett’s esophagus were less likely to use aspirin than population controls (odds ratio [OR]=0.59, 95% confidence interval [CI] 0.39–0.87); a stronger association was found among cases and controls with reflux symptoms (OR=0.49, 95% CI 0.32–0.75; p-value interaction=0.004). Similar associations were found with use of either aspirin and/or non-aspirin NSAIDs) (OR= 0.53, 95% CI 0.35–0.81), although NSAID use alone was not significantly associated with Barrett’s esophagus (OR=0.74, 95% CI 0.47–1.16). The strength of the association was highest among persons with at least moderate to high total medication intake. Conclusions Regular use of aspirin or NSAIDs was associated with a decreased risk of Barrett’s esophagus, particularly among persons with GERD symptoms. These findings have implications for chemoprevention, as some of the previously described protective association between aspirin/NSAIDs and esophageal adenocarcinoma may be explained by events that occur prior to the development of Barrett’s esophagus.

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Frequency and Risk Factors for Barrett’s Esophagus in Taiwanese Patients: A Prospective Study in a Tertiary Referral Center

Abstract: There is a 3.8% frequency of BE in Taiwanese GERD patients. Hiatal hernia and prolonged GERD duration are significant risk factors.

Cited by 32 publications

References 31 publications

Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus

Asia-Pacific consensus on the management of gastro-oesophageal reflux disease: an update focusing on refractory reflux disease and Barrett's oesophagus

Prevalence of Barrett’s Esophagus in Asian Countries: A Systematic Review and Meta-analysis

Aspirin and Nonsteroidal Anti-Inflammatory Drug Use and the Risk of Barrett’s Esophagus

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