Frequency-dependent circuits anchored in the dorsal and ventral left anterior insula

Abstract

The hub role of the right anterior insula (AI) has been emphasized in cognitive neurosciences and been demonstrated to be frequency-dependently organized. However, the functional organization of left AI (LAI) has not been systematically investigated. Here we used 100 unrelated datasets from the Human Connectome Project to study the frequency-dependent organization of LAI along slow 6 to slow 1 bands. The broadband functional connectivity of LAI was similar to previous findings. In slow 6-slow 3 bands, both dorsal and ventral seeds in LAI were correlated to the salience network (SN) and language network (LN) and anti-correlated to the default mode network (DMN). However, these seeds were only correlated to the LAI in slow 2-slow 1 bands. These findings indicate that broadband and narrow band functional connections reflect different functional organizations of the LAI. Furthermore, the dorsal seed had a stronger connection with the LN and anti-correlation with DMN while the ventral seed had a stronger connection within the SN in slow 6-slow 3 bands. In slow 2-slow 1 bands, both seeds had stronger connections with themselves. These observations indicate distinctive functional organizations for the two parts of LAI. Significant frequency effect and frequency by seed interaction were also found, suggesting different frequency characteristics of these two seeds. The functional integration and functional segregation of LDAI and LVAI were further supported by their cognitive associations. The frequency- and seed-dependent functional organizations of LAI may enlighten future clinical and cognitive investigations.

Predicting behavior through dynamic modes in resting-state fMRI data

“…Actually, a previous study reported that the major frequency contributions to resting-state FC resulted from fluctuations <0.1 Hz (Cordes et al, 2001). Furthermore, RSNs have also been observed in the 0.1-0.2 Hz band (Wu et al, 2008;Salvador et al, 2008;Baria et al, 2011;Niazy et al, 2011;Gohel and Biswal, 2015;Wang et al, 2018Wang et al, , 2020. These previous findings are consistent with our results.…”

“…These previous findings are consistent with our results. However, other previous studies found RSNs in frequency bands of >0.2 Hz (Lee et al, 2013; Boubela et al, 2013; Gohel and Biswal, 2015; Wang et al, 2020). The inconsistency between the previous results and our results may imply that it is difficult to extract DMs that have a spatial structure similar to those of RSNs in the high-frequency range.…”

Abnormal Whole Brain Functional Connectivity Pattern Homogeneity and Couplings in Migraine Without Aura

“…The previous studies have demonstrated that chronic pain patients showed increased high-frequency BOLD oscillations (0.12-0.20 Hz) in the medial prefrontal cortex and parts of default mode network (Baliki et al, 2011). Recently, frequency-dependent bilateral anterior insular networks were identified (Wang et al, 2018b(Wang et al, , 2020c. In our study, decreased FcHo and functional connectivities of default mode network in the frequency band of 0.01-0.1 Hz were found suggesting that the functional abnormalities of the default mode network are present in both low and high frequencies.…”

“…Additionally, we also found abnormal FcHo and functional connectivities in sensorimotor and salience networks in the frequency band of 0.01-0.1 Hz. Given the frequency-dependent functional circuits of salience network (Wang et al, 2018b(Wang et al, , 2020c, whether the differences in the two networks are frequency-specific needs to be further investigated in future studies.…”

A fronto-insular-parietal network for the sense of body ownership

“…Our ndings indeed revealed that frontal and insular disconnections play a crucial role in the emergence of DSO. The role of the insula in the sense of body ownership is well known 10,22,27 , interpreted either as contributing to the integration of interoceptive sensations with other signals about the body 10 , or as regulating the salience of sensory signals 9,40 , including during belief updating about sensory states 41 and self-awareness 33 . Indeed, the insula is also part of the salient network, a large-scale brain network identi ed in resting state fMRI studies and connectivity analyses and thought also to relate to the ventral attention network (VAN 42 ), involving the temporoparietal junction and the ventral frontal cortex, connected by the ventral branch of the SLF.…”