FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA

Валериевна, Понасенко Анастасия; Головкин, А. С.; Шабалдин, А. В.; Цепокина, А. В.

doi:10.15789/1563-0625-2015-2-151-158

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В исследованиях, проведенных российскими учеными, отмечается, что полиморфные варианты гена ADBR1 (Gly389Arg и Gly49Ser) у пациентов с хронической РБС ассоциированы с дилатацией левых отделов сердца [16]. Кроме того, в одном из последних исследований сообщается, что с наибольшими линейными размерами левого желудочка у пациентов с хронической РБС ассоциированы гомозиготные генотипы АА гена TNF-α и АА гена IL17A [17].…”

Section: ключевые моменты Key Messagesunclassified

Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease

et al. 2022

Self Cite

View full text Add to dashboard Cite

Aim. To assess the contribution of polymorphic variants of inflammatory response genes to the predisposition to rheumatic heart disease.Material and methods. Using real-time polymerase chain reaction, we analyzed the prevalence of 18 polymorphic variants of 8 genes involved in the inflammatory process in 251 patients with rheumatic heart disease and 300 healthy donors.Results. We found that homozygous TT genotypes of rs1800871 (IL10) (p=0,02) and TT rs1800872 (IL10) polymorphisms (p=0,027), as well as TT genotypes of CRP gene (rs1205) (p=0,015) and GG genotypes of rs375947 (IL12RB) (p=0,037) are "risky" and associated with the development of rheumatic heart disease.Conclusion. Associations of polymorphic variants rs1800871 and rs1800872 of the IL10 gene, rs1205 of the CRP gene, and rs375947 of the IL12RB gene can be an important link in the pathogenesis of rheumatic heart disease and can later be used as biological markers for a personalized assessment of the disease risk.

show abstract

Section: ключевые моменты Key Messagesunclassified

Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Interleukin 1 and Interleukin 4 Genes Polymorphism Associated With Early and Preschool Age Children Sensitization to Streptococcus Pyogenes

Владимирович

Шабалдина

Рязанцев

et al. 2016

Russian Journal of Infection and Immunity

Self Cite

View full text Add to dashboard Cite

Адрес для переписки:Шабалдин Андрей Владимирович 650002, Россия, Кемерово, Сосновый бульвар, 6, ФГБНУ НИИ комплексных проблем сердечно-сосудистых заболеваний. Тел.: (3842) 39-64-29 (служебн.); 8 951 163-90-11 (моб.). E-mail: weit2007@ya.ru Contacts:Andrey V. Shabaldin 650002, Russian Federation, Kemerovo, Sosnovy blvd., 6, Scientific Research Institute for Complex Issues of Cardiovascular Diseases. Phone: +7 (3842) 39-64-29 (office); +7 951 163-90-11 (mobile). E-mail: weit2007@ya.ru Библиографическое описание: Шабалдин А.В., Шабалдина Е.В., Рязанцев С.В., Симбирцев А.С. Полиморфизм генов семейства интерлейкина 1 и интерлейкина 4 при сенсибилизации детей раннего и дошкольного возраста к Streptococcus pyogenes // Инфекция и иммунитет. 2016. Т. 6, № 1. С. 45-54. doi: 10.15789/2220-7619-2016-1-45-54 Citation: Shabaldin A.V., Shabaldina E.V., Ryazantsev S.V., Simbirtsev A.S. Interleukin 1 and interleukin 4 genes polymorphism associated with early and preschool age children sensitization to Streptococcus pyogenes // Russian Journal of Infection and Immunity = Infektsiya i immunitet, 2016, vol. 6, no. 1, pp. 45-54. doi: 10.15789/2220-7619-2016-1-45 Резюме. Введение. Инфицирование Streptococcus pyogenes и сенсибилизация к его антигенам является небла-гоприятным фактором в отношении индукции ревматической патологии. Поиск генетических предикторов ревматической патологии в целом и сенсибилизации к S. pyogenes в частности является актуальной пробле-мой современной медицины. Цель: изучение ассоциативных связей между полиморфизмами генов семейства интерлейкина 1 и интерлейкина 4 и развитием сенсибилизации к антигенам S. pyogenes у детей раннего и до-школьного возраста. Материалы и методы. Проведено обследование 771 ребенка, в возрастном интервале 2-6 лет, проходивших лечение по поводу рецидивирующих острых респираторных инфекций у врачей ал-лерголога-иммунолога и оториноларинголога. Всем детям проводили исследование антител к S. pyogenes с по-мощью твердофазного иммуноферментного анализа на к оммерческих наборах ООО «Иммунотекс» (г. Став-рополь, Россия). Детей, имеющих иммунный ответ по IgG типу к S. pyogenes, относили к основной группе (n = 306), а не имеющих его -к контрольной группе (n = 465 (+3953, С→T)*C,C / IL1Ra (VNTR, intron 2, 89 bp)*2r,4r / IL4 (VNTR intron 3, 70 bp)*2r,2r (OR = 46,15); IL1B (+3953, С→T)*T,T / I-1Ra (VNTR, intron 2, 89 bp)*4r,4r / IL4 (VNTR 46Инфекция и иммунитет А.В. Шабалдин и др. (OR = 7,23 Abstract. Background. Streptococcus pyogenes infection and sensitization to its antigens is considered to be an unfavorable factor for the induction of rheumatic pathology. The search for genetic predictors of rheumatic diseases in general, and sensitization to S. pyogenes, in particular, is of high relevance in modern medicine. Objective. To study the associations between interleukin 1 and interleukin 4 gene polymorphisms and the development of sensitization to antigens of S. pyogenes in toddlers and preschool children. Materials and methods. 771 children aged 2-6 years with recurrent acute respiratory...

show abstract

Biological Prostheses for Cardiovascular Surgery – A Half-Century History and Development Prospects

Kudryavtseva,

Ovcharenko,

Klyshnikov

et al. 2024

Kompleks. probl. serdečno-sosud. zabol.

View full text Add to dashboard Cite

HighlightsSurgical correction of cardiovascular deformities is inextricably linked with the use of prostheses. The development and clinical testing of biological prostheses has been conducted under the guidance of the Member of Russian Academy of Sciences Leonid Barbarash at the Kuzbass Cardiology Center for more than 50 years. The uniqueness of the developed products lies in the use of a new biological tissue preservative – ethylene glycol diglycidyl ether, and an integrated approach involving the development and manufacture of products, study of long-term replacement outcome, causes of prosthetic dysfunction and genetic aspects of the use of bioprostheses in patients. AbstractThis article highlights the main achievements in the development of biological prostheses for cardiovascular surgery under the leadership of the Member of Russian Academy of Sciences L.S. Barbarash since the 1980s. Throughout this period, Leonid Barbarash and his team have developed and mass-produced various designs of bioprosthetic heart valves and tissue preservation methods, arterial grafts, and patches. The article presents the results of developing next-generation vascular biodegradable grafts capable of complete remodeling and stimulating endothelialization after the implantation into the vascular bed. Moreover, we conducted a series of genetic studies evaluating the significance of gene polymorphisms of various pathogenetic pathways involved in the pathological calcification of native heart valves and their prostheses.

show abstract

FREQUENCY DISTRIBUTION OF INTRONIC POLYMORPHISMS OF IL1-raVNTR AND IL-4VNTR IN RHEUMATIC MITRAL VALVE DISEASE IN CAUCASIAN POPULATION OF SIBERIA

Cited by 3 publications

References 17 publications

Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease

Polymorphism of inflammatory system genes in the pathogenesis of rheumatic heart disease

Interleukin 1 and Interleukin 4 Genes Polymorphism Associated With Early and Preschool Age Children Sensitization to Streptococcus Pyogenes

Biological Prostheses for Cardiovascular Surgery – A Half-Century History and Development Prospects

Contact Info

Product

Resources

About