2021
DOI: 10.1101/2021.11.12.468369
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Frequency modulated timer regulates mammalian hibernation

Abstract: Mammalian hibernators decrease basal metabolism and body temperature (Tb) to minimize energy expenditure in harsh seasons. During hibernation, Tb drops to low temperature (<10 °C) and remains constant for days, known as deep torpor. Spontaneous interbout arousals interrupt torpor bouts, when Tb recovers to euthermic state ∼37 °C. Torpor-interbout arousal event repeats during hibernation. Little is known about mechanisms governing Tb fluctuation during hibernation. Here, we analyzed Tb fluctuation across Syr… Show more

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