Frequency of Different Abnormal Histopathologies in Perimenopausal Females With Abnormal Uterine Bleeding

Abstract

Objectives: To determine the frequency of diff erent histopathologies in perimenopausal femaleswith abnormal uterine bleeding.Materials and Methods: This descriptive cross sectional Study was carried out at the in the department of obstetrics and Gynecology Lady reading hospital from 21st September 2022 to 21st March 2023. Informed consent was taken. Detailed history of patients presenting with complaints of Abnormal uterine bleeding was taken and systemic examination done. Preoperative investigations were done. Those patients meeting the inclusion criteria underwent dilatation and curettage (DNC) under general anesthesia. Endometrial biopsy sample was collected and sent for histopathological evaluation by pathology department of lady Reading Hospital.Results: The most common clinical presentation was represented by irregular vaginal bleeding in 48.6% patients followed by heavy menstrual bleeding in 34% cases and intermenstrual bleeding in 16.9% cases.The predominant histopathological pattern was Secretory endometrium (29.5%) followed by disordered proliferative (19.7%), chronic endometritis (19.1%), endometrial polyp(14.8%), simple endometrial hyperplasia (7.7%), endometrial carcinoma (5.5%), atrophic endometrium (3.8%).Conclusion: The intended study concludes that the most common histopathological pattern of endometrium in patients with AUB is secretory endometrium regardless of age, parity and ethnicity. Careful screening can detect cancer of endometrium in its early stage favoring excellent prognosis.These conditions can be managed medically thereby avoiding surgery and its associated risks.