Frequency of Mutations in Brca1 and Brca2 Genes in Women with Breast Cancer in Córdoba, Argentina

Bella, Santiago; Llugdar, José; Bistoni, Marta Biagi; P, Pellicioni; Lerda, Daniel; Labrador, Jorge; Cruz, G. Fernández; Martins, Carlos

doi:10.20431/2455-6009.0101003

ARC Journal of Cancer Science

2015

DOI: 10.20431/2455-6009.0101003

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Frequency of Mutations in Brca1 and Brca2 Genes in Women with Breast Cancer in Córdoba, Argentina

Santiago Bella¹,

José Llugdar²,

Marta Biagi Bistoni³

et al.

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2022

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La utilidad del análisis BRCA 1 y 2

Lerda¹,

Labrador²,

Illescas³

2022

RevOnco

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Las mujeres con síndrome hereditario de cáncer de mama y de ovario representan un grupo único de pacientes, con riesgo de desarrollar cáncer de mama y ovario, entre otros tumores, a edades tempranas. Este síndrome se asocia a mutaciones de la línea germinal en los genes BRCA1 y BRCA2 y otros genes relacionados con las vías de reparación del ADN. La evidencia emergente indica que estos procesos están alterados por numerosos mecanismos, tanto en cánceres hereditarios como en esporádicos. En conjunto, los tumores con características de aquellos con el síndrome BRCA, que no presentan dicha mutación, se denominan "BRCAness”. Los mecanismos moleculares que subyacen a estas alteraciones pueden tener importantes implicancias pronósticas, terapéuticas y para el asesoramiento genético de estas pacientes.

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La utilidad del análisis BRCA 1 y 2

Lerda¹,

Labrador²,

Illescas³

2022

RevOnco

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show abstract

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Frequency of Mutations in Brca1 and Brca2 Genes in Women with Breast Cancer in Córdoba, Argentina

Cited by 1 publication

References 12 publications

La utilidad del análisis BRCA 1 y 2

La utilidad del análisis BRCA 1 y 2

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