Frequent Premature Ventricular Contraction and Non-Sustained Ventricular Tachycardia After the SARS-CoV-2 Vaccination in Patient With Implantable Cardioverter Defibrillator Due to Acquired Long-QT Syndrome

Aiba, Takeshi; Ishibashi, Keiichiro; Hattori, Katsuji; Wada, Mitsuru; Ueda, Nobuhiko; Miyazaki, Yuichiro; Wakamiya, Akinori; Yamagata, Kenichiro; Inoue, Yuko; Miyamoto, Koji; Nagase, Satoshi; Kusano, Kengo

doi:10.1253/circj.cj-21-0515

Cited by 8 publications

(6 citation statements)

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“…Rare cases of cardiac arrhythmias post-COVID-19 vaccination were reported in one case report and four RCTs of the Sputnik V, Oxford-AstraZeneca, Johnson and Johnson and Moderna vaccine. [ 40 43 44 ] A 46-year-old female had a background of implantable cardioverter defibrillator (ICD) for torsades de pointes following the delivery of her child at the age of 40. [ 44 ] She had occasional palpitations due to premature ventricular contractions (PVCs) but was previously free from faintness and torsades de pointes for six years.…”

Section: Resultsmentioning

confidence: 99%

“…[ 40 43 44 ] A 46-year-old female had a background of implantable cardioverter defibrillator (ICD) for torsades de pointes following the delivery of her child at the age of 40. [ 44 ] She had occasional palpitations due to premature ventricular contractions (PVCs) but was previously free from faintness and torsades de pointes for six years. She started to experience frequent palpitations due to frequent PVCs one day after the second dose of Pfizer-BioNTech vaccine, and had NSVT and torsades de pointes recorded by the ICD five days post-vaccination.…”

Section: Resultsmentioning

confidence: 99%

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A review of COVID-19 vaccination and the reported cardiac manifestations

Ho¹,

Sia²,

Ngiam³

et al. 2021

Singapore Medical Journal

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In Singapore, 9.03 million doses of the mRNA COVID-19 vaccines by Pfizer-BioNTech and Moderna have been administered, and 4.46 million people are fully vaccinated. An additional 87,000 people have been vaccinated with vaccines in World Health Organization’s Emergency Use Listing. The aim of this review is to explore the reported cardiac adverse events associated with different types of COVID-19 vaccines. 42 studies that reported cardiac side effects after COVID-19 vaccination were included in this study. Reported COVID-19 vaccine-associated cardiac adverse events were mainly myocarditis and pericarditis, most commonly seen in adolescent and young adult male individuals after mRNA vaccination. Reports of other events such as acute myocardial infarction, arrhythmia and stress cardiomyopathy were rare. Outcomes of post-vaccine myocarditis and pericarditis were good. Given the good vaccine efficacy and the high number of cases of infection, hospitalisation and death that could potentially be prevented, COVID-19 vaccine remains of overall benefit, based on the current available data.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A review of COVID-19 vaccination and the reported cardiac manifestations

Ho¹,

Sia²,

Ngiam³

et al. 2021

Singapore Medical Journal

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“…We experienced several patients complaining of palpitations or worsening of palpitations and arrhythmic events after mRNA COVID vaccination in our clinical practice. The review of the literature for post-vaccine heart rhythm disorders yielded several cases of heart rhythm disorders after mRNA COVID vaccination [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ] ( Table 1 ). Interestingly the COVID vaccine was the only one that was been found to be related to this side effect.…”

Section: Data From the Literature And Vigilance Databasesmentioning

confidence: 99%

Arrhythmias after COVID-19 Vaccination: Have We Left All Stones Unturned?

Cocco

Leibundgut

Pelliccia

et al. 2023

IJMS

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SARS-CoV-2 vaccination offered the opportunity to emerge from the pandemic and, thereby, worldwide health, social, and economic disasters. However, in addition to efficacy, safety is an important issue for any vaccine. The mRNA-based vaccine platform is considered to be safe, but side effects are being reported more frequently as more and more people around the world become treated. Myopericarditis is the major, but not the only cardiovascular complication of this vaccine; hence it is important not to underestimate other side effects. We report a case series of patients affected by cardiac arrhythmias post-mRNA vaccine from our clinical practice and the literature. Reviewing the official vigilance database, we found that heart rhythm disorders after COVID vaccination are not uncommon and deserve more clinical and scientific attention. Since the COVID vaccine is the only vaccination related to this side effect, questions arose about whether these vaccines could affect heart conduction. Although the risk–benefit ratio is clearly in favor of vaccination, heart rhythm disorders are not a negligible issue, and there are red flags in the literature about the risk of post-vaccination malignant arrhythmias in some predisposed patients. In light of these findings, we reviewed the potential molecular pathways for the COVID vaccine to impact cardiac electrophysiology and cause heart rhythm disorders.

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“…A total of 100 case reports or case series which reported cardiac complications after COVID-19 vaccination were included 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , …”

Section: Resultsmentioning

confidence: 99%