Frequent retinoic acid receptor alpha (Rar‐α) gene rearrangements and no point mutations of N‐Ras gene in fifteen cases of acute promyelocytic leukemia

Arranz, Eva; Santón, Almudena; Robledo, Mercedes; Sánchez-Fayos, J; Benı́tez, Javier

doi:10.1002/ajh.2830460228

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study suggests that NRAS mutations are rare in AMLs with t(8;21) or inv(l6). Several groups have previously shown that RAS mutations are infrequent in acute promyelocytic leukaemia with t(15;17) (6,21,22). Thus, it seems that AMLs with these characteristic and specific chromosomal abnormalities generally arise and progress without the involvement of NRAS mutations.…”

Section: Discussionmentioning

confidence: 99%

NRAS mutations are rare in acute myeloid leukaemias with t(8;21) or inv(16)

Panagopoulos

Åman

Johansson

et al. 1996

European J of Haematology

View full text Add to dashboard Cite

Using PCR and direct sequence methodology, 19 haematologic malignancies with trisomy 8, 18 with t(8;21)(q22;q22) and 8 with inv(16)(p13q22) were screened for NRAS mutations. Of the 45 samples analyzed, 4 (9%) had a mutation; both wild‐type and mutated alleles were observed in these 4 cases. Three of the mutations (involving codons 12 and 13) were found in the trisomy 8 group and 1 (codon 61) among the inv(16) samples. No specific clinical similarities were found in the 3 patients with + 8 and NRAS mutation. By analyzing two sequential samples from the patient with inv(16) and NRAS mutation, it was shown that the mutation had occurred after the inversion. Since no NRAS mutations were detected among the t(8;21) samples and only 1 was found in the inv(16) group, we conclude that acute myeloid leukaemias with t(8;21) or inv(16) generally arise and progress without the involvement of NRAS mutations.

show abstract

Section: Discussionmentioning

confidence: 99%