Freshly Thawed Cryobanked Human Neural Stem Cells Engraft within Endogenous Neurogenic Niches and Restore Cognitive Function after Chronic Traumatic Brain Injury

Badner, Anna; Reinhardt, Emily K.; Nguyen, Theodore V.; Midani, Nicole; Marshall, Andrew T.; Lepe, Cherie; Echeverria, Karla; Lepe, Javier; Torrecampo, Vincent; Bertan, Sara H; Tran, Serinee H.; Anderson, Aileen J.; Cummings, Brian J.

doi:10.1089/neu.2021.0045

Cited by 12 publications

(6 citation statements)

References 55 publications

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Section: Neurotrophins Promote the Survival Proliferation And Differe...mentioning

confidence: 99%

“…Transplantation of NSCs can serve as a viable approach to supplement the lost nerve cells in the damaged environment, alleviate neuroinflammation as well as glial hyperplasia reaction, and improve demyelination and axonal lesion, ultimately leading to recovery of neurological function. 87 In the research of Badner et al., 88 human NSCs were transplanted into mouse after TBI. Three months later, an increase in ipsilateral host hippocampus CA neuron survival, contralateral DG volume, and DG neural progenitor morphology and a decrease in neuroinflammation were identified.…”

Section: Interaction Between Neurotrophins and Neural Stem Cellsmentioning

confidence: 99%

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Neurotrophins and neural stem cells in posttraumatic brain injury repair

Guo,

Liu,

Wang

et al. 2023

Anim Models and Exp Med

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Traumatic brain injury (TBI) is the main cause of disability, mental health disorder, and even death, with its incidence and social costs rising steadily. Although different treatment strategies have been developed and tested to mitigate neurological decline, a definitive cure for these conditions remains elusive. Studies have revealed that various neurotrophins represented by the brain‐derived neurotrophic factor are the key regulators of neuroinflammation, apoptosis, blood–brain barrier permeability, neurite regeneration, and memory function. These factors are instrumental in alleviating neuroinflammation and promoting neuroregeneration. In addition, neural stem cells (NSC) contribute to nerve repair through inherent neuroprotective and immunomodulatory properties, the release of neurotrophins, the activation of endogenous NSCs, and intercellular signaling. Notably, innovative research proposals are emerging to combine BDNF and NSCs, enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after TBI. In this review, we summarize the mechanism of neurotrophins in promoting neurogenesis and restoring neural function after TBI, comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI, and investigate their interaction with NSCs. This endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI, thereby promoting the progress of TBI therapeutics.

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Section: Neurotrophins Promote the Survival Proliferation And Differe...mentioning

confidence: 99%

Section: Interaction Between Neurotrophins and Neural Stem Cellsmentioning

confidence: 99%

Neurotrophins and neural stem cells in posttraumatic brain injury repair

Guo,

Liu,

Wang

et al. 2023

Anim Models and Exp Med

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“…The transplanted cells increased host neuronal survival, reduced neuroinflammation, and improved cognitive functions. 53 …”

Section: Cell Transplantation In Cns Traumamentioning

confidence: 99%

Stem Cell Therapies for Central Nervous System Trauma: The 4 Ws—What, When, Where, and Why

Sundström

2022

Stem Cells Translational Medicine

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Traumatic injury of the central nervous system (CNS) is a worldwide health problem affecting millions of people. Trauma of the CNS, that is, traumatic brain injury (TBI) and spinal cord injury (SCI), lead to massive and progressive cell loss and axonal degeneration, usually with very limited regeneration. At present, there are no treatments to protect injured CNS tissue or to replace the lost tissue. Stem cells are a cell type that by definition can self-renew and give rise to multiple cell lineages. In recent years, therapies using stem and progenitor cells have shown promising effects in experimental CNS trauma, particularly in the acute-subacute stage, but also in chronic injuries. However, the therapeutic mechanisms by which transplanted cells achieve the structural and/or functional improvements are often not clear. Stem cell therapies for CNS trauma can be categorized into 2 main concepts, transplantation of exogenous neural stem cells and neural progenitor cells and recruitment of endogenous stem and progenitor cells. In this review, focusing on the advances during the last decade, we will discuss the major cell therapies, the pros and cons of these 2 concepts for TBI and SCI, and the treatment strategies we believe will be successful.

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“…Neural stem cells (NSCs) have a self-renewal ability and can differentiate into mature neurons [9,10]. Studies on the effectiveness of NSCs in treating TBI in rodents have shown that transplanted NSCs can survive and differentiate into neurons and then partially replace the damaged neurons, resulting in improved motor function after TBI, that a study in TBI rat models showed that NSCs are capable of surviving engraftment and differentiating into neurons which, in turn, correlate with improvements in neurological recovery [11][12][13][14]. Additionally, a study in mice also showed that the transplantation of NSCs can potentially repair and integrate neurons and glial cells at the injury site [15].…”

Section: Introductionmentioning

confidence: 99%

Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons

Liu,

Shi,

Huang

et al. 2024

IJMS

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Cortical traumatic brain injury (TBI) is a major cause of cognitive impairment accompanied by motor and behavioral deficits, and there is no effective treatment strategy in the clinic. Cell transplantation is a promising therapeutic strategy, and it is necessary to verify the survival and differentiation of cells after transplantation in large animal models like rhesus monkeys. In this study, we transplanted neural stem cells (NSCs) and simultaneously injected basic fibroblast growth factor/epidermal growth factor (bFGF/EGF) into the cortex (visual and sensory cortices) of rhesus monkeys with superficial TBI. The results showed that the transplanted NSCs did not enter the cerebrospinal fluid (CSF) and were confined to the transplantation site for at least one year. The transplanted NSCs differentiated into mature neurons that formed synaptic connections with host neurons, but glial scar formation between the graft and the host tissue did not occur. This study is the first to explore the repairing effect of transplanting NSCs into the superficial cerebral cortex of rhesus monkeys after TBI, and the results show the ability of NSCs to survive long-term and differentiate into neurons, demonstrating the potential of NSC transplantation for cortical TBI.

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Freshly Thawed Cryobanked Human Neural Stem Cells Engraft within Endogenous Neurogenic Niches and Restore Cognitive Function after Chronic Traumatic Brain Injury

Cited by 12 publications

References 55 publications

Neurotrophins and neural stem cells in posttraumatic brain injury repair

Neurotrophins and neural stem cells in posttraumatic brain injury repair

Stem Cell Therapies for Central Nervous System Trauma: The 4 Ws—What, When, Where, and Why

Neural Stem Cells Transplanted into Rhesus Monkey Cortical Traumatic Brain Injury Can Survive and Differentiate into Neurons

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