FRET-based ratiometric fluorescent probe for Cu 2+ with a new indolizine fluorophore

Zheng, Xiufen; Ji, Ruixue; Cao, Xiaoqun; Ge, Yanqing

doi:10.1016/j.aca.2017.04.048

Cited by 77 publications

(18 citation statements)

References 29 publications

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“…Compound 2 was obtained from commercial suppliers, and compound 3, 4, 5 and 6 were synthesized by the composited methods. 37,38 Synthesis of 7. A stirred solution of compound 5 (0.60 g, 1.50 mmol), compound 6 (0.68 g, 1.50 mmol) and NaH (0.07 g, 3.00 mmol) in anhydrous CH 3 CN (30 mL) was reuxed for 8 h under argon atmosphere.…”

Section: Synthesismentioning

confidence: 99%

A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

et al. 2019

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Section: Synthesismentioning

confidence: 99%

A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

et al. 2019

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“…Furthermore, the detection limit for Cu 2+ was estimated to be 22.8 nM with the ratio of signal‐to‐noise of 3. The performances of the proposed ratiometric fluorescence sensor based on ZIF‐8@rhodamine‐B nanocomposites were compared with some other Cu 2+ sensors in Table . The resulting sensor showed some superiority which might be owing to the uniform nanostructures of ZIF‐8@rhodamine‐B nanocomposites and the ratiometric method.…”

Section: Resultsmentioning

confidence: 99%

“…The fluorescence probes have important effect for fluorescence sensors . Organic probes and nanomaterial probes are the two main fluorescence probes used to date. Unfortunately, the use of organic probes is constrained because of their unavoidable disadvantages including the tedious synthetic process, biotoxicity, poor aqueous solubility and stability, etc.…”

Section: Introductionmentioning

confidence: 99%

Ratiometric fluorescent detection of Cu²⁺ based on dual‐emission ZIF‐8@rhodamine‐B nanocomposites

et al. 2019

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Zeolitic imidazolate framework-8 (ZIF-8) loading rhodamine-B (ZIF-8@rhodamine-B) nanocomposites was proposed and used as ratiometric fluorescent sensor to detect copper(II) ion (Cu 2+ ). Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, nitrogen adsorption/desorption isotherms and fluorescence emission spectroscopy were employed to characterize the ZIF-8@rhodamine-B nanocomposites. The results showed the rhodamine-B was successfully assembled on ZIF-8 based on the π-π interaction and the hydrogen bond between the nitrogen atom of ZIF-8 and -COOH of rhodamine-B. The as-obtained ZIF-8@rhodamine-B nanocomposites were octahedron with size about 150-200 nm, had good water dispersion, and exhibited the characteristic fluorescence emission of ZIF-8 at 335 nm and rhodamine-B at 575 nm. The Cu 2+ could quench fluorescence of ZIF-8 rather than rhodamine-B. The ZIF-8 not only acted as the template to assemble rhodamine-B, but also was employed as the signal fluorescence together with the fluorescence of rhodamine-B as the reference to construct a novel ratiometric fluorescent sensor to detect Cu 2+ . The resulted ZIF-8@rhodamine-B nanocomposite fluorescence probe showed good linear range (68.4 nM to 125 μM) with a low detection limit (22.8 nM) for Cu 2+ combined with good sensitivity and selectivity. The work also provides a better way to design ratiometric fluorescent sensors from ZIF-8 and other fluorescent molecules. KEYWORDSCu 2 + , ratiometric fluorescent sensor, rhodamine-B, zeolitic imidazolate framework-8 biotoxicity, poor aqueous solubility and stability, etc. Nanomaterial fluorescent probes, especially the metal-organic frameworks (MOFs) or zeolitic imidazolate framework-8 (ZIF-8) based probes, are attracting more and more interest and are used for different applications due to their predictable pore sizes, considerable specific surface area, good encapsulation and hierarchical structures. [35][36][37][38][39] For example, carbon dots (CDs)@MOFs have been prepared to enhance fluorescence sensing. [40] A ratiometric type fluorescence sensor has two or more emission wavelengths, and the target content is usually quantified based on the relationship between the ratio of fluorescence intensities at two wavelengths and the concentration of the analyte. At the same time, this sensor mode enhances the dynamic response range by adjusting the change of intensity ratio, and establishes an internal standard to make it self-regulating, greatly weakening the effect some experimental conditions such as probe concentration, temperature, polarity, environmental pH, and stability. These experimental conditions are usually difficult to control in the experimental process. Moreover, as the concentration of analyte changes, the color of the ratio probe changes step-by-step, thereby enabling visual detection of the analyte, and semi-quantitative and qualitative analysis of the analyte can be achieved depending on the color of the ratio probe. [41,42] Therefore, the construction of rati...

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“…So far, many Cu 2+ fluorescent probes have attracted great concern because of their high sensitivity and selectivity [12][13][14][15][16][17][18][19][20][21][22][23] . However, most of the designed probes are only available for one-photon fluorescence microscopy (1PM) with short excitation wavelengths and suffering from background interference.…”

Section: Introductionmentioning

confidence: 99%

A reversible and highly selective two-photon fluorescent “on–off–on” probe for biological Cu²⁺ detection

et al. 2018

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A two-photon active probe for physiological copper (Cu2+) detection is expected to play an important role in monitoring biological metabolism. Herein, a novel Schiff base derivative (E)-2,2'-((4-((4-(diethylamino)-2-hydroxybenzylidene)amino)phenyl)azanediyl)bis(ethan-1-ol) (L) with remarkable two-photon activity was developed and synthetically investigated. L presents high selectivity and sensitivity for Cu2+ sensing in ethanol/HEPES buffer (v/v, 1 : 1), which is accompanied by the fluorescence switching "off" and subsequently "on" with the addition of EDTA. The mechanism for the detection of Cu2+ is further analyzed using 1H NMR titration, mass spectra and theoretical calculations. Furthermore, since the probe L possesses good photophysical properties, excellent biocompatibility and low cytotoxicity, it is successfully applied to track Cu2+ in the cellular endoplasmic reticulum by two-photon fluorescence imaging, showing its potential value for practical applications in biological systems.

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FRET-based ratiometric fluorescent probe for Cu 2+ with a new indolizine fluorophore

Cited by 77 publications

References 29 publications

A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

Ratiometric fluorescent detection of Cu²⁺ based on dual‐emission ZIF‐8@rhodamine‐B nanocomposites

A reversible and highly selective two-photon fluorescent “on–off–on” probe for biological Cu²⁺ detection

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FRET-based ratiometric fluorescent probe for Cu 2+ with a new indolizine fluorophore

Cited by 77 publications

References 29 publications

A ratiometric and colorimetric probe for detecting Hg2+ based on naphthalimide–rhodamine and its staining function in cell imaging

A ratiometric and colorimetric probe for detecting Hg2+ based on naphthalimide–rhodamine and its staining function in cell imaging

Ratiometric fluorescent detection of Cu2+ based on dual‐emission ZIF‐8@rhodamine‐B nanocomposites

A reversible and highly selective two-photon fluorescent “on–off–on” probe for biological Cu2+ detection

Contact Info

Product

Resources

About

A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

A ratiometric and colorimetric probe for detecting Hg²⁺ based on naphthalimide–rhodamine and its staining function in cell imaging

Ratiometric fluorescent detection of Cu²⁺ based on dual‐emission ZIF‐8@rhodamine‐B nanocomposites

A reversible and highly selective two-photon fluorescent “on–off–on” probe for biological Cu²⁺ detection