FRI0366 Primary respiratory disease in patients with systemic lupus erythematosus: data from the spanish rheumatology society lupus registry (RELESSER) cohort

Abstract

ObjectivesTo investigate the primary respiratory manifestations (PRM) in SLE.MethodsAll patients in the RELESSER cohort were retrospectively investigated for the presence of PRMResultsAt least one PRM was present in 11.3% (365/3215) of cases. The most common was pleurisy, occurring in 21.1% of patients, followed by ALP in 3.6%, PE in 2.9%, PPH 4%, DILD in 2%, DAH in 0.8%, and SLS in 0.8%.The variables associated with the presence of PPM are shown in the following table 1:Odds Ratio95% ConfidenceIntervalP Age1,031,02–1,040.000SLEDAI score1,031,00–1,070,02Raynaud phenomenon1,411,09–1,840,01Severe nephritis1,561,18–2,060002Secondary APS2,21,63–2,970.000Anti-RNP positivity1,321,00–1,750054Cardiac disease2,811,90–4,160000Vasculitis1,811,25–2,620002Hematologic abnormalities1,311,00–1,710048Neuropsychiatric manifestations1,491,11–2.020009Gastrointestinal involvement2,051,14–3,670016After adjusting for known confounders in the multivariable model, PPM remained a risk factor for diminished survival (HR: 3.13).ConclusionsPPM independently contributed to a decreased survival in SLEDisclosure of InterestNone declared