2014
DOI: 10.1136/annrheumdis-2014-eular.2202
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FRI0369 Uc-Mscs Inhibit the Differentiation and Proliferation of T Follicular Helper Cell in Rheumatoid Arthritis

Abstract: Objectives The aim of our study was to elucidate whether umbilical cord derived mesenchymal stem cell (UC-MSCs) had immunomodulatory effect on T follicular helper (Tfh) cell under rheumatoid arthritis (RA) background. Methods PBMCs that isolated from RA patients and healthy contorl (HC) were cocultured with UC-MSCs at a ratio of 100:1, 10:1 and 1:1 respectively through cell-to-cell contact or in a transwell system at a ratio of 1:10. After 3 days' coculture, PBMCs were collected and the frequency of CD4+CXCR… Show more

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