“…Angiotensin II (Ang II) induces the expression of pro-fibrotic factors such as connective tissue growth factor (CTGF; Ruperez et al, 2003;Esteban et al, 2004), and recent studies have revealed that there is an intracellular cross-talk between Ang II signaling and TGFβ signaling that cooperatively promotes fibrosis (Campbell and Katwa, 1997;Schultz Jel et al, 2002;Gao et al, 2009). Leukotrienes (LTs) not only induce fibroblast migration, proliferation, and matrix protein synthesis, but also promote fibrosis through the stimulation and activation of TGFβ (Shim et al, 2006).…”