Friend or foe?

Colangelo, Tommaso; Polcaro, Giovanna; Muccillo, Livio; D'Agostino, G; Rosato, Valeria; Ziccardi, Pamela; Lupo, Angelo; Mazzoccoli, Gianluigi; Sabatino, Lina; Colantuoni, Vittorio

doi:10.1016/j.bbcan.2016.11.001

Cited by 64 publications

(55 citation statements)

References 153 publications

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“…In this regard, an important role is played by cancer associated fibroblasts, found in the nearness in the developing and advancing cancer and able to promote tumor development and metastasis through secretion of chemokines. A bidirectional cross-talk between tumor cells and cancer associated fibroblasts drives discharge by cancer cells of factors augmenting the ability of the fibroblasts to secrete an assortment of tumor-promoting chemokines, which subsequently impact on the malignant behavior of tumor cells upholding their proliferation, migration, and invasiveness [ 33 ]. The chemokines secreted by cancer associated fibroblasts impinge on the tumor microenvironment as well, stimulating neoangiogenesis and in some instances an important presence of cancer-supporting macrophages in tumors [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

A primary tumor gene expression signature identifies a crucial role played by tumor stroma myofibroblasts in lymph node involvement in oral squamous cell carcinoma

et al. 2017

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Oral squamous cell carcinoma (OSCC) is the most common oral and pharyngeal cancer, and is responsible of approximately 3% of cancers in men and 2% in women in the Western World, with increasing incidence rates in developing countries. Early detection by screening is necessary to prevent fatal disease because early, curable lesions are rarely symptomatic. The overall 5-yr survival rate is approximately 50% when surgery, radiation, or both are employed as treatment options, but lymph node involvement greatly influences this estimate, by decreasing the survival rate by about 50%. Here, we aimed at finding genetic signatures associated with lymph node metastasis in OSCC patients. We addressed this issue by whole transcriptome analysis through microarray expression profiling of a set of OSSC specimens of patients without lymph node involvement (10 patients, mean age ± SD 61.2±13.8, male 7, female 3) and with lymph node involvement (11 patients, mean age ± SD 62.1±15.1, male 8, female 3). We evidenced a gene expression signature associated to muscle contraction-related genes in specimens obtained from OSCC patients with lymph node involvement. This gene signature suggests the presence of myofibroblasts in tumor stoma of patients with lymph node involvement and emphasizes the decisive role played by myofibroblasts probably through their secretome in determining OSCC invasiveness.

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Section: Discussionmentioning

confidence: 99%

A primary tumor gene expression signature identifies a crucial role played by tumor stroma myofibroblasts in lymph node involvement in oral squamous cell carcinoma

et al. 2017

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“…The tumor microenvironment is known to play an important role in tumor progression, metastasis, and resistance to therapy [99, 100]. Mesenchymal stem cells are recruited to the tumor microenvironment where they have the capacity to modify the growth and metastatic potential of the cancer cells [88-89, 99, 101–104].…”

Section: Mesenchymal Stem Cells: Characterization and Functional Pmentioning

confidence: 99%

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

Vignais

Caicedo

Brondello

et al. 2017

Stem Cells International

152

163

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Intercellular communications play a major role in tissue homeostasis and responses to external cues. Novel structures for this communication have recently been described. These tunneling nanotubes (TNTs) consist of thin-extended membrane protrusions that connect cells together. TNTs allow the cell-to-cell transfer of various cellular components, including proteins, RNAs, viruses, and organelles, such as mitochondria. Mesenchymal stem cells (MSCs) are both naturally present and recruited to many different tissues where their interaction with resident cells via secreted factors has been largely documented. Their immunosuppressive and repairing capacities constitute the basis for many current clinical trials. MSCs recruited to the tumor microenvironment also play an important role in tumor progression and resistance to therapy. MSCs are now the focus of intense scrutiny due to their capacity to form TNTs and transfer mitochondria to target cells, either in normal physiological or in pathological conditions, leading to changes in cell energy metabolism and functions, as described in this review.

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“…but is rarely used in existing literature. Recent studies suggest that MFAP5 expression may vary between subtypes 23,29,67,68.…”

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confidence: 99%

In search of definitions: Cancer‐associated fibroblasts and their markers

Nurmik

Ullmann

Rodriguez

et al. 2019

Intl Journal of Cancer

497

428

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The tumor microenvironment has been identified as one of the driving factors of tumor progression and invasion. Inside this microenvironment, cancer‐associated fibroblasts (CAFs), a type of perpetually activated fibroblasts, have been implicated to have a strong tumor‐modulating effect and play a key role in areas such as drug resistance. Identification of CAFs has typically been carried based on the expression of various “CAF markers”, such as fibroblast activation protein alpha (FAP) and alpha smooth muscle actin (αSMA), which separates them from the larger pool of fibroblasts present in the body. However, as outlined in this Review, the expression of various commonly used fibroblast markers is extremely heterogeneous and varies strongly between different CAF subpopulations. As such, novel selection methods based on cellular function, as well as further characterizing research, are vital for the standardization of CAF identification in order to improve the cross‐applicability of different research studies in the field. The aim of this review is to give a thorough overview of the commonly used fibroblast markers in the field and their various strengths and, more importantly, their weaknesses, as well as to highlight potential future avenues for CAF identification and targeting.

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Friend or foe?

Cited by 64 publications

References 153 publications

A primary tumor gene expression signature identifies a crucial role played by tumor stroma myofibroblasts in lymph node involvement in oral squamous cell carcinoma

A primary tumor gene expression signature identifies a crucial role played by tumor stroma myofibroblasts in lymph node involvement in oral squamous cell carcinoma

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

In search of definitions: Cancer‐associated fibroblasts and their markers

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