Friendly fire: recognition of self by the innate immune system

Hornung, Veit; Gaidt, Moritz M

doi:10.1016/j.coi.2024.102457

Current Opinion in Immunology

2024

DOI: 10.1016/j.coi.2024.102457

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Friendly fire: recognition of self by the innate immune system

Veit Hornung,

Moritz M Gaidt

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2024

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Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives

Rizzi,

Li Pomi,

Inchingolo

et al. 2024

Biomedicines

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Background: In the world, approximately 1% of the population suffers from chronic spontaneous urticaria (CSU), burdening patients’ quality of life and challenging clinicians in terms of treatment. Recent scientific evidence has unveiled the potential role of a family of molecules known as “alarmins” in the pathogenesis of CSU. Methods: Papers focusing on the potential pathogenetic role of alarmins in CSU with diagnostic (as biomarkers) and therapeutic implications, in English and published in PubMed, Scopus, Web of Science, as well as clinical studies registered in ClinicalTrials.gov and the EudraCT Public website, were reviewed. Results: The epithelial-derived alarmins thymic stromal lymphopoietin and IL-33 could be suitable diagnostic and prognostic biomarkers and possible therapeutic targets in CSU. The evidence on the role of non-epithelial-derived alarmins (heat shock proteins, S-100 proteins, eosinophil-derived neurotoxin, β-defensins, and acid uric to high-density lipoproteins ratio) is more heterogeneous and complex. Conclusions: More homogeneous studies on large cohorts, preferably supported by data from international registries, will be able to elucidate the intriguing and complex pathogenetic world of CSU.

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Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives

Rizzi,

Li Pomi,

Inchingolo

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Friendly fire: recognition of self by the innate immune system

Cited by 1 publication

References 73 publications

Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives

Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives

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