From bench to bedside: Platelet biomimetic nanoparticles as a promising carriers for personalized drug delivery

Safdar, Ammara; Wang, Peina; Muhaymin, Abdul; Nie, Guangjun; Li, Suping

doi:10.1016/j.jconrel.2024.07.013

Journal of Controlled Release

2024

DOI: 10.1016/j.jconrel.2024.07.013

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From bench to bedside: Platelet biomimetic nanoparticles as a promising carriers for personalized drug delivery

Ammara Safdar,

Peina Wang,

Abdul Muhaymin

et al.

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2024

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Cited by 3 publications

References 185 publications

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Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Cai,

Qiu,

Chi‐Shing Cho

et al. 2024

MedComm

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Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potential of mRNA in RNA therapeutics. Within the RNA family, there is another unique type known as circRNA. This single‐stranded closed‐loop RNA molecule offers notable advantages over mRNA, including enhanced stability and prolonged protein expression, which may significantly impact therapeutic strategies. Furthermore, circRNA plays a pivotal role in the pathogenesis of various diseases, such as cancers, autoimmune disorders, and cardiovascular diseases, making it a promising clinical intervention target. Despite these benefits, the application of circRNA in clinical settings remains underexplored. This review provides a comprehensive overview of the current state of synthetic circRNA therapeutics, focusing on its synthesis, optimization, delivery, and diverse applications. It also addresses the challenges impeding the advancement of circRNA therapeutics from bench to bedside. By summarizing these aspects, the review aims to equip researchers with insights into the ongoing developments and future directions in circRNA therapeutics. Highlighting both the progress and the existing gaps in circRNA research, this review offers valuable perspectives for advancing the field and guiding future investigations.

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Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Cai,

Qiu,

Chi‐Shing Cho

et al. 2024

MedComm

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Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors

Wu,

Chen,

Wang

et al. 2024

Chemical Engineering Journal

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Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

Perini,

Matos,

de Oliveira

et al. 2024

Beilstein J. Nanotechnol.

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Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in the treatment of various complex human diseases. This strategy enhances drug delivery by leveraging the innate properties of cellular components, thereby improving biocompatibility and targeting specificity. Biomimetic nanocarriers demonstrate significant advancements in drug delivery systems against cancer therapy, Alzheimer's disease, autoimmune diseases, and viral infections such as COVID-19. Here, we address the therapeutic applications of biomimetic nanocarriers and their promising strategy for personalized medicine.

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From bench to bedside: Platelet biomimetic nanoparticles as a promising carriers for personalized drug delivery

Cited by 3 publications

References 185 publications

Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

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