From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity

Li, Xiaxia; Ma, Lina

doi:10.1016/j.arr.2023.102175

Cited by 10 publications

(2 citation statements)

References 96 publications

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“…Li et al did not find any correlation in older adults between inflammation markers and functional status. The authors suggest a probable role of multiple factors influence rather than one single marker [ 41 ]. However, in the Northern Manhattan Study of younger adults, higher serum CRP levels related to higher baseline disability, even when adjusting for baseline covariates, stroke, and myocardial infarction occurring during follow up [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity

Kupisz-Urbanska,

Marcinowska-Suchowierska,

Jankowski

2024

Nutrients

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Background: The relationship between functional and nutritional status in the geriatric population remains an issue of debate and there is a gap in the knowledge regarding this field in long-lived individuals. Aim: The main aim of this study was to assess the association between selected blood parameters of nutritional status and functional status in extreme longevity. Methods: The inclusion criteria were centenarians above 100 years of age who were examined at their homes, and blood samples were collected. The study group consisted of 170 individuals (25 men and 145 women, median age 100.75 years [100.29–101.58]). Results: Total protein and albumin serum concentration was significantly lower in long-lived individuals with severe functional decline compared to individuals with preserved functional status, p = 0.000001 and p = 0.0000, respectively. Iron serum level was significantly higher in the group with preserved functional status, p = 0.04. Preserved functional status was positively correlated with total protein serum concentration (p = 0.000), albumin concentration (p = 0.000), and iron serum level (p = 0.029). A negative correlation was stated between c-reactive protein (CRP) and functional status (p = 0.032). Univariable logistic regression analysis showed that the functional status of long-lived individuals depends on total protein (OR 2.89, CI 95% [1.67–5.0]) and albumin concentrations (OR 2.34, CI 95% [1.39–3.92]). Multivariable backward stepwise logistic regression analysis showed that a total protein concentration was the only variable independently related to the preserved functional status (OR 3.2, 95% Cl [1.8–5.67]). Conclusions: In long-lived individuals, the total serum protein and albumin levels are lower in centenarians with severe functional decline, and they correlate with functional status. Total protein serum concentration is the only factor independently related to the preserved functional status in extreme longevity.

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Section: Discussionmentioning

confidence: 99%

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity

Kupisz-Urbanska,

Marcinowska-Suchowierska,

Jankowski

2024

Nutrients

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“…Inflammation, a natural and complex biological response, is crucial in defending against infection [ 1 , 2 ]. Yet, chronic or uncontrolled inflammation can be harmful, contributing to the development of various diseases [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases

Shin,

Park,

Shin

et al. 2024

IJMS

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Over the past century, molecular biology’s focus has transitioned from proteins to DNA, and now to RNA. Once considered merely a genetic information carrier, RNA is now recognized as both a vital element in early cellular life and a regulator in complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles in gene expression regulation and signal transduction by inducing epigenetic changes or interacting with various proteins and RNAs. These interactions exhibit a range of functions in various cell types, including macrophages. Notably, some macrophage lncRNAs influence the activation of NF-κB, a crucial transcription factor governing immune and inflammatory responses. Macrophage NF-κB is instrumental in the progression of various pathological conditions including sepsis, atherosclerosis, cancer, autoimmune disorders, and hypersensitivity. It orchestrates gene expression related to immune responses, inflammation, cell survival, and proliferation. Consequently, its malfunction is a key contributor to the onset and development of these diseases. This review aims to summarize the function of lncRNAs in regulating NF-κB activity in macrophage activation and inflammation, with a particular emphasis on their relevance to human diseases and their potential as therapeutic targets. The insights gained from studies on macrophage lncRNAs, as discussed in this review, could provide valuable knowledge for the development of treatments for various pathological conditions involving macrophages.

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Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong

Rajasuriar,

Hisham,

Lim

et al. 2024

J Int AIDS Soc.

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IntroductionWHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. Assessments of IC may be useful to address the evolving, non‐HV care needs of ageing people with HIV (PWH). However, to date, its utility within the context of HIV has not been assessed.MethodsParticipants included 200 PWH attending out‐patient care (2021−2023) in Universiti Malaya Medical Centre, Malaysia and 101 community controls aged 35 years and above. The ICOPE framework was adapted to derive aggregate IC scores (ranging 0–6) encompassing the five domains of cognition, sensory (hearing and vision), mobility, mood and vitality. Multivariable analyses were used to explore the association of IC scores in PWH with multiple health outcomes including frailty, difficulties performing instrumental activities of daily living (IADL) and inflammatory markers. Area under the receiver operator characteristic (AUC‐ROC) was calculated to predict frailty and IADL deficits in the current cohort and an independent cohort of 275 PWH from Hong Kong (HK).ResultsMedian (interquartile range, IQR) age among PWH and controls were 50 (42−56) and 50 (39−59) years, respectively. There were more males among PWH (83% vs. 56%, p<0.001). All PWH received antiretroviral therapy (ART) for a median duration of 11 (8−14) years. Aggregate IC scores were lower in PWH but not significantly different compared to controls, (5.4 vs. 5.6, p = 0.093) and PWH performed significantly worse than controls only in the cognitive domain. Aggregate IC scores in PWH was independently associated with frailty (OR 0.17 95% CI 0.07−0.42, p<0.001), IADL deficits (OR 0.25 95% CI 0.14−0.46, p<0.001) and all other patient‐reported outcomes assessed. Aggregate IC scores correlated with IL‐6 but not sCD14 and sCD163 levels. IC scores performed well in identifying PWH with frailty (AUC‐ROC ≥ 0.80) in the HK and Malaysian cohorts but more modestly (AUC‐ROC ≥ 0.64) for IADL deficits.ConclusionsIC is a good composite measure to monitor non‐HIV, age‐associated physical and social vulnerabilities in PWH on ART and should complement disease‐based monitoring in routine HIV care. Assessments of IC should be validated in larger, longitudinal cohorts of PWH from diverse settings.

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From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity

Cited by 10 publications

References 96 publications

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity

Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases

Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong

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