From Cotton Candy to Diagnosis and Monitoring of Atherosclerosis: Contrast-Enhanced Ultrasound Quantification of Intraplaque Neovascularization

Fazelpour, Siavosh; Mulvagh, Sharon L.

doi:10.1016/j.echo.2021.08.018

Cited by 2 publications

(1 citation statement)

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“…Carotid artery examination is invaluable for atherosclerosis screening. Intraplaque neovascularization (IPN) is one of the characteristics of vulnerable plaques [ 11 ], and evidence suggests that contrast-enhanced ultrasonography (CEUS) can be successfully employed to assess and quantify carotid IPN [ 12 , 13 ], which has led to its widespread use. Studies have shown that carotid IPN assessed by CEUS can predict cardiovascular and cerebrovascular events [ 14 - 16 ].…”

Section: Introductionmentioning

confidence: 99%

Remnant Cholesterol and Carotid Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasonography in Patients With Ischemic Stroke

Song,

Dang,

Feng

et al. 2024

Cardiol Res

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Background We investigated the relationship between remnant cholesterol and carotid intraplaque neovascularization (IPN) assessed by contrast-enhanced ultrasonography (CEUS) in patients with ischemic stroke. Methods This was a single-center study. Remnant cholesterol is calculated as total cholesterol minus low-density lipoprotein cholesterol (LDL-C) minus high-density lipoprotein cholesterol (HDL-C). All patients underwent CEUS. IPN is graded according to the presence and location of microbubbles within each plaque. Results The cohort included 110 patients with ischemic stroke. Patients with an IPN grading of 2 had higher triglyceride (TG), non-HDL-C, and remnant cholesterol concentrations than those with an IPN grading of < 2 (TG: 1.45 ± 0.69 vs. 0.96 ± 0.24 mmol/L, P < 0.001; non-HDL-C: 2.63 ± 0.85 vs. 2.31 ± 0.64 mmol/L, P = 0.037; remnant cholesterol: 0.57 ± 0.23 vs. 0.44 ± 0.07 mmol/L, P < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for remnant cholesterol was 27.728 (2.714 - 283.253) for an IPN grading of 2 in the subset of patients with an optimal LDL-C concentration. Conclusions The remnant cholesterol concentration is significantly associated with carotid IPN on CEUS in patients with ischemic stroke with an optimal LDL-C concentration. Remnant cholesterol may be an important indicator of risk stratification in patients with ischemic stroke.

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Section: Introductionmentioning

confidence: 99%

Remnant Cholesterol and Carotid Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasonography in Patients With Ischemic Stroke

Song,

Dang,

Feng

et al. 2024

Cardiol Res

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Contrast-enhanced ultrasound evaluation of plaque vulnerability and the relationship between peripheral blood leukocytes

Qiao,

Wang,

et al. 2024

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OBJECTIVE: To evaluate plaque vulnerability by carotid contrast-enhanced ultrasound (CEUS) and to analyze the correlation between plaque vulnerability and peripheral blood leukocyte classification. MATERIALS AND METHODS: 135 patients with carotid plaque were examined by contrast-enhanced ultrasound. Plaque vulnerability was assessed by semiquantitative visual classification. Baseline clinical data and peripheral leukocyte classification were collected. Ordered logistic regression was used to analyze the correlation between plaque neovascularization grade and peripheral leukocyte classification count. RESULTS: There were significant differences in leukocyte, monocyte, neutrophil, mean platelet volume, lymphocyte, and neutrophil counts between different neovascular plaque grades and peripheral blood (P < 0.05). Correlation analysis showed that leukocyte, monocyte, and neutrophil counts were significantly positively correlated. CONCLUSION: The increase in plaque neovascularization is associated with an increase in circulating leukocytes, monocytes, and neutrophils. Therefore, CEUS combined with peripheral blood leukocytes may serve as an early warning of plaque vulnerability and provide a theoretical basis for clinical treatment.

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From Cotton Candy to Diagnosis and Monitoring of Atherosclerosis: Contrast-Enhanced Ultrasound Quantification of Intraplaque Neovascularization

Cited by 2 publications

References 20 publications

Remnant Cholesterol and Carotid Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasonography in Patients With Ischemic Stroke

Remnant Cholesterol and Carotid Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasonography in Patients With Ischemic Stroke

Contrast-enhanced ultrasound evaluation of plaque vulnerability and the relationship between peripheral blood leukocytes

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