From formulation of acrylamide-based hydrogels to their optimization for drug release using response surface methodology

Sabbagh, Farzaneh; Muhamad, Ida Idayu; Nazari, Zahra; Mobini, Peyman; Taraghdari, Sara Baghban

doi:10.1016/j.msec.2018.06.022

Cited by 41 publications

(18 citation statements)

References 22 publications

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“…Response surface methodology (RSM) is a combination of statistical and mathematical techniques which applied for modeling and data analysis in different fields of engineering. RSM can reduce the number of experimental trials, model the complex multivariate processes, and reveal the interaction among reaction factors for optimization 16–18 . Serdar Aydın 19 determined the best content of fly ash and silica fume in alkali‐activated slag mortars by RSM.…”

Section: Introductionmentioning

confidence: 99%

Application of response surface methodology to optimize alkali‐activated slag mortar with limestone powder and glass powder

Zhang

Zhai

2020

Structural Concrete

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An experimental and statistical investigation is carried out to analyze the influences of three variables (limestone powder, glass powder, and alkali content) on performance of alkali activated slag mortar. Response surface methodology (RSM) was used to model all measured responses like 28‐day flexural and compressive strength, water absorption, and dry shrinkage. Analysis of variance showed that all developed models were statistically significant. The interaction between the corresponding variables was analyzed using three‐dimensional response surface plots that were drawn using developed regression models. Optimization was performed using desirability approach of the RSM with an objective to maximize 28‐day flexural and compressive strength while minimizing water absorption and drying shrinkage. The optimum values of limestone powder, glass powder, and alkali content with highest desirability of 0.706 are 15.80, 17.02, and 6.71%, respectively. The predicted combination was validated by confirmatory tests and the error in prediction was found to be within 3.5%.

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Section: Introductionmentioning

confidence: 99%

Application of response surface methodology to optimize alkali‐activated slag mortar with limestone powder and glass powder

Zhang

Zhai

2020

Structural Concrete

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“…This concentration was also achieved by using buffer as the release medium but at 35°C instead, while the values at 37 and 39°C are a little higher; this indicates that, at the same temperature, a higher release of acetaminophen in HPC/PAAm is obtained by using PBS (pH 7.38) instead of water (pH 7) as the release medium. Therefore, as reported in [4,5], the pH value has an influence on the release of the drug.…”

Section: Release Testsmentioning

confidence: 84%

“…Currently, numerous scientific researches on hydrogels as Drug Delivery Systems have been reported in [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is a particularly interesting hydrogel because it is biodegradable.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

Díaz-Guerrero

Castillo-Miranda

Castro-Guerrero

et al. 2019

International Journal of Polymer Science

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Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures. The release can be activated under certain stimuli, such as temperature and pH. In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported. The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen. The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution. In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR). Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel. Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon. A unique mathematical model was obtained by MSR. This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R 2 and adjusted R 2 and to simulate the drug release at times beyond the end of the experiment. High values of R 2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data. This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C.

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“…Then the swelling polymer was lifted from the water till no longer dripped, the weight was W2. The water absorbency or named as swell ratio in DI water (Q) was calculated according to the following Equation (1) [41] :…”

Section: Water Absorption Propertiesmentioning

confidence: 99%

Ammonium nitrogen adsorption from aqueous solution by poly(sodium acrylate)s: Effect on the amount of crosslinker and initiator

Li¹,

Huang²,

Tsai³

et al. 2020

J of Applied Polymer Sci

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In this work, we discuss the ammonium nitrogen adsorption and reusability from aqueous solution by using poly(sodium acrylate) (PANa) hydrogels (Polymers 1–6) under different amount of crosslinker and initiator. The PANa hydrogels were synthesized from the neutralized acrylic acid (AA) monomer via free radical thermal polymerization by using ammonium persulfate (APS) as an initiator and N,N′‐methylene‐bisacrylamide (MBA) as a crosslinker. These polymers exhibited glass transition temperatures (Tg) of 68–88°C and Td values (5% weight loss temperature) in the range of 190–221°C under nitrogen atmosphere. The PANa hydrogels had swollen ratios ranging from 387 to 4,063%, related to the crosslinking density. The final equilibrium adsorption capacity of the polymers was in the range of 20–39 ppm with an initial ammonium nitrogen concentration of 100 ppm. Among them, Polymer 3 without MBA crosslinker displayed the highest swollen characteristic along with the most efficient adsorption capacity. In comparison, the as‐prepared high crosslinking density hydrogels showed relative lower adsorption capability but higher reusability. The polymer composition in this work determines the ability to absorb and desorb ammonium nitrogen compound.

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From formulation of acrylamide-based hydrogels to their optimization for drug release using response surface methodology

Cited by 41 publications

References 22 publications

Application of response surface methodology to optimize alkali‐activated slag mortar with limestone powder and glass powder

Application of response surface methodology to optimize alkali‐activated slag mortar with limestone powder and glass powder

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

Ammonium nitrogen adsorption from aqueous solution by poly(sodium acrylate)s: Effect on the amount of crosslinker and initiator

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