Handbook of Pharmaceutical Biotechnology 2006
DOI: 10.1002/9780470117118.ch1a
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From Gene to Product: The Advantage of Integrative Biotechnology

Abstract: PRODUCTION ORGANISMS AND EXPRESSION SYSTEMSDesign and development of all microbial production processes start with the selection of appropriate organisms, strains, and expression systems enabling high yields and high quality of a desired product with defi ned pharmacological properties. Industrially Established Recombinant Expression SystemsIndustrially established expressions systems for production of the marketed compounds are, besides inclusion, body-forming Escherichia coli strains, the yeast Saccharomyces… Show more

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Cited by 6 publications
(2 citation statements)
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References 195 publications
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“…Animal tissue and/or cell culture has important implications in biotechnology in the production of vaccines, pharmaceuticals and antibodies (used for diagnosis and treatment) [1][2][3]. Moreover the culture of some animal cells can produce a correctly processed protein that can be secreted into the culture medium, which greatly facilitates the purification process [4].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Animal tissue and/or cell culture has important implications in biotechnology in the production of vaccines, pharmaceuticals and antibodies (used for diagnosis and treatment) [1][2][3]. Moreover the culture of some animal cells can produce a correctly processed protein that can be secreted into the culture medium, which greatly facilitates the purification process [4].…”
Section: Introductionmentioning
confidence: 99%
“…Industrially well-known expressions systems have become progressively more popular for the production of biopharmaceuticals, using bodyforming Escherichia coli strains, the yeast Saccharomyces cerevisiae and mammalian cells like Chinese hamster ovary cells (CHO) and baby hamster kidney (BHK) cells [1]. Animal tissue and/or cell culture has important implications in biotechnology in the production of vaccines, pharmaceuticals and antibodies (used for diagnosis and treatment) [1][2][3].…”
Section: Introductionmentioning
confidence: 99%