From general toxicology to DNA disruption: A safety assessment of Plinia cauliflora (Mart.) Kausel

Palozi, Rhanany Alan Calloi; Lorençone, Bethânia Rosa; Guarnier, Lucas Pires; Romão, Paulo Vitor Moreira; Marques, Aline Aparecida Macedo; Hulsmeyer, Ana Paula Cestari Rodrigues; Lourenço, Emerson Luiz Botelho; Tolouei, Sara Emília Lima; Silva, Gabriela Neubert da; Curi, Tatiana Zauer; Passoni, Marcella Tapias; Dalsenter, Paulo Roberto; Araújo, Flávio Henrique Souza de; Oesterreich, Silvia Aparecida; Souza, Roosevelt Isaías Carvalho; Santos, Ariany Carvalho dos; Castilho, Pamella Fukuda de; Oliveira, Kelly Mari Pires de; Nocchi, Samara Requena; Silva, Denise Brentan; Gasparotto, Arquimedes

doi:10.1016/j.jep.2020.112916

Cited by 8 publications

(2 citation statements)

References 57 publications

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“…(1) Acute Toxicity. Te acute toxicity assay was evaluated according to protocols from Palozi et al [12]. Twelve female Wistar rats were equally randomized into two experimental groups.…”

Section: Safety Evaluationmentioning

confidence: 99%

Cardioprotective Effects of Solidago microglossa DC. in Nicotine‐Treated Hypertensive Rats

Lopes,

Marques,

Moreno

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Solidago microglossa DC. (Asteraceae), “arnica brasileira,” is a Brazilian species popularly used to treat hypertension or renal ailments. This study investigated the cardioprotective effects of standardized S. microglossa extract (EESM) in nicotine-treated spontaneously hypertensive rats (SHRs). Moreover, the molecular mechanisms involved in the cardiovascular effects were also investigated. The acute toxicity was evaluated in female Wistar rats. Afterwards, six-month-old male spontaneously hypertensive rats received the EESM (14, 28, and 56 mg/kg), hydrochlorothiazide (25 mg/kg), and vehicle (filtered water; 0.1 mL/100 g) once daily for 28 days. All treatments were associated with 1.8 mg/kg of nicotine. At the end of the experimental period, the renal function, electrocardiographic profile, blood pressure, ventricular function, biochemical parameter, and mesenteric vascular bed reactivity were evaluated. Relative organ weights and cardiac morphometry were also investigated. Nicotine treatment in 6-month-old SHRs induced a significant reduction in renal function, with reduced urinary volume and lower renal elimination of sodium and creatinine. In addition, serum markers of the redox state and blood pressure levels remained significantly elevated, contributing to changes in vascular reactivity and left ventricular hypertrophy associated with reduced ventricular function. After 28 days of treatment, we found that the highest dose of EESM could mitigate all renal and cardiovascular changes developed by the nicotine-treated hypertensive rats. This study presented EESM as a possible cardioprotective drug that prevents cardiovascular dysfunctions in nicotine-treated hypertensive rats. Our data suggest EESM as a potential adjuvant therapy when cardioprotective effects are required.

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“…(1) Acute Toxicity. Te acute toxicity assay was evaluated according to protocols from Palozi et al [12]. Twelve female Wistar rats were equally randomized into two experimental groups.…”

Section: Safety Evaluationmentioning

confidence: 99%

Cardioprotective Effects of Solidago microglossa DC. in Nicotine‐Treated Hypertensive Rats

Lopes,

Marques,

Moreno

et al. 2023

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…Acute toxicity was assessed according to the methodologies described previously [28]. Female Wistar rats (n = 5/group) were randomly distributed into two experimental groups, weighed, and treated orally with a single dose of AEPB (2000 mg/kg) or vehicle (filtered water, 0.2 mL/100 g).…”

Section: Acute Toxicitymentioning

confidence: 99%

The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats

et al. 2022

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Blutaparon portulacoides is a Brazilian plant species that is widely used in folk medicine. The present study investigated the role of an aqueous extract of B. portulacoides against hypertension in spontaneously hypertensive rats. The aqueous extract of B. portulacoides was obtained from the whole plant. Its chemical profile was analyzed by ultraperformance liquid chromatography-tandem mass spectrometry. The acute toxicity of the aqueous extract of B. portulacoides was evaluated in female Wistar rats. Male 6-month-old spontaneously hypertensive rats then received the aqueous extract of B. portulacoides (30, 100, and 300 mg/kg), hydrochlorothiazide (25 mg/kg), or vehicle once daily for 28 days. On days 1, 14, and 28, the diuretic effects of the aqueous extract of B. portulacoides were evaluated. The role of prostaglandins and the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway in the diuretic activity of the aqueous extract of B. portulacoides was also investigated. At the end of the treatment, hepatic and renal biochemical markers, serum nitrotyrosine, malondialdehyde, nitrite, and aldosterone levels, and angiotensin-converting enzyme activity were measured. The electrocardiographic profile, blood pressure, and renal vascular reactivity were also assessed. The heart, kidneys, and liver were collected to determine relative organ weight, histopathology, and cardiac morphometry. Caffeic acid, ferulic acid, and several flavonoids were identified in the aqueous extract of B. portulacoides. No signs of toxicity were observed. Prolonged treatment with the aqueous extract of B. portulacoides (300 mg/kg) induced significant diuretic activity by activating the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway. These effects reduced blood pressure and oxidative stress and prevented renal vascular dysfunction and left ventricular hypertrophy that was induced by hypertension. Overall, the present data suggest that the aqueous extract of B. portulacoides has important diuretic and cardioprotective effects by activation of the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway.

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Copalic Acid: Occurrence, Chemistry, and Biological Activities

Medeiros

Durán

Lang

2021

Rev. Bras. Farmacogn.

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From general toxicology to DNA disruption: A safety assessment of Plinia cauliflora (Mart.) Kausel

Cited by 8 publications

References 57 publications

Cardioprotective Effects of Solidago microglossa DC. in Nicotine‐Treated Hypertensive Rats

Cardioprotective Effects of Solidago microglossa DC. in Nicotine‐Treated Hypertensive Rats

The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats

Copalic Acid: Occurrence, Chemistry, and Biological Activities

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