From Genes to Therapy in Autism Spectrum Disorder

Vorstman, Jacob; Freitag, Christine M.; Persico, Antonio M.

doi:10.3390/genes13081377

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…Management of these overlapping conditions requires self-knowledge by the patient, a supportive environment and appropriate interventions, often including medication [66][67][68][69]. The increasing knowledge of ASD at the molecular level over time will improve the accuracy of medication targeting [70,71]; meanwhile, clinicians need to be flexible in finding what works.…”

Section: Comorbidity % With Asd Referencesmentioning

confidence: 99%

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance

McCrossin¹

2023

Children

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It appears that up to 80% of females with autistic spectrum disorder (ASD) have not been diagnosed by the age of 18. This translates to a prevalence of about 5–6%, and if true, has serious implications for female mental health. One way of finding the true value is to use Bayes’ Theorem with a comorbid condition as a more easily recognizable flag. An obvious choice is anorexia nervosa (AN), but it transpires that the proportion of women with ASD who develop AN is unknown. This study uses published data in novel ways to provide two methods of estimating a range for this variable, and gives a median value of 8.3% for AN in ASD and, with four other methods, a median prevalence of 6% for female ASD. The clinical implications of the diagnosis and management of ASD and its comorbidities are discussed and, as an example, a solution is provided for the rate of ASD in symptomatic generalized joint hypermobility. It is probable that one in six women with a mental health condition is autistic.

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Section: Comorbidity % With Asd Referencesmentioning

confidence: 99%

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance

McCrossin¹

2023

Children

View full text Add to dashboard Cite

show abstract

“…Management of these overlapping conditions requires self-knowledge by the patient, a supportive environment and appropriate interventions often including medication [62,63,64,65]. The increasing knowledge of ASD at the molecular level over time will improve the accuracy of medication targeting [66,67] but meanwhile clinicians need to be flexible in finding what works.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance.

McCrossin¹

2022

Preprint

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It appears that up to 80% of females with autistic spectrum disorder (ASD) have not been diagnosed by 18 years of age. This translates to a prevalence of about 5-6%, and if true has serious implications for female mental health. One way of finding the true value is to use Bayes’ Theorem with a comorbid condition as a more easily recognizable flag. An obvious choice is anorexia nervosa (AN), but it transpires that the proportion of women with ASD who develop AN is unknown. This study uses published data in novel ways to provide two methods of estimating a range for this variable, and gives a median value of 8.3% for AN in ASD and with four other methods a median prevalence of 6% for female ASD. The clinical implications for diagnosis and management of ASD and comorbidities are discussed and a solution is provided for the rate of ASD in generalized joint hypermobility.

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Contemplating syndromic autism

Vorstman

Scherer

2023

Genetics in Medicine

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From Genes to Therapy in Autism Spectrum Disorder

Abstract: In recent years, findings from genetic and other biological studies are starting to reveal the role of various molecular mechanisms that contribute to the etiology of ASD [...]

Cited by 4 publications

References 60 publications

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance.

Contemplating syndromic autism

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