From heterogeneity to plasticity in adipose tissues: Site-specific differences

Prunet-Marcassus, Bénédicte; Cousin, Béatrice; Caton, David; Meynier, André; Pénicaud, Luc; Casteilla, Louis

doi:10.1016/j.yexcr.2005.11.021

Cited by 245 publications

(190 citation statements)

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“…Stem cells isolated from each type differ in number and differentiation potential. Generally, adult stem cells from WAT exhibit a higher differentiation potential, are more abundant, and grow faster than cells isolated from BAT [30,31]. There are differences in the ASC population, even when the cells are isolated from different anatomical regions of the same type of adipose tissue [32,33].…”

Section: The Differentiation Potential Of Adipose-derived Stem/stromamentioning

confidence: 99%

Stem cells from adipose tissue

Witkowska-Zimny

Walenko

2011

Cellular and Molecular Biology Letters

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This is a review of the growing scientific interest in the developmental plasticity and therapeutic potential of stromal cells isolated from adipose tissue. Adipose-derived stem/stromal cells (ASCs) are multipotent somatic stem cells that are abundant in fat tissue. It has been shown that ASCs can differentiate into several lineages, including adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. At the same time, adipose tissue can be harvested by a minimally invasive procedure, which makes it a promising source of adult stem cells. Therefore, it is believed that ASCs may become an alternative to the currently available adult stem cells (e.g. bone marrow stromal cells) for potential use in regenerative medicine. In this review, we present the basic information about the field of adipose-derived stem cells and their potential use in various applications.

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Section: The Differentiation Potential Of Adipose-derived Stem/stromamentioning

confidence: 99%

Stem cells from adipose tissue

Witkowska-Zimny

Walenko

2011

Cellular and Molecular Biology Letters

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“…17,20,21 Comparative analysis of MSC, bone marrow stromal cells (BMSC), ADSC, and umbilical cord stem cells (UCSC) showed that ADSC are not different in relation to morphology and immunologic phenotype in comparison with BMSC and UCSC. 10,15 . However, the frequency of ADSC in the adipose tissue is higher than that of BMSC [III] in the medullary stroma.…”

Section: Ved Stem Cellsmentioning

confidence: 99%

“…13 In mice, researchers noticed differences in cell composition and differentiation capacity of ADSC, based on anatomical regions. 15 Therefore, it appears that human adipose tissue is probably constituted by different subtypes of stem cells, based on the anatomical region. Nevertheless, more comparative studies about the nature of the cells and the potential of differentiation of ADSC isolated from adipose tissue of distinct anatomical regions are needed.…”

Section: Ved Stem Cellsmentioning

confidence: 99%

“…13 The stromal vascular fraction (SVF) of adipose tissue has been the focus of recent research on adipose-derived stem cells -ADSC. 9,11,14,15 Some studies indicate that this tissue compartment is a rich source of pluripotent cells [14][15][16] , although some scientists question the pluripotentiality of ADSC. 17 ADSC, however, share characteristics of ASC and their application in pharmacological and clinical studies, particularly in the search for treatment of degenerative diseases, has been considered.…”

Section: Introductionmentioning

confidence: 99%

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Células-tronco derivadas de tecido adiposo humano: desafios atuais e perspectivas clínicas

Yarak

Okamoto

2010

An. Bras. Dermatol.

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Adult or somatic stem cells hold great promise for tissue regeneration. Currently, one major scientific interest is focused on the basic biology and clinical application of mesenchymal stem cells. Adipose tissue-derived stem cells share similar characteristics with bone marrow mesenchymal stem cells, but have some advantages including harvesting through a less invasive surgical procedure. Moreover, adipose tissue-derived stem cells have the potential to differentiate into cells of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, as well as cells of non-mesodermal lineage, such as hepatocytes, pancreatic endocrine cells, neurons, cardiomyocytes, and vascular endothelial cells. There are, however, inconsistencies in the scientific literature regarding methods for harvesting adipose tissue and for isolating, characterizing and handling adipose tissue-derived stem cells. Future clinical applications of adipose tissue-derived stem cells rely on more defined and widespread methods for obtaining cells of clinical grade quality. In this review, current methods in adipose tissue-derived stem cell research are discussed with emphasis on strategies designed for future applications in regenerative medicine and possible challenges along the way. Key words: Adipocytes; Adipose tissue; Adult stem cells; Tissue therapy Resumo: As células-tronco adultas ou somáticas detêm grande promessa para a reparação e regeneração de tecidos. Atualmente, o interesse dos cientistas é contínuo na investigação da biologia de células-tronco mesenquimais, tanto em aspectos básicos, quanto no potencial de aplicações terapêuticas. As células-tronco adultas derivadas do estroma do tecido adiposo, em comparação com as células-tronco derivadas do estroma da medula óssea, apresentam como vantagem o método fácil de obtenção da fonte tecidual. As células-tronco adultas derivadas do estroma do tecido adiposo apresentam potencial para se diferenciarem em células de tecidos mesodérmicos, como os adipócitos, as cartilagens, os ossos e o músculo esquelético e não mesodérmicos, como os hepatócitos, as células pancreáticas endócrinas, os neurônios, os hepatóci-tos e as células endoteliais vasculares. Entretanto, os dados disponíveis na literatura científica sobre as características das células-tronco adultas derivadas do estroma do tecido adiposo e os procedimentos para sua obtenção e manipulação no laboratório são inconsistentes. É necessário o desenvolvimento de metodologias e procedimentos eficazes de isolamento dessas células para obtenção de células em quantidade e qualidade suficientes para aplicação terapêutica. Nesta revisão, são discutidos os métodos correntes de coleta de tecido adiposo, isolamento e caracterização de células-tronco adultas derivadas do estroma do tecido adiposo, com ênfase na futura aplicação em medicina regenerativa e nos possíveis desafios nesse recente campo da ciência.

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“…Plus récemment a été démontrée la pré-sence au sein du tissu adipeux de populations de cellules capables de se différencier ex vivo en divers types cellulaires, ostéo-blastes, chondroblastes, cellules endothé-liales et myocytes et, de manière encore plus inattendue, cardiomyocytes [2][3][4]. L'analyse phénotypique par cytométrie en flux de la SVF révèle la présence de multiples progéniteurs engagés dans différentes voies de différenciation [5]. Enfin, nous avons identifié de vraies cellules souches multipotentes dans des échantillons de SVF obtenus à partir de déchets opératoires de tissu adipeux de jeunes enfants.…”

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