Sustainability assessments considering the three dimensions environment, economy, and society are needed to evaluate manufacturing processes and products with regard to their sustainability performance. This chapter focuses on Life Cycle Sustainability Assessment (LCSA), which considers all three sustainability dimensions by combining the three methods Life Cycle Assessment (LCA), Life Cycle Costing (LCC), and Social Life Cycle Assessment (SLCA). Existing LCSA approaches as well as selected ongoing work are introduced, both regarding the individual approaches as well as the combined LCSA approach. This includes, for instance, the Tiered Approach. This approach facilitates the implementation of LCSA, for instance, within the manufacturing sector, by providing a category hierarchy and guiding practitioners through the various impact and cost categories proposed for the three methods. Furthermore, ongoing developments in LCC and SLCA are presented, such as the definition of first economic and social impact pathways (linking fair wage and level of education to social damage levels) for addressing the current challenges of missing impact pathways for economic and social aspects. In addition, the Sustainability Safeguard Star suggests a new scheme for addressing the inter-linkages between the three sustainability dimensions. These approaches foster the application and implementation of LCSA and thus contribute to developing sustainable processes and products.