From metabolism to behaviour – Multilevel effects of environmental methamphetamine concentrations on fish

Santos, Maria Eugenia Sancho; Horký, Pavel; Grabicová, Kateřina; Steinbach, Christoph; Hubená, Pavla; Šálková, Eva; Slavík, Ondřej; Grabic, Roman; Randák, Tomáš

doi:10.1016/j.scitotenv.2023.163167

Cited by 5 publications

(4 citation statements)

References 94 publications

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“…As an example, brown trout ( Salmo trutta m. fario ) that were exposed to 1 µg/L METH for 28 days showed reduced levels of metabolic rates. These changes were shown to be associated with the concentrations of METH and AMPH in the brain, as well as changes in brain metabolomics [ 101 ].…”

Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

“…Evidence has demonstrated that METH increases melatonin levels and activates associated pathways in the brains of brown trout [ 101 ]. This phenomenon may be attributed to melatonin’s antioxidant properties, including direct free radical scavenging and increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage and its capability to diminish the proinflammatory mediators, which serve to protect the nervous system and mitigate the detrimental effects of METH [ 108 , 109 ].…”

Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

“…METH exposure has been linked to significant behavioral alterations in fish. For instance, Sancho Santos et al (2023) observed that brown trout (Salmo trutta m. fario L.) exposed to environmentally relevant concentrations of METH (1 µg/L) for 28 days displayed reduced activity levels [101]. Similarly, Liao et al (2015) reported dose-dependent effects of METH on zebrafish, inducing hypolocomotion and affecting swimming metrics such as active time and average velocity.…”

Section: Behavior Disorders In Fish As the Frontline Response To Illi...mentioning

confidence: 99%

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Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Falfushynska,

Rychter,

Boshtova

et al. 2024

Pharmaceuticals

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The United Nations World Drug Report published in 2022 alarmed that the global market of illicit drugs is steadily expanding in space and scale. Substances of abuse are usually perceived in the light of threats to human health and public security, while the environmental aspects of their use and subsequent emissions usually remain less explored. However, as with other human activities, drug production, trade, and consumption of drugs may leave their environmental mark. Therefore, this paper aims to review the occurrence of illicit drugs in surface waters and their bioaccumulation and toxicity in fish. Illicit drugs of different groups, i.e., psychostimulants (methamphetamines/amphetamines, cocaine, and its metabolite benzoylecgonine) and depressants (opioids: morphine, heroin, methadone, fentanyl), can reach the aquatic environment through wastewater discharge as they are often not entirely removed during wastewater treatment processes, resulting in their subsequent circulation in nanomolar concentrations, potentially affecting aquatic biota, including fish. Exposure to such xenobiotics can induce oxidative stress and dysfunction to mitochondrial and lysosomal function, distort locomotion activity by regulating the dopaminergic and glutamatergic systems, increase the predation risk, instigate neurological disorders, disbalance neurotransmission, and produce histopathological alterations in the brain and liver tissues, similar to those described in mammals. Hence, this drugs-related multidimensional harm to fish should be thoroughly investigated in line with environmental protection policies before it is too late. At the same time, selected fish species (e.g., Danio rerio, zebrafish) can be employed as models to study toxic and binge-like effects of psychoactive, illicit compounds.

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Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

Section: Behavior Disorders In Fish As the Frontline Response To Illi...mentioning

confidence: 99%

See 1 more Smart Citation

Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Falfushynska,

Rychter,

Boshtova

et al. 2024

Pharmaceuticals

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“…The presence of METH in water environments might pose hazards to aquatic organisms and ecosystems. For example, research has indicated that the presence of METH in water interferes with the respiration, metabolism, and reproductive functions of aquatic organisms, leading to death and growth retardation [ 39 ]. The ecology-associated behaviors and processes of aquatic organisms (i.e., elegans) were disrupted by METH at low levels (50 ng/L), showing ecological system outcomes [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

The Exploration of Joint Toxicity and Associated Mechanisms of Primary Microplastics and Methamphetamine in Zebrafish Larvae

Wang,

Xu,

Yuan

et al. 2024

Toxics

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The co-existence of microplastics (MPs) and methamphetamine (METH) in aquatic ecosystems has been widely reported; however, the joint toxicity and associated mechanisms remain unclear. Here, zebrafish larvae were exposed individually or jointly to polystyrene (PS) and polyvinyl chloride (PVC) MPs (20 mg/L) and METH (1 and 5 mg/L) for 10 days. The mortality, behavioral functions, and histopathology of fish from different groups were determined. PS MPs posed a stronger lethal risk to fish than PVC MPs, while the addition of METH at 5 mg/L significantly increased mortality. Obvious deposition of MPs was observed in the larvae’s intestinal tract in the exposure groups. Meanwhile, treatment with MPs induced intestinal deposits and intestinal hydrops in the fish, and this effect was enhanced with the addition of METH. Furthermore, MPs significantly suppressed the locomotor activation of zebrafish larvae, showing extended immobility duration and lower velocity. METH stimulated the outcome of PS but had no effect on the fish exposed to PVC. However, combined exposure to MPs and METH significantly increased the turn angle, which declined in individual MP exposure groups. RNA sequencing and gene quantitative analysis demonstrated that exposure to PS MPs and METH activated the MAPK signaling pathway and the C-type lectin signaling pathway of fish, while joint exposure to PVC MPs and METH stimulated steroid hormone synthesis pathways and the C-type lectin signaling pathway in zebrafish, contributing to cellular apoptosis and immune responses. This study contributes to the understanding of the joint toxicity of microplastics and pharmaceuticals to zebrafish, highlighting the significance of mitigating microplastic pollution to preserve the health of aquatic organisms and human beings.

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