From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Zhou, Zhenjun; Long, Hui-Zhi; Cheng, Yan; Luo, Hongyu; Wen, Dan-Dan; Gao, Lichen

doi:10.3389/fmicb.2021.767931

Cited by 34 publications

(39 citation statements)

References 150 publications

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“…and Staphylococcus spp., based on the identification of the cultivable aerobic bacterial microbiota ( 17 ). Notably, inflammation is crucial for the progression of cervical cancer to cancer ( 53 , 54 ). A dysbiotic microbiome dominated by aerobic species can create an inflammatory environment that is favorable for tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Disturbances of Vaginal Microbiome Composition in Human Papillomavirus Infection and Cervical Carcinogenesis: A Qualitative Systematic Review

et al. 2022

Front. Oncol.

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BackgroundEmerging evidence has demonstrated a close association between perturbations in vaginal microbiota composition in women and human papillomavirus (HPV) infection, cervical lesions, and cervical cancer (Ca); however, these findings are highly heterogeneous and inconclusive.AimTo perform a comprehensive systematic review of the global disturbance in the vaginal microbiota, specifically in women with HPV-associated cervical diseases, and to further conduct within- and across-disease comparisons.MethodTwenty-two records were identified in a systematic literature search of PubMed, Web of Science, and Embase up to February 28, 2022. We extracted microbial changes at the community (alpha and beta diversity) and taxonomic (relative abundance) levels. Within- and across-disease findings on the relative abundance of taxonomic assignments were qualitatively synthesized.ResultsGenerally, significantly higher alpha diversity was observed for HPV infection, cervical lesions, and/or cancer patients than in controls, and significant differences within beta diversity were observed for the overall microbial composition across samples. In within-disease comparisons, the genera Gardnerella, Megasphaera, Prevotella, Peptostreptococcus, and Streptococcus showed the greatest abundances with HPV infection; Sneathia and Atopobium showed inconsistent abundance with HPV infection, and Staphylococcus was observed in Ca. Across diseases, we find increased levels of Streptococcus and varying levels of Gardnerella were shared across HPV infections, high-grade squamous intraepithelial lesions, and Ca, whereas Lactobacillus iners varied depending on the HPV-related disease subtype.ConclusionsThis systematic review reports that vaginal microbiome disturbances are correlated to the depletion of Lactobacillus, enrichment of anaerobes, and increased abundance of aerobic bacteria in HPV infection and related cervical diseases. Moreover, L. iners may exert either protective or pathogenic effects on different HPV-related diseases.

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Section: Discussionmentioning

confidence: 99%

Disturbances of Vaginal Microbiome Composition in Human Papillomavirus Infection and Cervical Carcinogenesis: A Qualitative Systematic Review

et al. 2022

Front. Oncol.

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“…Chronic stressors critically impact on the cytokines profile as compared with chronic stress hormonal signaling ( Chen et al., 2021 ). In particular, the expression of IL-1, IL-2, IL-6, INF-γ, TNF-α, TGFβ, EGF, VEGF, and other growth factors are relatively more associated with chronic conditions as compared to other cytokines ( Ho et al., 2021 ; Lu et al., 2021 ; Zhou et al., 2021 ). The reason behind this concept is that there are few cytokines, interleukins, and chemokines which have higher circulating levels as compared to other stress mediators, especially in asymptomatic individuals.…”

Section: Relationship Between Stress and Cytokine Profiles In Cervica...mentioning

confidence: 99%

“…IFN-α and IFN-β are the main cytokines expressed downstream to cause activation of the innate immune system. As well as the cytokines associated with an adaptive immune system, mainly including IL-6, IL-8, IL-12, IFN-α2, TNF-α and MIP1α, are also associated with the inflammatory responses in the cervix infections ( Zhou et al., 2021 ). These are produced upon activation of macrophages and dendritic cells, NK cells, and activated T cells.…”

Section: Relationship Between Stress and Cytokine Profiles In Cervica...mentioning

confidence: 99%

“…There is a diverse microbial spectrum in the body complementing a microbiome that contains a complex mutualistic host-microbial relationship which play crucial roles in the development and physiological function of the body including immune system modulation and inflammation ( Sims et al., 2021 ; Wu et al., 2021 ; Zhou et al., 2021 ). Cervical microbiota has identified a diversity of microbial species as possible modifiers of the cytokine profile of the cervical microenvironment, especially during increased stress conditions including physical, mental, and emotional stress ( Curty et al., 2020 ).…”

Section: Cervicovaginal Microbiome Profiles and Cervical Cancermentioning

confidence: 99%

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A systematic assessment of stress insomnia as the high-risk factor for cervical cancer and interplay of cervicovaginal microbiome

Rai

Nahar

Jat

et al. 2022

Front. Cell. Infect. Microbiol.

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Cervical cancer is a dreaded form of cancer in women, the fourth most common cancer, with around 0.3 million females suffering from this disease worldwide. Over the past several decades, global researches have focused on the mitigation of cervical lesions and cancers and have explored the impact of physiological and psychological stress and insomnia on cervical pathogenesis. Furthermore, disruption of the cervicovaginal microbiome profiles is identified as an added high-risk factor for the occurrence of cervical cancer. The physiological regulation of stress has an underlying mechanism controlled via hypothalamic pituitary adrenal (HPA) and sympatho-adrenal medullary (SAM) axes. Disruptions in these axes have been identified as the factors responsible for maintaining the homeostasis balance. Recent studies on microbiomes have offered novel ways to combat cervical cancer and cervix infection by exploring the interplay of the cervicovaginal microbiome. Moreover, the integration of various immune cells and microbiome diversity is known to act as an effective strategy to decipher the cervix biological activity. Cytokine profiling and the related immune competence, and physiological stress and insomnia impart to the regulatory networks underlying the mechanism which may be helpful in designing mitigation strategies. This review addressed the current progress in the research on cervical cancer, HPV infection, immune cell interaction, and physiological stress and insomnia with the cervicovaginal microbiome to decipher the disease occurrence and therapeutic management.

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“…In turn, acidifying of the vaginal ecosystem provides a protective barrier against viral and bacterial pathogens (4)(5)(6). After menopause, the lack of estrogen lead to a decrease in Lactobacillus and an increase in anaerobic bacteria in the vaginal flora (7). However, various other factors, including ethnicity, sexual activity, hygiene habits, lactation, and dietary factors can also affect the composition of the vaginal microbiota (1,(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Increased diversity of a cervical microbiome associates with cervical cancer

et al. 2022

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The cervical microbiome (CM) is a complex ecosystem that can change in response to gynecological cancers. We aimed to evaluate changes in the CM of patients who underwent chemoradiation (CRT) therapy for locally advanced cervical cancer. Before and after CRT, cervical swab samples were collected from 16 patients with squamous cell carcinoma of the cervix, and 30 healthy women. All samples were subjected to 16s rRNA-Seq analysis. In healthy premenopausal women the CM comprised mostly Lactobacillus (>90%); the CM community in samples from both pre- and postmenopausal pre-treatment cancer patients was heterogeneous, with a low proportion of Lactobacillus in younger cases. On the genus level, 27 and 11 taxa differentiated healthy controls from cancer patients in pre- and postmenopausal age groups, while 31 and 2 genera differentiated pre- and post-radiation samples and pre-radiation and the follow-up samples, respectively. Microbiome diversity was significantly higher in pre-treatment patients than in healthy controls. The results reveal significant alterations in the CM of cervical cancer patients relative to that in healthy controls; these changes were more striking after CRT. However, further research is needed to determine whether alteration of the CM offers new therapeutic options.

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From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Cited by 34 publications

References 150 publications

Disturbances of Vaginal Microbiome Composition in Human Papillomavirus Infection and Cervical Carcinogenesis: A Qualitative Systematic Review

Disturbances of Vaginal Microbiome Composition in Human Papillomavirus Infection and Cervical Carcinogenesis: A Qualitative Systematic Review

A systematic assessment of stress insomnia as the high-risk factor for cervical cancer and interplay of cervicovaginal microbiome

Increased diversity of a cervical microbiome associates with cervical cancer

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