From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River

Yamamoto, Fábio Iuji; Souza, A.T.C.; Paula, Vinícius de Carvalho Soares de; Beverari, Isabella; Garcia, Juan Ramón Esquivel; Padial, André Andian; Abessa, Denis Moledo de Souza

doi:10.1016/j.scitotenv.2022.157332

Cited by 11 publications

(5 citation statements)

References 67 publications

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“…Our results suggest that beyond the ore tailings released after the Fundão dam rupture, other contaminant sources could be contributing, at least locally, to the contamination by metals, corroborating the results of Yamamoto, Souza et al (2022). Moreover, our results confirmed the literature in indicating that despite the reduction of the concentrations of metals in the sediments, there is a persistence of levels above the federal limits or the regional backgrounds, at least for some elements such as As, Mn, Cd, and Al.…”

Section: Discussionsupporting

confidence: 92%

Spatial–temporal variations of metals and arsenic in sediments from the Doce River after the Fundão Dam rupture and their bioaccumulation in Corbicula fluminea

Pauly

Cruz

Trevizani

et al. 2023

Integr Envir Assess & Manag

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The rupture of the Fundão dam in Brazil released tons of mining tailings into the Doce River Basin (DRB). This investigation aimed to determine the bioaccumulation of metals in soft tissues of the bivalve Corbicula fluminea exposed to sediments collected in the DRB in four periods (just after, 1, 3, and 3.5 years after the dam rupture). In the exposure bioassays, the concentrations of Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn in sediments and bivalve soft tissues were quantified. The concentration of some elements (As, Cd, Mn, and Al) in sediments exceeded the federal limits or regional backgrounds at some sampling sites, but their concentrations tended to decrease over time. However, higher concentrations of many elements were detected in the winter of 2019. Several elements were detected in C. fluminea soft tissues, but the bioaccumulation factors were generally low or not related to those elements associated with the ore tailings, evidencing that the bioavailability of metals to bivalves, in laboratory conditions, was limited. Integr Environ Assess Manag 2023;00:1–12. © 2023 SETAC

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Section: Discussionsupporting

confidence: 92%

Spatial–temporal variations of metals and arsenic in sediments from the Doce River after the Fundão Dam rupture and their bioaccumulation in Corbicula fluminea

Pauly

Cruz

Trevizani

et al. 2023

Integr Envir Assess & Manag

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“…Our results may indicate improving conditions in the Rio Doce, because six months after the rupture, Vergilio et al (2021) observed water and sediment toxicity in tests with microalgae (R. subcapitata), D. similis, and Allium cepa; the authors did not observe toxicity to adults of Danio rerio. In another study, using elutriates from sediments collected in 2019, Yamamoto, Souza, et al (2022) detected adverse effects in embryos of Rhamdia quelen, which were associated with metals and organic compounds. Moreover, the results S11-S13), there were no associations, as corroborated in the multivariate analysis (Supporting Information: Tables S14-S16).…”

Section: Discussionmentioning

confidence: 98%

Has the Rio Doce “time bomb” been defused? Using a weight‐of‐evidence approach to determine sediment quality

Abessa

Burton

Cervi³

et al. 2023

Integr Envir Assess & Manag

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The Fundão mine tailings dam rupture of 2015, in the Rio Doce basin, Brazil, resulted in the deposition of tailings downstream of the dam. It has yet to be determined if metals associated with the tailings have contributed toxicity to organisms, burying a time bomb that could be ticking. Currently the data on toxicity to benthic and aquatic organisms have not been assessed sufficiently to allow an informed assessment using an approach based on weight‐of‐evidence. This study was conducted to ascertain if sediments at “hot spots” that received Fundão tailings reflected elevated concentrations of metals and if these concentrations were sufficient to result in toxicity to freshwater organisms. The lines‐of‐evidence considered included assessing metals concentrations in relation to sediment quality criteria, establishing biogeochemical characterizations, completing an evaluation of potential metal release upon resuspension to provide information on bioavailability, and identifying acute and chronic toxicity effects using sensitive native species for waters (water flea, Daphnia similis) and sediments (burrowing midge larvae, Chironomus sancticaroli). Only porewater concentrations of iron and manganese exceeded Brazilian surface water criteria, whereas most trace elements exhibited no enrichment or elevated environmental indexes. The concentrations of bioavailable metals were assessed to be low, and metal concentrations did not increase in the overlying water upon resuspension; rather, they decreased through time. Toxicity testing in resuspended waters and bulk sediments resulted in no acute or chronic toxicity to either benthic or aquatic species. The low metal bioavailability and absence of toxicity of the tailings‐enriched sediments was attributed to the strong binding and rapid removal of potentially toxic metal ions caused by oxyhydroxides and particles in the presence of iron‐rich particulates. The findings of these sediment hot‐spot studies indicate the Fundão dam release of tailings more than six years ago is not causing the current release of toxic concentrations of metals into the freshwaters of the Rio Doce. Integr Environ Assess Manag 2023;00:1–11. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

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“…For the analysis of amino acids in biological samples, fish embryos ( Rhamdia quelen ) were obtained in the Panama Fish Farm (Paulo Lopes, Brazil) in March 2021 using the same procedures for fish breeding as described by Yamamoto et al [ 26 ]. Amino acids and other metabolites were extracted from 7 pooled samples (approximately 50 mg of lyophilized embryos for each sample) according to the method proposed by Ortiz-Villanueva et al [ 27 ] and are fully detailed in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Linking MS1 and MS2 signals in positive and negative modes of LC-HRMS in untargeted metabolomics using the ROIMCR approach

Yamamoto,

Pérez-López,

Lopez-Antia

et al. 2023

Anal Bioanal Chem

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Data-independent acquisition (DIA) mode in liquid chromatography (LC) high-resolution mass spectrometry (HRMS) has emerged as a powerful strategy in untargeted metabolomics for detecting a broad range of metabolites. However, the use of this approach also represents a challenge in the analysis of the large datasets generated. The regions of interest (ROI) multivariate curve resolution (MCR) approach can help in the identification and characterization of unknown metabolites in their mixtures by linking their MS1 and MS2 DIA spectral signals. In this study, it is proposed for the first time the analysis of MS1 and MS2 DIA signals in positive and negative electrospray ionization modes simultaneously to increase the coverage of possible metabolites present in biological systems. In this work, this approach has been tested for the detection and identification of the amino acids present in a standard mixture solution and in fish embryo samples. The ROIMCR analysis allowed for the identification of all amino acids present in the analyzed mixtures in both positive and negative modes. The methodology allowed for the direct linking and correspondence between the MS signals in their different acquisition modes. Overall, this approach confirmed the advantages and possibilities of performing the proposed ROIMCR simultaneous analysis of mass spectrometry signals in their differing acquisition modes in untargeted metabolomics studies. Graphical Abstract

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From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River

Cited by 11 publications

References 67 publications

Spatial–temporal variations of metals and arsenic in sediments from the Doce River after the Fundão Dam rupture and their bioaccumulation in Corbicula fluminea

Spatial–temporal variations of metals and arsenic in sediments from the Doce River after the Fundão Dam rupture and their bioaccumulation in Corbicula fluminea

Has the Rio Doce “time bomb” been defused? Using a weight‐of‐evidence approach to determine sediment quality

Linking MS1 and MS2 signals in positive and negative modes of LC-HRMS in untargeted metabolomics using the ROIMCR approach

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