From Nature to Market: Examples of Natural Products that Became Drugs

Fátima, Ângelo de; Terra, Bruna Silva; Silva, Cleiton Moreira da; Silva, Daniel Leite da; Araújo, Débora P.; Neto, Leonardo da Silva; Aquino, Roney Anderson Nascimento de

doi:10.2174/1872208307666131220163108

Cited by 9 publications

(3 citation statements)

References 49 publications

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“…Benefits from of this kind of therapy are not unexpected, since natural products have always been an ample source of new medical compounds [80]. Due to its phytochemical composition, rose hip is an interesting therapeutic option for those disorders which involve oxidative stress and/or a pro-inflammatory status.…”

Section: Rose Hip and Diseasementioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

143

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Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.

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Section: Rose Hip and Diseasementioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

143

View full text Add to dashboard Cite

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“…Due to these secondary metabolites, the medicinal plants have great significance in the modern world. More than 30% of drugs in the modern world are derived from a plant source or derived from plant products ( de Fátima et al, 2014 , Patwardhan, 2005 , Rah et al, 2012 , Rah et al, 2015b ). These valuable secondary metabolites possess numerous pharmacological activities including antioxidant, antimicrobial, anti-depressant, anti-lipidemic, anti-inflammatory, antitumor and other biological activities which can be of immense significance in therapeutics against different medical ailments ( Alnuqaydan et al, 2020 , Iwara et al, 2014 , Ksouri et al, 2009 , Mubashir et al, 2017 , Nascimento et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of biological activities of different parts of halophytic plant Tamarix articulata (T. articulata) growing in Saudi Arabia

Alnuqaydan

Rah

2020

Saudi Journal of Biological Sciences

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Owing to extremely high salinity and harsh environmental conditions, T. articulata is one of the most abundant wild plants growing in the deserts of Saudi Arabia. Such plants may contain novel compounds to display promising biological activities. Here, in this study, we evaluate the biological activities of methanolic extracts of fresh leaves, dry leaves, stem, and roots of T. articulata. The antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and total phenolic and flavonoid content were determined using standard colorimetric methods. Whereas antimicrobial and ant-proliferative activities were determined by standard well-diffusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods, respectively. Our results demonstrate that all methanolic extracts of T. articulata showed antioxidant activity, however, the methanolic extract of dry leaves exhibits promising antioxidant effect with IC₅₀ value 49.08 ± 1.98, which was strongly supported by total phenolic (409.92 ± 6.03 mg GAE/g DW) and flavonoid (177.71 mg QE/g DW) content. Although, antimicrobial activity was also exhibited by all the methanolic extracts, however, methanolic extract of dry leaves exhibits promising antimicrobial activity in Gram-positive bacteria Staphylococcus epidemidis. Furthermore , MTT assay revealed that all methanolic extracts exhibit antiproliferative activity in MCF-7 (breast cancer) and RKO (colorectal cancer) cells with IC₅₀ values ranges from 219 ± 5.112 µg/ml to 253 ± 5.231 µg/ml and 220 ± 4.330 µg/ml to 325 ± 6.213 µg/ml, respectively. However, the most promising antiproliferative effect was displayed by methanolic extract of dry leaves with IC₅₀ values 219 ± 5.112 µg/ml and 220 ± 4.330 µg/ml, respectively . In summary, these findings provide evidence that T. articulata has promising biological activities and can be used for many pharmaceutical activities in the future.

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“…The diversity of chemical structure makes natural products very valuable to pharmaceutical industries and agricultural segments as well. Natural products from plants, in particular, have been a great source of inspiration for improving human and animal life quality as disease therapeutics and also for increasing food resources [31–36] .…”

Section: Introductionmentioning

confidence: 99%