From Plant Compounds to Botanicals and Back: A Current Snapshot

Durazzo, Alessandra; D’Addezio, Laura; Camilli, Emanuela; Piccinelli, Raffaela; Turrini, Aida; Marletta, Luisa; Marconi, Stefania; Lucarini, Massimo; Lisciani, Silvia; Gabrielli, Paolo; Gambelli, Loretta; Aguzzi, Altero; Sette, Stefania

doi:10.3390/molecules23081844

Cited by 108 publications

(79 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The need for categorization of polyphenols and for the implementation of specific and dedicated databases emerged, based on both analytical data and collected data taken from literature throughout a harmonized and standardized approach for the evaluation of an adequate dietary intake (Durazzo et al, ; Durazzo, Lucarini, et al, ).…”

Section: Phenolic Compounds and Databasesmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

Self Cite

611

397

View full text Add to dashboard Cite

This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

show abstract

Section: Phenolic Compounds and Databasesmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

Self Cite

611

397

View full text Add to dashboard Cite

show abstract

“…Nutraceutics, which derive from food matrices of vegetal or animal matrices, are a novel toolbox not yet completely explored for its full potential in medicine. Current research is looking towards several nanotechnological approaches to be exploited for the formulation of nutraceuticals [84][85][86][87][88][89][90][91][92][93], and to build up the emerging area of the nanonutraceutics [9,[94][95][96]. Nutraceutics, a portmanteau of the words 'nutrition' and 'pharmaceutical', have been recently defined as "the phytocomplex if they derive from a food of vegetal origin, and as the pool of the secondary metabolites if they derive from a food of animal origin, concentrated and administered in the more suitable pharmaceutical form" [84,97].…”

Section: From Nanopharmaceutics To Nanonutraceutics: a Bet For The Fumentioning

confidence: 99%

Nanopharmaceutics: Part II—Production Scales and Clinically Compliant Production Methods

et al. 2020

Self Cite

View full text Add to dashboard Cite

Due the implementation of nanotechnologies in the pharmaceutical industry over the last few decades, new type of cutting-edge formulations-nanopharmaceutics-have been proposed. These comprise pharmaceutical products at the nanoscale, developed from different types of materials with the purpose to, e.g., overcome solubility problems of poorly water-soluble drugs, the pharmacokinetic and pharmacodynamic profiles of known drugs but also of new biomolecules, to modify the release profile of loaded compounds, or to decrease the risk of toxicity by providing site-specific delivery reducing the systemic distribution and thus adverse side effects. To succeed with the development of a nanopharmaceutical formulation, it is first necessary to analyze the type of drug which is to be encapsulated, select the type matrix to load it (e.g., polymers, lipids, polysaccharides, proteins, metals), followed by the production procedure. Together these elements have to be compatible with the administration route. To be launched onto the market, the selected production method has to be scaled-up, and quality assurance implemented for the product to reach clinical trials, during which in vivo performance is evaluated. Regulatory issues concerning nanopharmaceutics still require expertise for harmonizing legislation and a clear understanding of clinically compliant production methods. The first part of this study addressing "Nanopharmaceutics: Part I-Clinical trials legislation and Good Manufacturing Practices (GMP) of nanotherapeutics in the EU" has been published in Pharmaceutics. This second part complements the study with the discussion about the production scales and clinically compliant production methods of nanopharmaceutics.Nanomaterials 2020, 10, 455 2 of 16 funding opportunities within Member States, Associated Countries and Third Countries. The strategic plan for the next Horizon Europe framework programme has clearly set nanomedicines and advanced therapies as priorities. To succeed, the nanoproduct needs to be manufacturable at large scale and its quality assured in order to reach clinical trials. The topic is indeed of high scientific interest considering the number of scientific papers dealing with clinical trials and nanoparticles over the last twenty years (Figure 1). Nanomaterials 2020, 10, x FOR PEER REVIEW 2 of 17European Commission aims to lead innovation towards the development of these nanopharmaceutics by launching several funding opportunities within Member States, Associated Countries and Third Countries. The strategic plan for the next Horizon Europe framework programme has clearly set nanomedicines and advanced therapies as priorities. To succeed, the nanoproduct needs to be manufacturable at large scale and its quality assured in order to reach clinical trials. The topic is indeed of high scientific interest considering the number of scientific papers dealing with clinical trials and nanoparticles over the last twenty years (Figure 1).

show abstract

“…Beverages meet consumers' demands in terms of size, shape, storage, and possibility to contain desirable nutrients and bioactive compounds [1]. Recently, Ghoshal et al [2] discussed beverages as a source of nutraceuticals [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17], clearing classification, importance, health benefits, interaction with the food, retention during storage, and delivery in the human body. Ingredients of functional beverages include vitamins, minerals, essential fatty acids, amino acids, and herbs.…”

Section: Introductionmentioning

confidence: 99%

Ready to Use Therapeutical Beverages: Focus on Functional Beverages Containing Probiotics, Prebiotics and Synbiotics

Nazhand

Souto

Lucarini³

et al. 2020

Beverages

Self Cite

View full text Add to dashboard Cite

The growing global interest in functional foods containing nutrients capable of adding possible beneficial health effects is rapidly increasing both interest and consumer demand. In particular, functionalized beverages for their potential positive effect on health e.g., decreasing cholesterol level, lowering sugar, high fiber content, ability to enhance the immune system, and help digestion, have recently received special attention. Among the different beverages available on the market, probiotic dairy and non-dairy products have attracted much attention because of their affordable cost and their numerous therapeutic activities. Fermented milk and yogurt are currently worth €46 billion, with 77% of the market reported in Europe, North America, and Asia. Consumption of dairy beverages has some limitations due for example to lactose intolerance and allergy to milk proteins, thereby leading consumers to use non-dairy beverages such as fruit, grains, and vegetable juices to add probiotics to diet as well as driving the manufacturers to food matrices-based beverages containing probiotic cultures. The purpose of this review article is to evaluate the therapeutic performance and properties of dairy and non-dairy beverages in terms of probiotic, prebiotic, and synbiotic activities.

show abstract

From Plant Compounds to Botanicals and Back: A Current Snapshot

Cited by 108 publications

References 72 publications

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Nanopharmaceutics: Part II—Production Scales and Clinically Compliant Production Methods

Ready to Use Therapeutical Beverages: Focus on Functional Beverages Containing Probiotics, Prebiotics and Synbiotics

Contact Info

Product

Resources

About