From Proteins and Protein Models to Their Use in Immunology and Immunotherapy

Sela, Michael

doi:10.1074/jbc.x300007200

Cited by 6 publications

(7 citation statements)

References 94 publications

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“…GA is a synthetic random copolymer of the four amino acids L-glutamic acid, L-lysine, L-alanine, and L-tyrosine (78)(79)(80). After clinical trials had shown benefit (81-86), GA was approved for the treatment of relapsing remitting MS.…”

Section: Ga (Copolymer 1 Copaxone)mentioning

confidence: 99%

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines

Hohlfeld

Wekerle

2004

Proc. Natl. Acad. Sci. U.S.A.

223

133

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Autoimmune T and B cell responses to CNS antigen(s) are thought to drive the pathogenesis of multiple sclerosis (MS), and thus are logical targets for therapy. Indeed, several immunomodulatory agents, including IFN-␤1b, IFN-␤1a, glatiramer acetate, and mitoxantrone, have had beneficial clinical effects in different forms of MS. However, because the available treatments are only partially effective, MS therapy needs to be further improved. Selective (antigen-specific) immunotherapies are especially appealing because in theory they combine maximal efficacy with minimal side effects. Indeed, several innovative immunotherapies have been successfully applied in experimental autoimmune encephalomyelitis. For example, autoreactive T cells can be selectively targeted by means of antigen, T cell receptor, or activation markers. However, experimental autoimmune encephalomyelitis is far from being a perfect approximation of MS because MS is more heterogeneous and the target antigen(s) is (are) not known. Further advances in MS therapy will depend on our growing understanding of the pathogenesis of this still incurable disease.

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Section: Ga (Copolymer 1 Copaxone)mentioning

confidence: 99%

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines

Hohlfeld

Wekerle

2004

Proc. Natl. Acad. Sci. U.S.A.

223

133

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“…Sela would synthesize molecules (poly amino acids) and then test their immunological properties . With time I have realized that my Ph.D. research topic, catalytic antibodies, was a natural extension of this merger of Chemistry and Immunology, albeit one that followed a wide generation gap.…”

Section: Catalytic Antibodies – Merging Chemistry and Immunologymentioning

confidence: 99%

“…When I gave my first year Ph.D. seminar (circa 1991), it was largely the emeriti professors, Sela, Pecht, Givol, Shechter, that could grasp the details and identify with my research. They were educated as chemists (including a Ph.D. and sometimes also a PostDoc in organic or physical chemistry) and acquired their knowledge of immunology ad hoc, largely via self‐education . The younger faculty, including my second mentor, Zelig Eshar, an ex‐student of Sela, were already formally educated as immunologists.…”

Section: Catalytic Antibodies – Merging Chemistry and Immunologymentioning

confidence: 99%

“…Sela would synthesize molecules (poly amino acids) and then test their immunological properties. [2] With time I have realized that my Ph.D. research topic, catalytic antibodies, was a natural extension of this merger of Chemistry and Immunology, albeit one that followed a wide generation gap. When I gave my first year Ph.D. seminar (circa 1991), it was largely the emeriti professors, Sela, Pecht, Givol, Shechter, that could grasp the details and identify with my research.…”

Section: Catalytic Antibodies -Merging Chemistry and Immunologymentioning

confidence: 99%

“…They were educated as chemists (including a Ph.D. and sometimes also a PostDoc in organic or physical chemistry) and acquired their knowledge of immunology ad hoc, largely via self-education. [2] The younger faculty, including my second mentor, Zelig Eshar, an ex-student of Sela, were already formally educated as immunologists. The students were educated mostly as biologists, or molecular biologists.…”

Section: Catalytic Antibodies -Merging Chemistry and Immunologymentioning

confidence: 99%

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A Personal Reflection on the Chemistry‐Biology Interface

Tawfik

2019

Israel Journal of Chemistry

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Chemists, including the most prominent ones, have always had a profound interest in living systems and biomolecules. Here, I describe few historical endeavors at the interface of Chemistry and Biology that inspired me and shaped my research interests. These examples highlight the uniqueness of implementing a chemist's mindset to fundamental biological questions, by obtaining biological insight via structure‐function analyses and by implementing the fundamentals of physical chemistry. I therefore see Chemical Biology as the study of biological systems and molecules with the mindset of a chemist, and in my case, of a physical organic chemist. To me, addressing biological questions with the toolset and mindset of a chemist seems so obvious and natural that there may be no need to define a specialized sub‐discipline.

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