From signalling to form: the coordination of neural tube patterning

Frith, Thomas J.R.; Briscoe, James; Boezio, Giulia L.M.

doi:10.1016/bs.ctdb.2023.11.004

Cited by 6 publications

(2 citation statements)

References 429 publications

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“…What might account for this difference in regulatory logic between flies and vertebrates? In vertebrates, patterning occurs as the neural tube grows and the spatial cues, provided by morphogen gradients, act dynamically (Frith et al, 2023). Accordingly, progenitors change their expression of spatial transcription factors as the neural tube develops.…”

Section: Discussionmentioning

confidence: 99%

“…This diversity is essential for neural circuit formation and function, yet how it arises during development remains incompletely understood. A gene regulatory network establishes spatial patterns of transcription factor expression in neural progenitors that governs the identity and pattern of neuronal and glial subtype generation (Frith et al, 2023). But spatial patterning alone fails to explain the full diversity of cell types.…”

Section: Introductionmentioning

confidence: 99%

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The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

Zhang,

Boezio,

Cornwall-Scoones

et al. 2024

Preprint

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The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organising cell fate specification has been extensively studied, temporal patterning, which controls the timing of cell type generation, is equally important. Here we define a global temporal programme in the spinal cord. This governs cell fate choices by regulating chromatin accessibility in neural progenitors. Perturbation of this cis-regulatory programme affects sequential transitions in spinal cord progenitors and the identity of progeny. The temporal programme operates in parallel to spatial patterning, ensuring the timely availability of regulatory elements for spatial determinants to direct cell-type specific gene expression. These findings identify a chronotopic spatiotemporal integration strategy in which a global temporal chromatin programme determines the output of a spatial gene regulatory network resulting in the temporally and spatially ordered allocation of cell type identity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%