From single- to multi-omics: future research trends in medicinal plants

Yang, Lifang; Yang, Ye; Huang, Luqi; Cui, Xiuming; Liu, Yuan

doi:10.1093/bib/bbac485

Cited by 27 publications

(8 citation statements)

References 119 publications

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“…Integrated multi-omics studies on MPs hold the potential to enhance and streamline the development of molecular breeding techniques and synthetic biology approaches in the field. [90]…”

Section: Biological Essence and Inspirationmentioning

confidence: 99%

Theory and scientificity of traditional Chinese medicine

Guo,

Zhang,

Huang

2023

Sci Tradit Chin Med

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The Nobel Prize for artemisinin and the COVID-19 pandemic have heightened interest in the disease prevention and treatment of traditional Chinese medicine (TCM). However, uncertainty and misinformation remain about some key issues. Herein, we discuss the current literature showing that, despite TCM gaining recognition, the theoretical systems of TCM and Western medicine rooted in different cultural backgrounds have huge differences in their theories and treatments. How to achieve accurate diagnosis in TCM, how to give scientific treatment, what is the mechanism of treatment, and what are the effect and safety of treatment, all need to be more clearly explained and require high-quality modern scientific evidence. An emerging consensus exists that, with the help of modern technology and scientific methods, it is necessary to excavate the essence of TCM that truly conforms to the laws of human life movement and disease development, realize cross-complementation with Western medicine, enhance human understanding of diseases, enrich diagnosis and treatment methods, and promote a new level in the field of life sciences.

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“…Integrated multi-omics studies on MPs hold the potential to enhance and streamline the development of molecular breeding techniques and synthetic biology approaches in the field. [90]…”

Section: Biological Essence and Inspirationmentioning

confidence: 99%

Theory and scientificity of traditional Chinese medicine

Guo,

Zhang,

Huang

2023

Sci Tradit Chin Med

Self Cite

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“…On the other hand, omics and multi-omics approaches have also allowed the investigation of defense response pathways in many crops and have been broadly used in medicinal plants, identifying candidate resistance genes and leading to an in-depth knowledge of the underlying molecular mechanisms [ 89 , 90 ]. They could be a great starting point for genome editing/genetic engineering studies, in order to obtain disease-resistant cannabis varieties [ 90 ].…”

Section: Development Of Durable Cannabis Cultivars Resistant To Pmmentioning

confidence: 99%

NLR- and mlo-Based Resistance Mechanisms against Powdery Mildew in Cannabis sativa

Sirangelo

2023

Plants

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Powdery mildew (PM) is one of the most common Cannabis sativa diseases. In spite of this, very few documented studies have characterized the resistance genes involved in PM defense mechanisms, or sources of natural genetic resistance in cannabis. The focus of the present work is on the two primary mechanisms for qualitative resistance against PM. The first is based on resistance (R) genes characterized by conserved nucleotide-binding site and/or leucine-rich repeat domains (NLRs). The second one involves susceptibility (S) genes, and particularly mildew resistance locus o (MLO) genes, whose loss-of-function mutations seem to be a reliable way to protect plants from PM infection. Cannabis defenses against PM are thus discussed, mainly detailing the strategies based on these two mechanisms. Emerging studies about this research topic are also reported and, based on the most significant results, a potential PM resistance model in cannabis plant–pathogen interactions is proposed. Finally, innovative approaches, based on the pyramiding of multiple R genes, as well as on genetic engineering and genome editing methods knocking out S genes, are discussed, to obtain durable PM-resistant cannabis cultivars with a broad-spectrum resistance range.

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“…Instead, phenotypic plasticity is shaped by many molecular mechanisms, including epigenetic modification, gene expression and silencing, post-translational protein modification, and metabolite accumulation. Therefore, a single omics cannot sufficiently and comprehensively unravel the complex biological regulatory networks controlling the various phenotypic traits [171].…”

Section: Multi-omics Integrationmentioning

confidence: 99%

Multi-Omics Techniques for Forest Plant Breeding

Wang¹,

Li²,

Zhao³

2023

Preprint

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In recent years, the ecological and economic values of forest plants have been gradually recognized worldwide. However, the growing global demand for new forest plant varieties with higher wood production capacity and better stress tolerance cannot be satisfied by conventional phenotype-based breeding, marker-assisted selection, and genomic selection. In the recent past, diverse omics technologies, including genomics, transcriptomics, epigenomics, proteomics, and metabolomics, have been developed rapidly, providing powerful tools for the precision genetic breeding of forest plants. Genomics lays a solid foundation for understanding complex biological regulatory networks, while other omics technologies provide different perspectives at different levels. Multi-omics integration has combined the different omics technologies, becoming a powerful tool for genome-wide functional element identification in forest plant breeding. This review summarizes the recent progress of omics technologies and their applications in the genetic studies of forest plants. It will provide forest plant breeders with an elementary knowledge of multi-omics techniques for future breeding programs.

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From single- to multi-omics: future research trends in medicinal plants

Cited by 27 publications

References 119 publications

Theory and scientificity of traditional Chinese medicine

Theory and scientificity of traditional Chinese medicine

NLR- and mlo-Based Resistance Mechanisms against Powdery Mildew in Cannabis sativa

Multi-Omics Techniques for Forest Plant Breeding

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