From the Womb into the World: Protecting the Fetal Brain from Maternal Stress During Pregnancy

Heuvel, Marion I. van den

doi:10.1177/23727322211068024

Cited by 10 publications

(4 citation statements)

References 87 publications

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“…Anak-anakku menjerit dari masa lalu Sementara bapak dan emakku Sudah lama tidur Rahim or a womb is the vital reproduction for a woman and is the firm organ of a woman. Heuvel (2022) explains that a womb is important for fetal growth and the first medium to bring the fetus in to the world. The author describes the womb in a broader meaning related to women.…”

Section: Melumat Rahimkumentioning

confidence: 99%

The Social Criticisms of Rah(i)m Poetry by Kedung Darma Romansha

Alfadlilah

2023

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An expressing media with literature work could indirectly convey various social criticisms toward a certain phenomenon. The most frequently occurring social criticism is the social reality portrayal of a community. This study aims to describe the form of social criticism contained in the poetry entitled Rahi(i)m by Kedung Darma Romansha. Using qualitative methods and a literary sociology approach, especially social criticism, this study reveals the author's worldview of phenomena that occur in society. The study results show that the author of poetry criticises social situations, namely: the author's criticism of poverty, crime, family disharmony, juvenile delinquency, violation of norms, and environmental problems. Social criticism also reveals the author's disappointment, annoyance, anger, and regret towards the arrogant and unfair performance of government officials in responding to socio-cultural problems that occur in society.

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Section: Melumat Rahimkumentioning

confidence: 99%

The Social Criticisms of Rah(i)m Poetry by Kedung Darma Romansha

Alfadlilah

2023

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“…Zo zijn bijvoorbeeld nega tieve geboorte-uitkomsten in het vroege leven ge associeerd met gezondheidsproblemen op latere leeftijd (9). Ook de geestelijke gezondheid van de moeder tijdens de eerste 1.000 dagen is belangrijk voor de ontwikkeling van het kind (10)(11)(12). Zo is aangetoond dat de neurobiologische ontwikkeling afhankelijk is van de perinatale gemoedstoestand van de moeder, met mogelijke gevolgen voor de nakomeling later in het leven.…”

Section: "De Eerste 1000 Dagen Van Het Leven Vormen Een Periode Van Z...unclassified

Maternale veerkracht en sociale ongelijkheid tijdens de perinatale periode: invloed van onderliggende biologische mechanismen

Vos¹,

Bergh²,

Roels³

et al. 2023

Tijdschr Geneesk

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Maternal resilience and social inequality during the perinatal period: influence of underlying biological mechanisms and potential intervention strategies The first 1,000 days (from conception until the second year of life) represent a crucial stage of life. It is a sensitive period for the development and health of the child, as well as for the wellbeing of the mother. This timespan includes the perinatal period, namely the period from conception up until 1 year after birth. Scientific evidence demonstrates that socio-economic factors, such as social inequality, are related to health outcomes during the perinatal period. Psychosocial stressors as a consequence of the socio-economic background represent a potential source of inequalities in health. These associations between mental health during pregnancy, social inequalities and health outcomes can be explained by various underlying biological mechanisms. At the same time, improving psychological resilience during the first 1,000 days can have beneficial effects on these associations. By focusing on interventions aimed at improving mental resilience, the wellbeing and health of both parents and their offspring later in life can be improved.

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“…Worldwide the societal burden of mental health problems is increasing (Vigo et al, 2016 ). Although early stage prevention is more cost-efficient than treatment (Bauer et al, 2016 ), prenatal origins of mental health problems that are often preventable remain understudied (Browne et al, 2020 ; Glover, 2011 ; Monk et al, 2019 ; van den Heuvel, 2022 ). In a UK-based study, it has been estimated that perinatal anxiety and depression combined costs the society about £8500 per woman giving birth.…”

Section: Introductionmentioning

confidence: 99%

Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring

Turk

Heuvel

Sleurs

et al. 2023

Brain Imaging and Behavior

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Background The connectome, constituting a unique fingerprint of a person’s brain, may be influenced by its prenatal environment, potentially affecting later-life resilience and mental health. Methods We conducted a prospective resting-state functional Magnetic Resonance Imaging study in 28-year-old offspring (N = 49) of mothers whose anxiety was monitored during pregnancy. Two offspring anxiety subgroups were defined: “High anxiety” (n = 13) group versus “low-to-medium anxiety” (n = 36) group, based on maternal self-reported state anxiety at 12–22 weeks of gestation. To predict resting-state functional connectivity of 32 by 32 ROIs, maternal state anxiety during pregnancy was included as a predictor in general linear models for both ROI-to-ROI and graph theoretical metrics. Sex, birth weight and postnatal anxiety were included as covariates. Results Higher maternal anxiety was associated with weaker functional connectivity of medial prefrontal cortex with left inferior frontal gyrus (t = 3.45, pFDR < 0.05). Moreover, network-based statistics (NBS) confirmed our finding and revealed an additional association of weaker connectivity between left lateral prefontal cortex with left somatosensory motor gyrus in the offspring. While our results showed a general pattern of lower functional connectivity in adults prenatally exposed to maternal anxiety, we did not observe significant differences in global brain networks between groups. Conclusions Weaker (medial) prefrontal cortex functional connectivity in the high anxiety adult offspring group suggests a long-term negative impact of prenatal exposure to high maternal anxiety, extending into adulthood. To prevent mental health problems at population level, universal primary prevention strategies should aim at lowering maternal anxiety during pregnancy.

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From the Womb into the World: Protecting the Fetal Brain from Maternal Stress During Pregnancy

Cited by 10 publications

References 87 publications

The Social Criticisms of Rah(i)m Poetry by Kedung Darma Romansha

The Social Criticisms of Rah(i)m Poetry by Kedung Darma Romansha

Maternale veerkracht en sociale ongelijkheid tijdens de perinatale periode: invloed van onderliggende biologische mechanismen

Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring

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