From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis

Castelli, Lydia; Vasta, Rosario; Allen, Scott P.; Waller, Rachel; Chiò, Adriano; Traynor, Bryan J.; Kirby, Janine

doi:10.1016/bs.irn.2024.02.001

International Review of Neurobiology

2024

DOI: 10.1016/bs.irn.2024.02.001

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From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis

Lydia Castelli,

Rosario Vasta,

Scott P. Allen

et al.

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2024

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Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Kim,

Hwang,

George

et al. 2024

IJMS

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Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Recent studies have highlighted the significant role of cerebrospinal fluid (CSF) in reflecting pathophysiological PD brain conditions by analyzing the components of CSF. Based on the published literature, we created a single network with altered metabolites in the CSF of patients with PD. We analyzed biological functions related to the transmembrane of mitochondria, respiration of mitochondria, neurodegeneration, and PD using a bioinformatics tool. As the proteome reflects phenotypes, we collected proteome data based on published papers, and the biological function of the single network showed similarities with that of the metabolomic network. Then, we analyzed the single network of integrated metabolome and proteome. In silico predictions based on the single network with integrated metabolomics and proteomics showed that neurodegeneration and PD were predicted to be activated. In contrast, mitochondrial transmembrane activity and respiration were predicted to be suppressed in the CSF of patients with PD. This review underscores the importance of integrated omics analyses in deciphering PD’s complex biochemical networks underlying neurodegeneration.

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Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Kim,

Hwang,

George

et al. 2024

IJMS

View full text Add to dashboard Cite

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From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis

Cited by 1 publication

References 243 publications

Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

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