From wild harvest towards precision agriculture: Use of Ecological Niche Modelling to direct potential cultivation of wild medicinal plants in Crete

Bariotakis, Michael; Georgescu, Luciana; Laina, Danae; Oikonomou, Ioanna; Ntagounakis, George; Koufaki, Margarita-Ioanna; Souma, Maria; Choreftakis, Michalis; Zormpa, Ourania Grigoriadou; Smýkal, Petr; Sourvinos, George; Lionis, Christos; Castanas, Elias; Karousou, Regina; Pirintsos, Stergios

doi:10.1016/j.scitotenv.2019.133681

Cited by 19 publications

(11 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, a new tool based on Ecological Niche Modeling has been developed, in order to support local farmers in the decisionmaking process, concerning the suitability of the area where their land is located, for cultivation of medicinal taxa of high ethnopharmacological interest (Bariotakis et al, 2019). A webbased, easy-to-use application was created in the framework of precision agriculture, where the predicted suitability scores for each area of interest can be made accessible to anyone, by the use of its GPS coordinates.…”

Section: A Case Study Of the Use Of Plant Extracts As A Pharmaceuticamentioning

confidence: 99%

The Therapeutic Potential of the Essential Oil of Thymbra capitata (L.) Cav., Origanum dictamnus L. and Salvia fruticosa Mill. And a Case of Plant-Based Pharmaceutical Development

et al. 2020

View full text Add to dashboard Cite

This review performs a comprehensive assessment of the therapeutic potential of three native herbs of Crete (Thymbra capitata (L.) Cav., Salvia fruticosa Mill. and Origanum dictamnus L.), their phytochemical constituents, health benefits and issues relevant to their safety, within a translational context. Issues discussed comprise: 1) Ethnopharmacological uses of the three herbs, reviewed through an extensive search of the literature; 2) Systematic analysis of the major phytochemical constituents of each plant, and their medicinal properties; 3) To what extent could the existing medicinal properties be combined and produce an additive or synergistic effect; 4) Possible safety issues. We conclude with a specific example of the use of a combination of the essential oils of these plants as an effective anti-viral product and the experience gained in a case of a plant-based pharmaceutical development, by presenting the major steps and the continuum of the translational chain.

show abstract

Section: A Case Study Of the Use Of Plant Extracts As A Pharmaceuticamentioning

confidence: 99%

The Therapeutic Potential of the Essential Oil of Thymbra capitata (L.) Cav., Origanum dictamnus L. and Salvia fruticosa Mill. And a Case of Plant-Based Pharmaceutical Development

et al. 2020

View full text Add to dashboard Cite

show abstract

“…F. synonym of Thymbra capitata (L) Cav. ), dictamnus or Cretan dittany ( Origanum dictamnus L) and sage ( Salvia fruticosa Mill., Salvia pomifera L., were cultivated under total Good Agricultural Practice and high precision agriculture, based on an Ecological Niche Modelling tool, we have recently developed (Bariotakis et al, 2019), in order to maximize their essential oil composition and content. A constant genotype of plants, specified by a barcoding of each batch, was used.…”

Section: Methodsmentioning

confidence: 99%

A mixture of essential oils from three Cretan Aromatic Plants (thyme, Greek sage and Cretan dittany, CAPeo) inhibits SASR-CoV-2 proliferation:in vitroevidence and a Proof-of-Concept intervention study in mild ambulatory COVID-19-positive patients

Lionis

Karakasiliotis

Petelos

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

The need for therapeutic regimens for the non-critically ill patients of the COVID-19 pandemic remains unmet. In this line, repurposing existing drugs, against known or predicted SARS-CoV-2 protein actions, has been advanced, while natural products have also been tested. Previous work has shown that a Cretan Aromatic Plant (Thymbra capitata (L.) Cav., Salvia fruticosa Mill. and Origanum dictamnus L.) essential oil mixture (CAPeo) has a remarkable in vitro antiviral activity against Influenza A & B and Rhinovirus 14 strains, decreasing the symptoms of upper respiratory tract infections, while proven safe in experimental animals and humans. Here, we tested CAPeo in VERO cells infected with SASR-CoV-2. We report that this mixture, at similar concentrations as those previously reported, exhibits a remarkable antiviral activity. Administration of 1 ml of a 1.5% CAPeo in olive oil, in a Proof-of-Concept intervention study in SARS-CoV-2-positive, exhibiting mild COVID-19 symptoms, humans resulted in a significant amelioration of general and local symptoms of the disease. We conclude that CAPeo may be a valuable addition for the prevention and/or treatment of mild COVID-19 ambulatory patients, pending a confirmation through a prospective randomized controlled trial in humans (NCT04705753).

show abstract

“…This classification was proposed as a guide for the decision-making process for both healthcare providers and consumers. Moreover, taking into consideration that several data matrices have been published in many world areas, ranging from regional to continental scale, we attempted to demonstrate, for the first time, the implementation of partial-order techniques, processing ethnopharmacological information, with the purpose to reveal hidden inner structures and characteristics of reported raw data [41]. This methodology could potentially contribute to the conceptualization and management of ethnopharmacological knowledge [18].…”

Section: Evolution Of Natural-product-derived Drug Development 21 Tra...mentioning

confidence: 99%

From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples

et al. 2022

Self Cite

View full text Add to dashboard Cite

Ethnopharmacology, through the description of the beneficial effects of plants, has provided an early framework for the therapeutic use of natural compounds. Natural products, either in their native form or after crude extraction of their active ingredients, have long been used by different populations and explored as invaluable sources for drug design. The transition from traditional ethnopharmacology to drug discovery has followed a straightforward path, assisted by the evolution of isolation and characterization methods, the increase in computational power, and the development of specific chemoinformatic methods. The deriving extensive exploitation of the natural product chemical space has led to the discovery of novel compounds with pharmaceutical properties, although this was not followed by an analogous increase in novel drugs. In this work, we discuss the evolution of ideas and methods, from traditional ethnopharmacology to in silico drug discovery, applied to natural products. We point out that, in the past, the starting point was the plant itself, identified by sustained ethnopharmacological research, with the active compound deriving after extensive analysis and testing. In contrast, in recent years, the active substance has been pinpointed by computational methods (in silico docking and molecular dynamics, network pharmacology), followed by the identification of the plant(s) containing the active ingredient, identified by existing or putative ethnopharmacological information. We further stress the potential pitfalls of recent in silico methods and discuss the absolute need for in vitro and in vivo validation as an absolute requirement. Finally, we present our contribution to natural products’ drug discovery by discussing specific examples, applying the whole continuum of this rapidly evolving field. In detail, we report the isolation of novel antiviral compounds, based on natural products active against influenza and SARS-CoV-2 and novel substances active on a specific GPCR, OXER1.

show abstract

From wild harvest towards precision agriculture: Use of Ecological Niche Modelling to direct potential cultivation of wild medicinal plants in Crete

Cited by 19 publications

References 64 publications

The Therapeutic Potential of the Essential Oil of Thymbra capitata (L.) Cav., Origanum dictamnus L. and Salvia fruticosa Mill. And a Case of Plant-Based Pharmaceutical Development

The Therapeutic Potential of the Essential Oil of Thymbra capitata (L.) Cav., Origanum dictamnus L. and Salvia fruticosa Mill. And a Case of Plant-Based Pharmaceutical Development

A mixture of essential oils from three Cretan Aromatic Plants (thyme, Greek sage and Cretan dittany, CAPeo) inhibits SASR-CoV-2 proliferation:in vitroevidence and a Proof-of-Concept intervention study in mild ambulatory COVID-19-positive patients

From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples

Contact Info

Product

Resources

About