Frondoside A potentiates the effects of conventional therapeutic agents in acute leukemia

Marine natural products

“…705 Two examples, henricioside H and levisculoside G, were conrmed as modest inhibitors in a puried enzyme assay. In other biological testing, frondoside A exhibits synergistic effects against acute leukaemia cell lines in the presence of conventional anticancer drugs, 706 semi-puried triterpene glycoside extracts exhibit antifouling activity in coated-plate sea trials, 707 intraperitoneal administration of cucmarioside A 2 -2 leads to an increase in markers associated with spleen macrophage activation, 708 luzonicoside A was found to be more potent than luzonicoside D at inhibiting proliferation of human melanoma cells in vitro by cell cycle regulation and induction of apoptosis, 709 anthraquinones from Comanthus sp. exhibited cytotoxicity and were strong kinase inhibitors, 710 and (Z)-2,3diphenylacrylonitrile (Holothuria parva) caused an increase in ROS generation and collapse of the mitochondrial membrane potential in hepatocellular carcinoma cells.…”

The Anti-Cancer Effects of Frondoside A

“…The effects of frondoside A on cell viability or proliferation has been tested using multiple different methods in many different cancers. This has included studies on pancreatic ductal adenocarcinoma, breast, non-small cell lung, colon, prostate, cervix, bladder (transitional cell), Burkitt lymphoma, malignant germ cell, and acute leukemias [ 11 , 12 , 13 , 14 , 16 , 18 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 ]. Methods employed have included cell counts, thymidine incorporation, MTT assay, and CellTiterGlo (Promega, Madison, WI, USA) assays.…”

“…One particular triterpenoid glycoside, frondoside A has received particular attention, since it has shown potent anti-cancer effects in a broad spectrum of solid malignancies as well as in leukemias. Here, we will review the nature of frondoside A, its effects on cancer cell growth, cell cycle, apoptosis, angiogenesis, migration, invasion, and formation of metastases [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. We will also review the pharmacokinetics, toxicity, interactions with other anti-cancer therapeutics, effects on the immune system, and possible mechanisms of action of this compound [ 13 , 16 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

The Marine-Derived Triterpenoid Frondoside A Inhibits Thrombus Formation

“…The PI3K pathway has been shown to be a dominant signaling pathway in different nucleate cell types, which regulates the balance between apoptosis and survival [34]. Several groups have reported that frondoside A exerts potent anti-cancer effects in vitro and in vivo [19,35]. It is conceivable that this compound also affects the viability of non-malignant cells, such as platelets.…”

“…Moreover, this compound is capable of potentiating the anticancer effects of conventional cytotoxic drugs such as gemcitabine and 5-fluorouracil [13,16]. Detailed molecular analyses revealed that these effects are mainly mediated by the inhibition of PI3K, resulting in reduced Akt signaling and caspase-induced cell death [17][18][19]. Platelet-rich plasma (PRP) was incubated with different concentrations of frondoside A (black bars, n = 5) or vehicle (white bar, n = 5) for 30 min.…”